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Drug Disease Model Resources

Objective

Model based-drug development (MBDD) is accepted as a vital approach in understanding patient risk/benefit and attrition. At the core of MBDD lies Modelling and Simulation (M&S), a technology providing the basis for informed, quantitative decision-making.

M&S facilitates the continuous integration of available information related to a drug or disease into constantly-evolving mathematical models capable of describing and predicting the behaviour of studied systems to address the questions researchers, regulators, and public health care bodies face when bringing drugs to patients.

The full adoption of MBDD is frustrated by a lack of common tools, languages and ontologies for M&S, which often leads to inefficient reuse of data and duplication of effort by academic, industrial and regulatory stakeholders.

The Drug Disease Model Resources (DDMoRe) consortium’s strategy will have standards as its core: a newly developed common definition language for data, models and workflows, along with an ontology based standard for storage and transfer of models and associated metadata.

A drug and disease model library will be developed as a public resource. Its flexibility and power will be showcased by the addition of “proof of concept” drug and disease models from key therapeutic areas such as diabetes and oncology.

An open-source interoperability framework will be the backbone for the integration of M&S applications into seamless, standardized but flexible workflows. Initially, currently-used tools (e.g. NONMEM, WinBUGS, Matlab, R) will be integrated into the framework. From the outset resources will also be dedicated to new application development which will be steered by identified gaps in the M&S software ecosystem.

The DDMoRe project’s standards and tools – intended as the gold standard for future collaborative drug and disease M&S - will be supported by comprehensive training and will be made publicly accessible.

Field of science

  • /humanities/languages and literature/languages - general

Call for proposal

IMI-JU-02-2009
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

PFIZER LIMITED
Address
Ramsgate Road
CT13 9NJ Sandwich
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Lutz Harnisch (Dr)
Administrative Contact
Olga Krylova (Dr.)

Participants (27)

UPPSALA UNIVERSITET
Sweden
EU contribution
€ 1 805 231
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marina Rönngren (Mrs)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 1 391 410
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Tom Ratcliff (Mr)
Mango Business Solutions Limited
United Kingdom
EU contribution
€ 1 794 522
Address
Suite 3 Middlesex House, Rutherford Close
SG1 2EF Stevenage
Administrative Contact
Nicola Carley (Mrs)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 1 103 588
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ton Brouwer (Mr)
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 942 620
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sofia Baggini (Dr)
INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE
France
EU contribution
€ 570 533
Address
Domaine De Voluceau Rocquencourt
78153 Le Chesnay Cedex
Activity type
Research Organisations
Administrative Contact
Mireille Moulin (Ms.)
CERTARA UK LIMITED
United Kingdom
EU contribution
€ 145 000
Address
One London Wall 6Th Floor
EC2Y 5EB London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Zoe Kelly (Ms)
CYPROTEX DISCOVERY LIMITED
United Kingdom
EU contribution
€ 333 357
Address
114 Innovation Drive Milton Park
OX14 4RZ Abingdon Oxfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mark Warburton (Mr)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 358 628
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Michela Matteoli (Prof)
MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

Participation ended

Germany
EU contribution
€ 1 182
Address
Universitaetsplatz 10
6108 Halle (Saale)
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sigrid Köhne (Dr.)
UNIVERSITE PARIS DIDEROT - PARIS 7
France
EU contribution
€ 308 651
Address
Rue Thomas Mann 5
75205 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Muriel Maurice (Ms)
UNIVERSIDAD DE NAVARRA
Spain
EU contribution
€ 189 312
Address
Campus Universitario Edificio Central
31080 Pamplona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Iñigo Uriarte-Pueyo (Dr)
OPTIMATA LTD
Israel
EU contribution
€ 147 278
Address
20 Zichron Yaa'kov St.
6299920 Tel Aviv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Agur (Mr)
NOVARTIS PHARMA AG
Switzerland
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heike Wachenhausen (Mrs)
ASTRAZENECA AB
Sweden
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Lindgren (Mrs)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elaine Alison Irving (Dr)
Eli Lilly and Company Limited
United Kingdom
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Steckel-Hamann (Dr)
Merck KGaA
Germany
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ninog Peresse (Dr.)
NOVO NORDISK A/S
Denmark
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jorgen Dirach (Dr)
F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jason Hannon (Dr)
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS
France
Address
Rue Carnot 50
92284 Courbevoie
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daniel Courtois (Mr)
UCB PHARMA SA
Belgium
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Dresse (Mr)
Interface Europe

Participation ended

Belgium
EU contribution
€ 477 891
Address
Rue Du Trone 12
1000 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marc Loher (Mr)
FREIE UNIVERSITAET BERLIN
Germany
EU contribution
€ 369 910
Address
Kaiserswerther Strasse 16-18
14195 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carsten Malmwieck (Mr)
LIXOFT SAS
France
EU contribution
€ 270 753
Address
8 Rue De La Renaissance Batiment D
92160 Antony
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jérôme Kalifa (Dr)
University College London
United Kingdom
EU contribution
€ 189 560
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Malgorzata Kielbasa (Ms)
TAKEDA PHARMACEUTICALS INTERNATIONAL AG
Switzerland
Address
Thurgauerstrasse 130
8152 Glattpark
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gezim Lahu (Senior Director, PhD)