Objective We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therapeutic agents that are being developed for one disease but cannot be applied in another due to current clinical classifications. We will investigate individuals with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren’s syndrome (Sjs), rheumatoid arthritis (RA), primary antiphospholipid syndrome (PAPS) and mixed connective tissue disease (MCTD), jointly as systemic autoimmune diseases (SADs). We believe that there will be overlapping clusters of individuals across diseases that will share molecular features. To determine these clusters we will, study 2000 cases of SADs, and 600 healthy controls to identify molecular clusters and their cellular and clinical correlates. In addition, we will study kidney and skin biopsies to define the development of molecular markers with severe kidney disease or with skin fibrosis. In this way we will define systemic and tissue taxonomies. We will study complete as well as isolated peripheral blood mononuclear cells and subpopulations and in biopsies gene expression and epigenetic marks with a combination of array and next generation sequencing (NGS) strategies. These studies will define cellular counts and proportions and changes in gene expression related to specific cellular populations. We will also use NGS strategies to define the presence of risk alleles (HLA and non-HLA) in all individuals. The data will be complemented with the study of the presence of autoantibodies in serum (analyzed in a reference lab), and we will use metabolomics mass spectrometry and NMR approaches to analyze plasma and urine metabolites. We will also study exosomes in plasma and urine and identify their molecular profiles. Samples will be collected following strict protocols and appropriate patient selection. The bioinformatics and biostatistics approaches will be aimed at the analysis of clusters with unsupervised clustering algorithms and tools and cross-validation. We will also perform analyses to determine risk and predictive models analyzing the genetic and molecular data at different levels, leading to a highly productive study with two arms, one for basic research and one with clinical applications. Among the clinical applications we will have a new classification for groups of patients sharing molecular mechanisms of disease, biomarkers for disease progression and organ damage prediction, and we will develop assays that can be easily applied in the clinic. The resultant clinically applicable clusters will be then validated in a longitudinal, inception trial where newly recruited patients will be analyzed at baseline and at two different time points and define their clustering status or their evolution towards specific clusters.We will gain completely novel information that will open new avenues of research and new possibilities of collaboration between the public Academy and the private Pharmaceutical sector by establishing the basis for new clinical trials with the potential to really benefit the patients. Fields of science medical and health sciencesclinical medicinerheumatologynatural sciencesbiological sciencescell biologymedical and health sciencesbasic medicineimmunologyautoimmune diseasesnatural scienceschemical sciencesanalytical chemistrymass spectrometrymedical and health sciencesclinical medicinenephrologykidney diseases Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-08-2012-03 - Developing An Aetiology-Based Taxonomy Of Human Disease - Approaches to Develop a New Classification for Systemic Lupus Erythematosus (SLE) and Related Connective Tissue Disorders and Rheumatoid Arthritis (RA) Call for proposal IMI-JU-08-2012 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator UCB BIOPHARMA EU contribution No data Address ALLEE DE LA RECHERCHE 60 1070 Bruxelles / Brussel Belgium See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Principal investigator John Ioannou (Dr) Administrative Contact Katharina Klapper (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (28) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD M.P. Spain EU contribution € 1 826 852,00 Address AVENIDA AMERICO VESPUCIO 15 EDIF S2 41092 Sevilla See on map Region Sur Andalucía Sevilla Activity type Research Organisations Administrative Contact Enrique Sanchez Suarez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ATRYS HEALTH, SA Spain EU contribution € 243 425,00 Address CALLE VELAZQUEZ 24 4 IZQUIERDA 28001 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Encarna Vega (Mr.) Links Contact the organisation Opens in new window Total cost No data CENTRO HOSPITALAR UNIVERSITARIO DO PORTO EPE Portugal EU contribution € 153 324,00 Address LARGO PROFESSOR ABEL SALAZAR 4099 001 Porto See on map Region Continente Norte Área Metropolitana do Porto Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ana Isabel Tavares (Ms) Links Contact the organisation Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 846 180,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact María Requejo (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO Italy EU contribution € 388 612,00 Address VIA FRANCESCO SFORZA 28 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Other Administrative Contact Manuela Martorana (MRS) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE Spain EU contribution € 1 026 782,00 Address AVENIDA GRAN VIA HOSPITALET 199-203 08908 L'Hospitalet De Llobregat See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact LAIA LAGUNAS (MRS.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Servicio Cántabro de Salud Spain EU contribution € 127 950,00 Address Avenida de Cardenal Herrera Oria Santander See on map Region Noroeste Cantabria Cantabria Activity type Research Organisations Administrative Contact Raquel Leal (Technician) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain EU contribution € 145 320,00 Address CALLE ROSSELLO 149 PUERTA BJS 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Other Administrative Contact Pastora Martínez Samper (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 434 450,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Anna Frostegård (MD, PhD, Leg.Läk) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 229 400,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Karolien Mariën (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM DER UNIVERSITAET ZU KOELN Germany EU contribution € 129 800,00 Address Kerpener Strasse 62 50937 Koeln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Petra Schreiner-Kaub (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE HOCHSCHULE HANNOVER Germany EU contribution € 217 924,00 Address Carl-Neuberg-Strasse 1 30625 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Higher or Secondary Education Establishments Administrative Contact Simone Hess (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAET WIEN Austria EU contribution € 45 520,00 Address SPITALGASSE 23 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Michaela Ernst (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Quartz Bio S.A. Switzerland EU contribution € 893 562,00 Address Chemin du Pré-Fleuri 1228 Plan-les-Ouates See on map Administrative Contact Jérôme Wojcik (CEO) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SERVICIO ANDALUZ DE SALUD Spain EU contribution € 556 740,00 Address AVENIDA DE LA CONSTITUCION 18 41071 Sevilla See on map Region Sur Andalucía Sevilla Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Elena Martin-Bautista (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KYPRIAKO IDRYMA EREVNON GIA TI MYIKI DISTROFIA Cyprus EU contribution € 252 540,00 Address 6 IROON AVENUE 2371 AGIOS DOMETIOS See on map Region Κύπρος Κύπρος Κύπρος Activity type Research Organisations Administrative Contact Marios Flouros (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD DE GRANADA Spain EU contribution € 480 780,00 Address CUESTA DEL HOSPICIO SN 18071 Granada See on map Region Sur Andalucía Granada Activity type Higher or Secondary Education Establishments Administrative Contact Jose A. Carrillo Miñán (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI MILANO Italy EU contribution € 254 040,00 Address Via Festa Del Perdono 7 20122 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Anna Maria Cerini (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium EU contribution € 341 995,00 Address PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Administrative Contact Geneviève Depresseux (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE BRETAGNE OCCIDENTALE France EU contribution € 638 199,00 Address RUE MATTHIEU GALLOU 3 29238 BREST See on map Region Bretagne Bretagne Finistère Activity type Higher or Secondary Education Establishments Administrative Contact Nathalie Queffelec (Ingénieur Europe) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE GENEVE Switzerland EU contribution € 270 140,00 Address RUE DU GENERAL DUFOUR 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Carlo CHIZZOLINI (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SZEGEDI TUDOMANYEGYETEM Hungary EU contribution € 67 350,00 Address DUGONICS TER 13 6720 Szeged See on map Region Alföld és Észak Dél-Alföld Csongrád Activity type Higher or Secondary Education Establishments Administrative Contact Gabor Antal (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DEUTSCHES RHEUMA FORSCHUNGSZENTRUMBERLIN Participation ended Germany EU contribution € 49 453,00 Address CHARITEPLATZ 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Research Organisations Administrative Contact Petra Starke (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BAYER AKTIENGESELLSCHAFT Germany EU contribution No data Address KAISER-WILHELM-ALLEE 1 51373 Leverkusen See on map Region Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Petra Freitag (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS France EU contribution No data Address RUE CARNOT 50 92284 Courbevoie See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marie DUVICQ (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France EU contribution No data Address 82 AVENUE RASPAIL 94250 GENTILLY See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Thorsten Strube (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ELI LILLY AND COMPANY LTD United Kingdom EU contribution No data Address LILLY HOUSE BASINGVIEW RG21 4FA Basingstoke See on map Region South East (England) Hampshire and Isle of Wight North Hampshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Steckel-Hamann (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 378 985,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fräßdorf (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data