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Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881

Objective

The stated goal of RHAPSODY is to define a molecular taxonomy of type 2 diabetes mellitus (T2D) that will support patient segmentation, inform clinical trial design, and the establishment of regulatory paths for the adoption of novel strategies for diabetes prevention and treatment. To address these goals, RHAPSODY will bring together prominent European experts, including the leaders of the diabetes-relevant IMI1 projects to identify, validate and characterize causal biomarkers for T2D subtypes and progression. Our plans are built upon: (a) access to large European cohorts with comprehensive genetic analyses and rich longitudinal clinical and biochemical data and samples; (b) detailed multi-omic maps of key T2D-relevant tissues and organs; (c) large expertise in the development and use of novel genetic, epigenetic, biochemical and physiological experimental approaches; (d) the ability to combine existing and novel data sets through effective data federation and use of these datasets in systems biology approaches towards precision medicine; and (e) expertise in regulatory approval, health economics and patient engagement. These activities will lead to the discovery of novel biomarkers for improved T2D taxonomy, to support development of pharmaceutical activities, and for use in precision medicine to improve health in Europe and worldwide.

Field of science

  • /social sciences/economics and business/economics
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /social sciences/economics and business

Call for proposal

H2020-JTI-IMI2-2015-03-two-stage
See other projects for this call

Funding Scheme

IMI2-RIA - Research and Innovation action

Coordinator

UNIVERSITE DE LAUSANNE
Address
Quartier Unil-centre Bâtiment Unicentre
1015 Lausanne
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 109 706

Participants (27)

LUNDS UNIVERSITET
Sweden
EU contribution
€ 1 071 853
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 518 723
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DI PISA
Italy
EU contribution
€ 435 663
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE PARIS
France
EU contribution
€ 503 970
Address
85 Bd Saint Germain
75006 Paris
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 408 745
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 439 645
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
SIB INSTITUT SUISSE DE BIOINFORMATIQUE
Switzerland
EU contribution
€ 187 500
Address
Rue Michel Servet 1 Cmu
1206 Geneve
Activity type
Research Organisations
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 251 936,09
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 468 923
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 244 943,69
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 499 121,25
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 668 523,30
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 389 966
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
LIPOTYPE
Germany
EU contribution
€ 418 969
Address
Tatzberg 47
01307 Dresden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 599 151
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
AZIENDA OSPEDALIERA CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO
Italy
EU contribution
€ 104 743
Address
Corso Bramante 88 90
10126 Torino
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 54 868,67
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE
France
EU contribution
€ 299 296
Address
Avenue Oscar Lambret 2
59037 Lille
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 149 632
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
SCIPROM SARL
Switzerland
EU contribution
€ 23 750
Address
Rue Du Centre 70
1025 Saint Sulpice
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECHERCHES SERVIER
France
EU contribution
€ 0
Address
3 Rue De La Republique
92150 Suresnes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 0
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVO NORDISK A/S
Denmark
EU contribution
€ 0
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
EU contribution
€ 0
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING VUMC
Netherlands
EU contribution
€ 194 983
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
Eli Lilly and Company Limited
United Kingdom
EU contribution
€ 0
Address
Lilly House, Priestley Road
RG24 9NL Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 85 389
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments