Obiettivo
An absolute or relative loss of beta-cell mass and function underlie the development of type I and type 2 diabetes.Preventing beta-cell demise or restoring their number and function is a major therapeutic goal. However,development of novel diagnostic and prognostic tools, and of novel therapeutic modalities, is hampered by the limited knowledge of the molecular pathways that control beta-cell demise in diabetes, the production of new beta-cells from progenitors,or the replication and preserved function of mature beta-cells. Here,we propose an integrated approach to generate and exploit new
cellular and animal models, and to develop novel investigative tools and biomarkers to gain new knowledge on the mechanisms of beta-cell function and demise in diabetes, to improve diabetes diagnostic and to identify novel therapeutic targets for drug development. To achieve this ambitious goal,we have established a consortium of leading European experts from universities and SMEs in the fields of beta-cell diabetes research,
gene transfer technology, metabolom ics, biomedical imaging, bioinformatics and systems
modeling. We propose a work plan composed of 5 scientific work packages structured to provide high levels of interaction within the network and with EFPIA partners.
A management and administration work package will permit an efficient cooperation between
universities, SMEs and industrial partners to ensure that the particular interests and
needs of pharmaceutical industry research are addressed.
Campo scientifico
Argomento(i)
Invito a presentare proposte
IMI-JU-01-2008
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Meccanismo di finanziamento
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)Coordinatore
65929 Frankfurt Am Main
Germania
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Partecipanti (20)
1015 LAUSANNE
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91190 GIF-SUR-YVETTE
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151 85 Sodertaelje
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55218 Ingelheim
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75794 Paris
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75015 PARIS 15
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75007 Paris
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SW7 2AZ LONDON
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1206 Geneve
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75654 Paris
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RG21 4FA Basingstoke
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30625 Hannover
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4056 Basel
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2880 Bagsvaerd
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4070 Basel
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01069 Dresden
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56126 Pisa
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F-75205 / 13 Paris
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1211 Geneve
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1050 Bruxelles / Brussel
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