Objectif We are proposing to develop a molecular assay for the safe, rapid, specific and sensitive detection of Ebola Virus Infection in capillary (or venous) blood samples combining ALTONA’s Pan-filo screening IVD test with the existing Alere™ q point of care molecular diagnostics platform. The purpose of this project is to utilize existing and proven PCR assay(s) designed for laboratory use and to take advantage of the Alere™ q point of care molecular instrument and cartridge design to simplify Ebola testing so that molecular testing can be expanded to sites beyond which high end laboratory infrastructure is not available while simultaneously greatly reducing infection risk for the test operator. The project aims for the fast development of a point of care Nucleic Acid Test (POC-NAT) system for filovirus specific RNA, from human sample material, especially from blood samples. The POC-NAT system will have the following features:1. Field proven stand alone, mobile and easy to use instrumentation2. ready to use cartridge, safely disposable nucleic acid test format with integrated sample preparation3. assay for specific detection of RNA of all known species from the virus genera Ebola- and Marburgvirus .4. process duration from sampling to result less than 45 min5. no additional equipment and no logistics and storage at -20°C neededThe POC-NAT is based on two already existing technologies: The instrument platform “Alere™q complete” developed and manufactured by Alere , an instrument for POC diagnostics recently used p.e. for Alere´s HIV-1/2 Detect cartridges, and altona Diagnostics´ RealStar® Filovirus RT-PCR kit 1.0 a commercial central laboratory real-time PCR test. The project partner aim for having the integration of platform and assay as a prototypic system completed until end of March 2015. The verification and validation of the workflow starts April 2015 at altona Diagnostics, BNITM and INMI. The aim of this project phase is to finally CE IVD mark the test system Champ scientifique sciences médicales et de la santésciences de la santésanté publique et environnementalesciences naturellessciences biologiquesbiochimiebiomoléculeacide nucléiquesciences naturellessciences biologiquesmicrobiologievirologiesciences médicales et de la santésciences de la santémaladie infectieusevirus à ARNebolasciences naturellessciences biologiquesgénétiqueARN Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2) Thème(s) IMI2-2014-02-05 - Rapid diagnostic tests Appel à propositions H2020-JTI-IMI2-2014-02-single-stage Voir d’autres projets de cet appel Régime de financement IMI2-RIA - Research and Innovation action Coordinateur Department of Health Contribution nette de l'UE € 332 460,00 Adresse Quarry house, quarry hill LS2 7UE Leeds Royaume-Uni Voir sur la carte Région Yorkshire and the Humber West Yorkshire Leeds Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 Participants (5) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire ALTONA DIAGNOSTICS GMBH Allemagne Contribution nette de l'UE € 394 178,00 Adresse Morkenstrasse 12 22767 Hamburg Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Hamburg Hamburg Hamburg Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 ALERE TECHNOLOGIES GMBH Allemagne Contribution nette de l'UE € 0,00 Adresse Lobstedter str 103 105 07749 Jena Voir sur la carte Région Thüringen Thüringen Jena, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 1 936 002,00 BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Allemagne Contribution nette de l'UE € 217 992,00 Adresse Bernhard nocht strasse 74 20359 Hamburg Voir sur la carte Région Hamburg Hamburg Hamburg Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO Italie Contribution nette de l'UE € 217 992,00 Adresse Via portuense, 292 00149 Roma Voir sur la carte Région Centro (IT) Lazio Roma Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS Suisse Contribution nette de l'UE € 0,00 Adresse Campus biotech, chemin des mines 9 1202 Geneve Voir sur la carte Région Schweiz/Suisse/Svizzera Région lémanique Genève Type d’activité Other Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 1 299 628,00
