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Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in the early clinical development

Objective

PHARMA-COG aims to develop a new integrated model to accelerate the development of drug cindidates for MS, PKD and AD. The innovation relies on a 'multidimensional matrix' approach, integrating all available and renewed inputs (biomarkers/animal, human models/physiological and pharmcological challenges, Phase 0/1/1b to reduce the attrition rate, to allow an early and pertinent GO/NOGO decision before entering phase II trials for both symptomatic treatment and disease modifiers approaches. The hypothesis is that effective long term drugs will normalize markers artificially modified. The general objective is to test the efficiency of the 'matrix' on drug candidates for the enhancement/protection of cognitive functions. the final objective is to improve the detection and selection of new drugs candidates within a shorter teim-frame.
Our consortium gathers 13 academics and clinicians, 8 SMEs, 1 European patient organization (Alzheimer Europe) as well as 1 regulatory body (EMEA), coming form six different EU Members States. Excellence Centres gather representatives of the different sectors: biomarkers (proteomics, transcriptomics), pharmacodynamic markers ( electrophysiology, psychophysiology, morphological and functional imaging), preclinical model specialists (cellular, transgenic mouse, monkey), clinicians, and clinical pharmacologists.
By the end of this (-year project, the following achievements are expected; definition of the most predictive combination of pharmacodynamic markers; validation of parallel models (in healthy volunteers, ApoE 4 subjects,patients and animals) to establish effective exposure ranges and support proof of mechanism studies. The predictive value of the 'matrix' will be evaluated using different pharmacological target acting drugs. Suugestions for revised/new recomendations and guidellines will help to standardize the pre-clinical and clinical phases of drugs' development in neurodegenerative diseases.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /medical and health sciences/basic medicine/neurology/alzheimer

Call for proposal

IMI-JU-01-2008
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
Address
Great West Road 980
TW89GS Brentford
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Jill C Richardson (Dr.)
Administrative Contact
Graham Ian Somers (Dr.)

Participants (37)

UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 1 658 892
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Ms.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 560 973
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Pastora Martinez Samper (Mrs)
UNIVERSITE DE LILLE II - DROIT ET SANTE
France
EU contribution
€ 1 066 828
Address
Rue Paul Duez 42
59800 Lille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie GOMPEL (Dr.)
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 176 715
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tilman Hensch (Dr.)
UNIVERSIDAD DE MURCIA
Spain
EU contribution
€ 300 000
Address
Avenida Teniente Flomesta S/n - Edificio Convalecencia
30003 Murcia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Sanchez-Merenciano (Manager)
UNIVERSITAETSKLINIKUM ESSEN
Germany
EU contribution
€ 70 748
Address
Hufelandstrasse 55
45147 Essen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Willibald Kroening (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 205 000
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Julie Zitel (Mrs)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 010 591
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Armelle Barelli (Mrs)
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 360 000
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Manuela Calderara (Ms)
PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI
Italy
EU contribution
€ 767 507
Address
Via Pilastroni 4
25125 Brescia
Activity type
Research Organisations
Administrative Contact
Fra Marco Fabello (-)
UNIVERSITA DEGLI STUDI DI FOGGIA
Italy
EU contribution
€ 448 496
Address
Via Gramsci 89/91
71122 Foggia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giovanni Lovallo (Dr)
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 549 000
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Administrative Contact
Slvio Garattinl (Prof)
Innovative Concepts in Drug Development (ICDD-sas)
France
EU contribution
€ 298 423
Address
Rte Des Houillères —Bp2
13590 Meyreuil
Administrative Contact
Laetitia Cruien (Mrs)
SAS Alzprotect
France
EU contribution
€ 304 377
Address
Rue Du Docteur Yersin
59120 Loos
Administrative Contact
Philippe Verwaerde (Dr)
Qualissima
France
EU contribution
€ 544 752
Address
Rue Clapier
13001 Marseille
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Séverine Pitel (Dr)
Diaxonhit SA
France
EU contribution
€ 259 677
Address
Boulevard Massena
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Veronique AUDOUARD (Ms)
Innovative Health Diagnostics

Participation ended

France
EU contribution
€ 121 100
Address
Rue Blaise Pascal
67084 Strasbourg
Administrative Contact
XAVIER REGNAUT (Mr)
ALZHEIMER EUROPE
Luxembourg
EU contribution
€ 100 000
Address
Rue Dicks 14
1417 Luxembourg
Activity type
Other
Administrative Contact
Jean GEORGES (Mr)
ASTRAZENECA AB
Sweden
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Lindgren (Dr.)
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Address
Binger Strasse
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rolf Goggel (Dr.)
NOVARTIS PHARMA AG
Switzerland
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ursula Knauf (Dr.)
INSTITUT DE RECHERCHES SERVIER
France
Address
3 Rue De La Republique
92150 Suresnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Esther Schenker (Dr)
UCB PHARMA SA
Belgium
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Dresse (Mr.)
Merck KGaA
Germany
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ninog Peresse (-)
Eli Lilly and Company Limited
United Kingdom
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Yates (Dr.)
JANSSEN PHARMACEUTICA NV
Belgium
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Henk Sipma (Dr.)
F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Luca Santarelli (-)
H. LUNDBECK AS
Denmark
Address
Ottiliavej 7-9
2500 Valby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ejner Moltzen (ME)
EISAI LIMITED
United Kingdom
Address
European Knowledge Centre, Mosquito Way
AL10 9SN Hatfield
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lee Dawson (Dr.)
UNIVERSITA DEGLI STUDI DI GENOVA
Italy
EU contribution
€ 176 597
Address
Via Balbi 5
16126 Genova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Laura Miano (Mrs)
UNIVERSITY OF BRISTOL

Participation ended

United Kingdom
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sarah everett-Cox (Mrs)
IRCCS FONDAZIONE SDN PER LA RICERCA E L'ALTA FORMAZIONE IN DIAGNOSTICA NUCLEARE
Italy
EU contribution
€ 62 393
Address
Via Emanuele Gianturco
80143 Napoli
Activity type
Research Organisations
Administrative Contact
Laura Recalina (Mrs)
STICHTING VU
Netherlands
EU contribution
€ 44 000
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Danielle Bonink (Ms)
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 62 400
Address
Largo Gemelli 1
20123 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Filippo Leone (Mr)
ELLINIKI ETAIRIA NOSOY ALZHEIMER KAI SYGGENON DIATARACHON SOMATEIO
Greece
EU contribution
€ 205 519
Address
Petroy Sindika 13
54643 Thessaloniki
Activity type
Other
Administrative Contact
Evi Siahoudi (Mrs)
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 304 400
Address
Piazza Dell Universita 1
06123 Perugia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lucia Farotti (Mrs)
THE UNIVERSITY OF EXETER
United Kingdom
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gaynor Hughes (Mrs)