Objective
PHARMA-COG aims to develop a new integrated model to accelerate the development of drug cindidates for MS, PKD and AD. The innovation relies on a 'multidimensional matrix' approach, integrating all available and renewed inputs (biomarkers/animal, human models/physiological and pharmcological challenges, Phase 0/1/1b to reduce the attrition rate, to allow an early and pertinent GO/NOGO decision before entering phase II trials for both symptomatic treatment and disease modifiers approaches. The hypothesis is that effective long term drugs will normalize markers artificially modified. The general objective is to test the efficiency of the 'matrix' on drug candidates for the enhancement/protection of cognitive functions. the final objective is to improve the detection and selection of new drugs candidates within a shorter teim-frame.
Our consortium gathers 13 academics and clinicians, 8 SMEs, 1 European patient organization (Alzheimer Europe) as well as 1 regulatory body (EMEA), coming form six different EU Members States. Excellence Centres gather representatives of the different sectors: biomarkers (proteomics, transcriptomics), pharmacodynamic markers ( electrophysiology, psychophysiology, morphological and functional imaging), preclinical model specialists (cellular, transgenic mouse, monkey), clinicians, and clinical pharmacologists.
By the end of this (-year project, the following achievements are expected; definition of the most predictive combination of pharmacodynamic markers; validation of parallel models (in healthy volunteers, ApoE 4 subjects,patients and animals) to establish effective exposure ranges and support proof of mechanism studies. The predictive value of the 'matrix' will be evaluated using different pharmacological target acting drugs. Suugestions for revised/new recomendations and guidellines will help to standardize the pre-clinical and clinical phases of drugs' development in neurodegenerative diseases.
Fields of science
Call for proposal
IMI-JU-01-2008
See other projects for this call
Coordinator
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
EU contribution
No data
Address
Great West Road 980
TW89GS Brentford
United Kingdom
TW89GS Brentford
United Kingdom
See on map
Region
London
Outer London — West and North West
Hounslow and Richmond upon Thames
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Graham Ian Somers (Dr.)
Principal investigator
Jill C Richardson (Dr.)
Links
Total cost
No data
Participants (37)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 1 658 892,00
Address
BOULEVARD CHARLES LIVON 58 LE PHARO
13284 Marseille
13284 Marseille
See on map
Region
Provence-Alpes-Côte d’Azur
Provence-Alpes-Côte d’Azur
Bouches-du-Rhône
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Ms.)
Links
Total cost
No data
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 560 973,00
Address
CALLE ROSSELLO 149 PUERTA BJS
08036 Barcelona
08036 Barcelona
See on map
Region
Este
Cataluña
Barcelona
Activity type
Other
Administrative Contact
Pastora Martinez Samper (Mrs)
Links
Total cost
No data
Université Lille 2 Droit et Santé
France
EU contribution
€ 1 066 828,00
Address
Rue Paul Duez
59000 LILLE
59000 LILLE
See on map
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie GOMPEL (Dr.)
Links
Total cost
No data
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 176 715,00
Address
RITTERSTRASSE 26
04109 Leipzig
04109 Leipzig
See on map
Region
Sachsen
Leipzig
Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tilman Hensch (Dr.)
Links
Total cost
No data
UNIVERSIDAD DE MURCIA
Spain
EU contribution
€ 300 000,00
Address
AVENIDA TENIENTE FLOMESTA S/N - EDIFICIO CONVALECENCIA
30003 Murcia
30003 Murcia
See on map
Region
Sur
Región de Murcia
Murcia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Sanchez-Merenciano (Manager)
Links
Total cost
No data
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 70 748,00
Address
HUFELANDSTRASSE 55
45147 Essen
45147 Essen
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Region
Nordrhein-Westfalen
Düsseldorf
Essen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Willibald Kroening (Mr.)
Links
Total cost
No data
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 205 000,00
Address
RUE MICHEL ANGE 3
75794 Paris
75794 Paris
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Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Administrative Contact
Julie Zitel (Mrs)
Links
Total cost
No data
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 010 591,00
Address
RUE DE TOLBIAC 101
75654 Paris
75654 Paris
See on map
Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Administrative Contact
Armelle Barelli (Mrs)
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 360 000,00
Address
VIA DELL ARTIGLIERE 8
37129 Verona
37129 Verona
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Region
Nord-Est
Veneto
Verona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Manuela Calderara (Ms)
Links
Total cost
No data
PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI
Italy
EU contribution
€ 767 507,00
Address
VIA PILASTRONI 4
25125 Brescia
25125 Brescia
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Region
Nord-Ovest
Lombardia
Brescia
Activity type
Research Organisations
Administrative Contact
Fra Marco Fabello (-)
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI FOGGIA
Italy
EU contribution
€ 448 496,00
Address
VIA GRAMSCI 89/91
71122 Foggia
71122 Foggia
See on map
Region
Sud
Puglia
Foggia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giovanni Lovallo (Dr)
Links
Total cost
No data
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 549 000,00
Address
VIA MARIO NEGRI 2
20156 Milano
20156 Milano
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Region
Nord-Ovest
Lombardia
Milano
Activity type
Research Organisations
Administrative Contact
Slvio Garattinl (Prof)
Links
Total cost
No data
Innovative Concepts in Drug Development (ICDD-sas)
France
EU contribution
€ 298 423,00
Address
rte des Houillères —BP2
13590 Meyreuil
13590 Meyreuil
See on map
Administrative Contact
Laetitia Cruien (Mrs)
Links
Total cost
No data
SAS Alzprotect
France
EU contribution
€ 304 377,00
Address
rue du Docteur Yersin
59120 Loos
59120 Loos
See on map
Administrative Contact
Philippe Verwaerde (Dr)
Links
Total cost
No data
Qualissima
France
EU contribution
€ 544 752,00
Address
Rue Clapier
13001 Marseille
13001 Marseille
See on map
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Séverine Pitel (Dr)
Links
Total cost
No data
Diaxonhit SA
France
EU contribution
€ 259 677,00
Address
BOULEVARD MASSENA
75013 PARIS
75013 PARIS
See on map
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Veronique AUDOUARD (Ms)
Links
Total cost
No data
Innovative Health Diagnostics
Participation ended
France
EU contribution
€ 121 100,00
Address
Rue Blaise Pascal
67084 STRASBOURG
67084 STRASBOURG
See on map
Administrative Contact
XAVIER REGNAUT (Mr)
Links
Total cost
No data
ALZHEIMER EUROPE
Luxembourg
EU contribution
€ 100 000,00
Address
5 HEIENHAFF
1736 SENNINGERBERG
1736 SENNINGERBERG
See on map
Region
Luxembourg
Luxembourg
Luxembourg
Activity type
Research Organisations
Administrative Contact
Jean GEORGES (Mr)
Links
Total cost
No data
ASTRAZENECA AB
Sweden
EU contribution
No data
Address
Vastra Maelarhamnen
151 85 Sodertaelje
151 85 Sodertaelje
See on map
Region
Östra Sverige
Stockholm
Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Lindgren (Dr.)
Links
Total cost
No data
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
EU contribution
No data
Address
BINGER STRASSE
55218 Ingelheim
55218 Ingelheim
See on map
Region
Rheinland-Pfalz
Rheinhessen-Pfalz
Mainz-Bingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rolf Goggel (Dr.)
Links
Total cost
No data
NOVARTIS PHARMA AG
Switzerland
EU contribution
No data
Address
LICHTSTRASSE 35
4056 Basel
4056 Basel
See on map
Region
Schweiz/Suisse/Svizzera
Nordwestschweiz
Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ursula Knauf (Dr.)
Links
Total cost
No data
INSTITUT DE RECHERCHES SERVIER
France
EU contribution
No data
Address
22 ROUTE 128
91190 GIF-SUR-YVETTE
91190 GIF-SUR-YVETTE
See on map
Region
Ile-de-France
Ile-de-France
Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Esther Schenker (Dr)
Links
Total cost
No data
UCB PHARMA SA
Belgium
EU contribution
No data
Address
ALLEE DE LA RECHERCHE 60
1070 Bruxelles / Brussel
1070 Bruxelles / Brussel
See on map
Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest
Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Dresse (Mr.)
Links
Total cost
No data
MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
EU contribution
No data
Address
FRANKFURTER STRASSE 250
64293 Darmstadt
64293 Darmstadt
See on map
Region
Hessen
Darmstadt
Darmstadt, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ninog Peresse (-)
Links
Total cost
No data
ELI LILLY AND COMPANY LTD
United Kingdom
EU contribution
No data
Address
LILLY HOUSE BASINGVIEW
RG21 4FA Basingstoke
RG21 4FA Basingstoke
See on map
Region
South East (England)
Hampshire and Isle of Wight
North Hampshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Yates (Dr.)
Links
Total cost
No data
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
No data
Address
TURNHOUTSEWEG 30
2340 Beerse
2340 Beerse
See on map
Region
Vlaams Gewest
Prov. Antwerpen
Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Henk Sipma (Dr.)
Links
Total cost
No data
F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
No data
Address
GRENZACHERSTRASSE 124
4070 Basel
4070 Basel
See on map
Region
Schweiz/Suisse/Svizzera
Nordwestschweiz
Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Luca Santarelli (-)
Links
Total cost
No data
H. LUNDBECK AS
Denmark
EU contribution
No data
Address
OTTILIAVEJ 7-9
2500 Valby
2500 Valby
See on map
Region
Danmark
Hovedstaden
Byen København
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ejner Moltzen (ME)
Links
Total cost
No data
EISAI LIMITED
United Kingdom
EU contribution
No data
Address
EUROPEAN KNOWLEDGE CENTRE, MOSQUITO WAY
AL10 9SN Hatfield
AL10 9SN Hatfield
See on map
Region
East of England
Bedfordshire and Hertfordshire
Hertfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lee Dawson (Dr.)
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI GENOVA
Italy
EU contribution
€ 176 597,00
Address
VIA BALBI 5
16126 Genova
16126 Genova
See on map
Region
Nord-Ovest
Liguria
Genova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Laura Miano (Mrs)
Links
Total cost
No data
UNIVERSITY OF BRISTOL
Participation ended
United Kingdom
EU contribution
No data
Address
BEACON HOUSE QUEENS ROAD
BS8 1QU Bristol
BS8 1QU Bristol
See on map
Region
South West (England)
Gloucestershire, Wiltshire and Bristol/Bath area
Bristol, City of
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sarah everett-Cox (Mrs)
Links
Total cost
No data
IRCCS FONDAZIONE SDN PER LA RICERCA E L'ALTA FORMAZIONE IN DIAGNOSTICA NUCLEARE
Italy
EU contribution
€ 62 393,00
Address
via Emanuele Gianturco
80143 Napoli
80143 Napoli
See on map
Activity type
Research Organisations
Administrative Contact
Laura Recalina (Mrs)
Links
Total cost
No data
STICHTING VU
Netherlands
EU contribution
€ 44 000,00
Address
DE BOELELAAN 1105
1081 HV Amsterdam
1081 HV Amsterdam
See on map
Region
West-Nederland
Noord-Holland
Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Danielle Bonink (Ms)
Links
Total cost
No data
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 62 400,00
Address
LARGO GEMELLI 1
20123 Milano
20123 Milano
See on map
Region
Nord-Ovest
Lombardia
Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Filippo Leone (Mr)
Links
Total cost
No data
ELLINIKI ETAIRIA NOSOY ALZHEIMER KAI SYGGENON DIATARACHON SOMATEIO
Greece
EU contribution
€ 205 519,00
Address
PETROY SINDIKA 13
54643 Thessaloniki
54643 Thessaloniki
See on map
Region
Βόρεια Ελλάδα
Κεντρική Μακεδονία
Θεσσαλονίκη
Activity type
Other
Administrative Contact
Evi Siahoudi (Mrs)
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 304 400,00
Address
PIAZZA DELL UNIVERSITA 1
06123 Perugia
06123 Perugia
See on map
Region
Centro (IT)
Umbria
Perugia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lucia Farotti (Mrs)
Links
Total cost
No data
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
No data
Address
THE QUEEN'S DRIVE NORTHCOTE HOUSE
EX4 4QJ Exeter
EX4 4QJ Exeter
See on map
Region
South West (England)
Devon
Devon CC
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gaynor Hughes (Mrs)
Links
Total cost
No data