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Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in diabetes


An absolute or relative loss of beta-cell mass and function underlie the development of type I and type 2 diabetes.Preventing beta-cell demise or restoring their number and function is a major therapeutic goal. However,development of novel diagnostic and prognostic tools, and of novel therapeutic modalities, is hampered by the limited knowledge of the molecular pathways that control beta-cell demise in diabetes, the production of new beta-cells from progenitors,or the replication and preserved function of mature beta-cells. Here,we propose an integrated approach to generate and exploit new
cellular and animal models, and to develop novel investigative tools and biomarkers to gain new knowledge on the mechanisms of beta-cell function and demise in diabetes, to improve diabetes diagnostic and to identify novel therapeutic targets for drug development. To achieve this ambitious goal,we have established a consortium of leading European experts from universities and SMEs in the fields of beta-cell diabetes research,
gene transfer technology, metabolom ics, biomedical imaging, bioinformatics and systems
modeling. We propose a work plan composed of 5 scientific work packages structured to provide high levels of interaction within the network and with EFPIA partners.
A management and administration work package will permit an efficient cooperation between
universities, SMEs and industrial partners to ensure that the particular interests and
needs of pharmaceutical industry research are addressed.

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EU contribution
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65929 Frankfurt Am Main

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Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Werner Kramer (Prof. Dr. Dr.)
Administrative Contact
Peter Hecht (Dr.)
Total cost
No data

Participants (20)