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Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in diabetes

Objective

An absolute or relative loss of beta-cell mass and function underlie the development of type I and type 2 diabetes.Preventing beta-cell demise or restoring their number and function is a major therapeutic goal. However,development of novel diagnostic and prognostic tools, and of novel therapeutic modalities, is hampered by the limited knowledge of the molecular pathways that control beta-cell demise in diabetes, the production of new beta-cells from progenitors,or the replication and preserved function of mature beta-cells. Here,we propose an integrated approach to generate and exploit new
cellular and animal models, and to develop novel investigative tools and biomarkers to gain new knowledge on the mechanisms of beta-cell function and demise in diabetes, to improve diabetes diagnostic and to identify novel therapeutic targets for drug development. To achieve this ambitious goal,we have established a consortium of leading European experts from universities and SMEs in the fields of beta-cell diabetes research,
gene transfer technology, metabolom ics, biomedical imaging, bioinformatics and systems
modeling. We propose a work plan composed of 5 scientific work packages structured to provide high levels of interaction within the network and with EFPIA partners.
A management and administration work package will permit an efficient cooperation between
universities, SMEs and industrial partners to ensure that the particular interests and
needs of pharmaceutical industry research are addressed.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/medical biotechnology/genetic engineering/gene therapy

Call for proposal

IMI-JU-01-2008
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

SANOFI-AVENTIS DEUTSCHLAND GMBH
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Werner Kramer (Prof. Dr. Dr.)
Administrative Contact
Peter Hecht (Dr.)

Participants (20)

UNIVERSITE DE LAUSANNE
Switzerland
EU contribution
€ 1 274 479
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexandra Defago (Ms.)
INSTITUT DE RECHERCHES SERVIER
France
Address
3 Rue De La Republique
92150 Suresnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
ALAIN KTORZA (Professor)
ASTRAZENECA AB
Sweden
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Lindgren (-)
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Address
Binger Strasse
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rolf Göggel (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 470 356
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Louis Avigdor (Mr)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 412 000
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Sandrine PIETRI (Mrs)
SARL ENDOCELLS
France
EU contribution
€ 466 000
Address
Boulevard Saint Germain
75007 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anne-Fabienne Weitsch (Dr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 079 744
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Mrs)
SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 450 961
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
Administrative Contact
Jocelyne Bocquet (N/A)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 504 340
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Nicolas Jeanjean (Mr)
Eli Lilly and Company Limited
United Kingdom
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Steckel-Hamann (Dr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 490 300
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Steinhusen (Mrs)
NOVARTIS PHARMA AG
Switzerland
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barbara Stolz (Dr)
NOVO NORDISK A/S
Denmark
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Allan Ertmann Karlsen (Prof.)
F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Everson Nogoceke (Dr)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 666 800
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katja Pfriem (Mrs)
UNIVERSITA DI PISA
Italy
EU contribution
€ 491 040
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea degl'Innocenti (Mrs)
UNIVERSITE PARIS DIDEROT - PARIS 7
France
EU contribution
€ 623 600
Address
Rue Thomas Mann 5
75205 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maurice Muriel (Mr)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 834 340
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alex Waehry (Dr)
VRIJE UNIVERSITEIT BRUSSEL
Belgium
EU contribution
€ 296 800
Address
Pleinlaan 2
1050 Brussel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nik Claesen (Mr)