Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in diabetes

Project Information

IMIDIA

Grant agreement ID: 115005

Project closed

Start date 1 February 2010

End date 30 September 2015

Funded under

• Specific Programme "Cooperation": Joint Technology Initiatives

Total cost € 27 447 009,00

EU contribution € 8 060 760,00

Coordinated by

SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany

Objective

An absolute or relative loss of beta-cell mass and function underlie the development of type I and type 2 diabetes.Preventing beta-cell demise or restoring their number and function is a major therapeutic goal. However,development of novel diagnostic and prognostic tools, and of novel therapeutic modalities, is hampered by the limited knowledge of the molecular pathways that control beta-cell demise in diabetes, the production of new beta-cells from progenitors,or the replication and preserved function of mature beta-cells. Here,we propose an integrated approach to generate and exploit new
cellular and animal models, and to develop novel investigative tools and biomarkers to gain new knowledge on the mechanisms of beta-cell function and demise in diabetes, to improve diabetes diagnostic and to identify novel therapeutic targets for drug development. To achieve this ambitious goal,we have established a consortium of leading European experts from universities and SMEs in the fields of beta-cell diabetes research,
gene transfer technology, metabolom ics, biomedical imaging, bioinformatics and systems
modeling. We propose a work plan composed of 5 scientific work packages structured to provide high levels of interaction within the network and with EFPIA partners.
A management and administration work package will permit an efficient cooperation between
universities, SMEs and industrial partners to ensure that the particular interests and
needs of pharmaceutical industry research are addressed.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• medical and health sciences › clinical medicine › endocrinology › diabetes

Programme(s)

• FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives

Topic(s)

• IMI-JU-01-2008-07 - Islet Cell Research

Call for proposal

IMI-JU-01-2008
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

SANOFI-AVENTIS DEUTSCHLAND GMBH

Principal investigator

Werner Kramer (Prof. Dr. Dr.)

Administrative Contact

Peter Hecht (Dr.)

• EU contribution: No data
• Address: BRUNINGSTRASSE 50 ; 65929 Frankfurt Am Main ; Germany
• Region: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

Participants (20)

UNIVERSITE DE LAUSANNE

Switzerland

Administrative Contact

Alexandra Defago (Ms.)

• EU contribution: € 1 274 479,00
• Address: QUARTIER UNIL CENTRE - BATIMENT UNICENTRE ; 1015 LAUSANNE
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Vaud
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

INSTITUT DE RECHERCHES SERVIER

France

Administrative Contact

ALAIN KTORZA (Professor)

• EU contribution: No data
• Address: 22 ROUTE 128 ; 91190 GIF-SUR-YVETTE
• Region: Ile-de-France › Ile-de-France › Essonne
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

ASTRAZENECA AB

Sweden

Administrative Contact

Eva Lindgren (-)

• EU contribution: No data
• Address: Vastra Maelarhamnen ; 151 85 Sodertaelje
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

BOEHRINGER INGELHEIM INTERNATIONALGMBH

Germany

Administrative Contact

Rolf Göggel (Dr.)

• EU contribution: No data
• Address: BINGER STRASSE ; 55218 Ingelheim
• Region: Rheinland-Pfalz › Rheinhessen-Pfalz › Mainz-Bingen
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

Administrative Contact

Louis Avigdor (Mr)

• EU contribution: € 470 356,00
• Address: RUE MICHEL ANGE 3 ; 75794 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Total cost: No data

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

Administrative Contact

Sandrine PIETRI (Mrs)

• EU contribution: € 412 000,00
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Total cost: No data

SARL ENDOCELLS

France

Administrative Contact

Anne-Fabienne Weitsch (Dr.)

• EU contribution: € 466 000,00
• Address: Boulevard Saint Germain 216 ; 75007 Paris
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

Administrative Contact

Tatjana Palalic (Mrs)

• EU contribution: € 1 079 744,00
• Address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Region: London › Inner London — West › Westminster
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

SIB SWISS INSTITUTE OF BIOINFORMATICS

Switzerland

Administrative Contact

Jocelyne Bocquet (N/A)

• EU contribution: € 450 961,00
• Address: RUE MICHEL SERVET 1 CMU ; 1206 Geneve
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Genève
• Activity type: Research Organisations
• Total cost: No data

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Administrative Contact

Nicolas Jeanjean (Mr)

• EU contribution: € 504 340,00
• Address: RUE DE TOLBIAC 101 ; 75654 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Total cost: No data

ELI LILLY AND COMPANY LTD

United Kingdom

Administrative Contact

Birgit Steckel-Hamann (Dr.)

• EU contribution: No data
• Address: LILLY HOUSE BASINGVIEW ; RG21 4FA Basingstoke
• Region: South East (England) › Hampshire and Isle of Wight › North Hampshire
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

Administrative Contact

Angela Steinhusen (Mrs)

• EU contribution: € 490 300,00
• Address: Carl-Neuberg-Strasse 1 ; 30625 Hannover
• Region: Niedersachsen › Hannover › Region Hannover
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

NOVARTIS PHARMA AG

Switzerland

Administrative Contact

Barbara Stolz (Dr)

• EU contribution: No data
• Address: LICHTSTRASSE 35 ; 4056 Basel
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

NOVO NORDISK A/S

Denmark

Administrative Contact

Allan Ertmann Karlsen (Prof.)

• EU contribution: No data
• Address: NOVO ALLE 1 ; 2880 Bagsvaerd
• Region: Danmark › Hovedstaden › Københavns omegn
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

F. HOFFMANN-LA ROCHE AG

Switzerland

Administrative Contact

Everson Nogoceke (Dr)

• EU contribution: No data
• Address: GRENZACHERSTRASSE 124 ; 4070 Basel
• Region: Schweiz/Suisse/Svizzera › Nordwestschweiz › Basel-Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Total cost: No data

TECHNISCHE UNIVERSITAET DRESDEN

Germany

Administrative Contact

Katja Pfriem (Mrs)

• EU contribution: € 666 800,00
• Address: HELMHOLTZSTRASSE 10 ; 01069 Dresden
• Region: Sachsen › Dresden › Dresden, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

UNIVERSITA DI PISA

Italy

Administrative Contact

Andrea degl'Innocenti (Mrs)

• EU contribution: € 491 040,00
• Address: LUNGARNO PACINOTTI 43/44 ; 56126 Pisa
• Region: Centro (IT) › Toscana › Pisa
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

Université Paris Diderot-Paris 7

France

Administrative Contact

Maurice Muriel (Mr)

• EU contribution: € 623 600,00
• Address: Rue Thomas Mann ; F-75205 / 13 Paris
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

UNIVERSITE DE GENEVE

Switzerland

Administrative Contact

Alex Waehry (Dr)

• EU contribution: € 834 340,00
• Address: RUE DU GENERAL DUFOUR 24 ; 1211 Geneve
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Genève
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data

VRIJE UNIVERSITEIT BRUSSEL

Belgium

Administrative Contact

Nik Claesen (Mr)

• EU contribution: € 296 800,00
• Address: PLEINLAAN 2 ; 1050 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Higher or Secondary Education Establishments
• Total cost: No data