Deliverables Documents, reports (5) Satellite conference Migration Integrated model of pre-diabetes and T2D populations Integrated model of prediabetes and T2D populations Assessment of insulin action and secretion in preclinical models Migration Economic model of pre-diabetes populations Economic model of pre-diabetes populations Health technology assessment of new biomarker technologies at the early stages of development and dissemination Health technology assessment of new biomarker technologies at the early stages of development and dissemination. Websites, patent fillings, videos etc. (3) Project flyer Migration Website Migration Sustainable platform Webbased platform online and accessible Publications Peer reviewed articles (76) Elevated circulating follistatin associates with an increased risk of type 2 diabetes Author(s): Wu, Chuanyan; Borné, Yan; Gao, Rui; López Rodriguez, Maykel; Roell, William C.; Wilson, Jonathan M.; Regmi, Ajit; Luan, Cheng; Aly, Dina Mansour; Peter, Andreas; Machann, Jürgen; Staiger, Harald; Fritsche, Andreas; Birkenfeld, Andreas L.; Tao, Rongya; Wagner, Robert; Canouil, Mickaël; Hong, Mun-Gwan; Schwenk, Jochen M.; Ahlqvist, Emma; Kaikkonen, Minna U.; Nilsson, Peter; Shore, Angela C.; Kha Published in: Nature Communications, Issue 12, 2021, Page(s) 6486, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-26536-w An investigation of causal relationships between prediabetes and vascular complications Author(s): Mutie, Pascal M.; Pomares-Millan, Hugo; Atabaki-Pasdar, Naeimeh; Jordan, Nina; Adams, Rachel; Daly, Nicole L.; Tajes, Juan Fernandes; Giordano, Giuseppe N.; Franks, Paul W. Published in: Nature Communications, Issue 11, 2020, Page(s) 4592, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-18386-9 3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells Author(s): Müller, Andreas; Schmidt, Deborah; Xu, C. Shan; Pang, Song; D’Costa, Joyson Verner; Kretschmar, Susanne; Münster, Carla; Kurth, Thomas; Jug, Florian; Weigert, Martin; Hess, Harald F.; Solimena, Michele Published in: Journal of Cell Biology, Issue 220, 2021, Page(s) 0021-9525, 1540-8140, ISSN 0021-9525 Publisher: Rockefeller University Press DOI: 10.1083/jcb.202010039 Prediction of mortality and major cardiovascular complications in type 2 diabetes: External validation of UK Prospective Diabetes Study outcomes model version 2 in two European observational cohorts Author(s): Eva Pagano, Stefan R. A. Konings, Daniela Di Cuonzo, Rosalba Rosato, Graziella Bruno, Amber A. Heijden, Joline Beulens, Roderick Slieker, Jose Leal, Talitha L. Feenstra Published in: Diabetes, Obesity and Metabolism, 2021, ISSN 1462-8902 Publisher: Blackwell Publishing Inc. DOI: 10.1111/dom.14311 Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes Author(s): Lytrivi, Maria; Castell, Anne-Laure; Poitout, Vincent; Cnop, Miriam Published in: Journal of Molecular Biology, Issue 432, 2020, Page(s) 1514-1534, ISSN 0022-2836 Publisher: Academic Press DOI: 10.1016/j.jmb.2019.09.016 Evaluating the Ability of Economic Models of Diabetes to Simulate New Cardiovascular Outcomes Trials: A Report on the Ninth Mount Hood Diabetes Challenge Author(s): Si, Lei; Willis, Michael S.; Asseburg, Christian; Nilsson, Andreas; Tew, Michelle; Clarke, Philip M.; Lamotte, Mark; Ramos, Mafalda; Shao, Hui; Shi, Lizheng; Zhang, Ping; McEwan, Phil; Ye, Wen; Herman, William H.; Kuo, Shihchen; Isaman, Deanna J.; Schramm, Wendelin; Sailer, Fabian; Brennan, Alan; Pollard, Daniel; Smolen, Harry J.; Leal, José; Gray, Alastair; Patel, Rishi; Feenstra, Talitha; Palme Published in: Value in Health, Issue 23, 2020, Page(s) 1163-1170, ISSN 1098-3015 Publisher: Blackwell Publishing Inc. DOI: 10.1016/j.jval.2020.04.1832 Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice Author(s): Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-25423-8 Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets Author(s): Latif Rachdi, Alicia Maugein, Severine Pechberty, Mathieu Armanet, Juliette Hamroune, Philippe Ravassard, Stefano Marullo, Olivier Albagli, Raphael Scharfmann Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322 Publisher: Nature Publishing Group DOI: 10.1038/s41598-020-69758-6 Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence Author(s): Neha Shrestha, Elisa De Franco, Peter Arvan, Miriam Cnop Published in: Frontiers in Endocrinology, Issue 12, 2021, ISSN 1664-2392 Publisher: frontiers DOI: 10.3389/fendo.2021.650158 Sequential in vivo labeling of insulin secretory granule pools in INS - SNAP transgenic pigs Author(s): Elisabeth Kemter, Andreas Müller, Martin Neukam, Anna Ivanova, Nikolai Klymiuk, Simone Renner, Kaiyuan Yang, Johannes Broichhagen, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Klaus-Peter Knoch, Marc Bickle, Barbara Ludwig, Kai Johnsson, Heiko Lickert, Thomas Kurth, Eckhard Wolf, Michele Solimena Published in: Proceedings of the National Academy of Sciences, Issue 118/37, 2021, Page(s) e2107665118, ISSN 0027-8424 Publisher: National Academy of Sciences DOI: 10.1073/pnas.2107665118 Metabolic and functional heterogeneity in pancreatic β cells Author(s): Gabriela da Silva Xavier; Guy A. Rutter Published in: Journal of Molecular Biology, 2020, ISSN 0022-2836 Publisher: Academic Press DOI: 10.1016/j.jmb.2019.08.005 Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes Author(s): Leonore Wigger, Marko Barovic, Andreas-David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frederic Burdet, Camille Kessler, Mathias Lesche, Bernard Thorens, Ezio Bonifacio, Cristina Legido-Quigley, Pierre Barbier Saint Hilaire, Philippe Delerive, Andreas Dahl, Christian Klose, Mathias J. Gerl, Kai Simons, Daniela Aust, Jürgen Weitz, Marius Distler, An Published in: Nature Metabolism, Issue 3/7, 2021, Page(s) 1017-1031, ISSN 2522-5812 Publisher: Nature DOI: 10.1038/s42255-021-00420-9 Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes Author(s): Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Pe Published in: Cell Reports, Issue 33/9, 2020, Page(s) 108466, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2020.108466 Glucocorticoid Metabolism in Obesity and Following Weight Loss. Author(s): Elina Akalestou; Laurent Genser; Laurent Genser; Guy A. Rutter Published in: Frontiers in Endocrinology, Issue 12, 2020, ISSN 1664-2392 Publisher: Frontiers Media DOI: 10.3389/fendo.2020.00059 Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity Author(s): Lytrivi, Maria; Ghaddar, Kassem; Lopes, Miguel; Rosengren, Victoria; Piron, Anthony; Yi, Xiaoyan; Johansson, Henrik; Lehtiö, Janne; Igoillo-Esteve, Mariana; Cunha, Daniel A.; Marselli, Lorella; Marchetti, Piero; Ortsäter, Henrik; Eizirik, Decio L.; Cnop, Miriam Published in: BMC Genomics, 2020, ISSN 1471-2164 Publisher: BioMed Central DOI: 10.1186/s12864-020-07003-0 A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice Author(s): Chloé Amouyal, Julien Castel, Claudiane Guay, Amélie Lacombe, Jessica Denom, Stéphanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides, Serge Luquet, Hervé Le Stunff, Raphael Scharfmann, Karine Clément, Guy A. Rutter, Olivier Taboureau, Christophe Magnan, Romano Regazzi, Fabrizio Andreelli Published in: EBioMedicine, Issue 58, 2020, Page(s) 102895, ISSN 2352-3964 Publisher: Elsevier BV DOI: 10.1016/j.ebiom.2020.102895 Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes Author(s): Marko Barovic, Marius Distler, Eyke Schöniger, Nicole Radisch, Daniela Aust, Jürgen Weitz, Mark Ibberson, Anke M. Schulte, Michele Solimena Published in: Molecular Metabolism, Issue 27, 2019, Page(s) S1-S6, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2019.06.006 Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists Author(s): Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones Published in: Molecular Metabolism, Issue 37, 2020, Page(s) 100991, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2020.100991 Mechanisms of Weight Loss After Obesity Surgery Author(s): Elina Akalestou, Alexander D Miras, Guy A Rutter, Carel W le Roux Published in: Endocrine Reviews, 2021, ISSN 0163-769X Publisher: The Endocrine Society DOI: 10.1210/endrev/bnab022 Transcription factors that shape the mammalian pancreas Author(s): Jennings, Rachel E.; Scharfmann, Raphael; Staels, Willem Published in: Diabetologia, Issue 63, 2020, Page(s) 1974-1980, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-020-05161-0 Plasma triacylglycerols are biomarkers of ß-cell function in mice and humans Author(s): Ana Rodríguez Sánchez-Archidona, Céline Cruciani-Guglielmacci, Clara Roujeau, Leonore Wigger, Justine Lallement, Jessica Denom, Marko Barovic, Nadim Kassis, Florence Mehl, Jurgen Weitz, Marius Distler, Christian Klose, Kai Simons, Mark Ibberson, Michele Solimena, Christophe Magnan, Bernard Thorens Published in: Molecular Metabolism, 2021, Page(s) 101355, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2021.101355 Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort Author(s): Roderick C. Slieker, Amber A. W. H. van der Heijden, Giel Nijpels, Petra J. M. Elders, Leen M. ’t Hart, Joline W. J. Beulens Published in: Cardiovascular Diabetology, Issue 18/1, 2019, ISSN 1475-2840 Publisher: BioMed Central DOI: 10.1186/s12933-019-0975-1 Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data Author(s): Jose Leal, Shelby D. Reed, Rishi Patel, Oliver Rivero-Arias, Yanhong Li, Kevin A. Schulman, Robert M. Califf, Rury R. Holman, Alastair M. Gray Published in: Diabetes Care, Issue 43/10, 2020, Page(s) 2485-2492, ISSN 0149-5992 Publisher: American Diabetes Association DOI: 10.2337/dc20-0717 Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes Author(s): Bosi, Emanuele; Marselli, Lorella; De Luca, Carmela; Suleiman, Mara; Tesi, Marta; Ibberson, Mark; Eizirik, Decio L.; Cnop, Miriam; Marchetti, Piero Published in: NAR genomics and bioinformatics, Issue 2, 2020, Page(s) lqaa097, ISSN 2631-9268 Publisher: Oxford University Press DOI: 10.1093/nargab/lqaa097 The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice Author(s): Georgiadou, Eleni; Haythorne, Elizabeth; Dickerson, Matthew T.; Lopez-Noriega, Livia; Pullen, Timothy J.; da Silva Xavier, Gabriela; Davis, Samuel P. X.; Martinez-Sanchez, Aida; Semplici, Francesca; Rizzuto, Rosario; McGinty, James A.; French, Paul M.; Cane, Matthew C.; Jacobson, David A.; Leclerc, Isabelle; Rutter, Guy A. Published in: Diabetologia, Issue 63, 2020, Page(s) 1368-1381, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-020-05148-x The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists Author(s): Zijian Fang; Shiqian Chen; Philip Pickford; Johannes Broichhagen; David J. Hodson; David J. Hodson; Ivan R. Corrêa; Sunil Kumar; Frederik Görlitz; Christopher Dunsby; Paul M. W. French; Guy A. Rutter; Tricia Tan; Stephen R. Bloom; Alejandra Tomas; Ben Jones Published in: ACS Pharmacol Transl Sci, Issue 16, 2020, ISSN 2575-9108 Publisher: ACS Publications DOI: 10.1021/acsptsci.0c00022 Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure Author(s): Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop Published in: Nature Reviews Endocrinology, Issue 16/7, 2020, Page(s) 349-362, ISSN 1759-5029 Publisher: Nature Publishing Group DOI: 10.1038/s41574-020-0355-7 Performance of the UKPDS Outcomes Model for Prediction of Myocardial Infarction and Stroke in the ADDITION-Europe Trial Cohort Author(s): Libo Tao, Edward C.F. Wilson, Simon J. Griffin, Rebecca K. Simmons Published in: Value in Health, Issue 16/6, 2013, Page(s) 1074-1080, ISSN 1098-3015 Publisher: Blackwell Publishing Inc. DOI: 10.1016/j.jval.2013.06.001 Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function Author(s): Livia López–Noriega, Guy A. Rutter Published in: Frontiers in Endocrinology, Issue 11, 2021, ISSN 1664-2392 Publisher: Frontiers in endocrinology DOI: 10.3389/fendo.2020.610213 Estimating risk factor progression equations for the UKPDS Outcomes Model 2 (UKPDS 90) Author(s): Jose Leal, Maria Alva, Vanessa Gregory, Alison Hayes, Borislava Mihaylova, Alastair M. Gray, Rury R. Holman, Philip Clarke Published in: Diabetic Medicine, Issue 38/10, 2021, ISSN 0742-3071 Publisher: Blackwell Publishing Inc. DOI: 10.1111/dme.14656 Détection cérébrale du glucose et homéostasie du glucose Author(s): Bernard Thorens, Gwenaël Labouèbe Published in: Médecine des Maladies Métaboliques, Issue 15/5, 2021, Page(s) 518-525, ISSN 1957-2557 Publisher: Elsevier Masson DOI: 10.1016/j.mmm.2021.05.004 Glucocorticoid Metabolism in Obesity and Following Weight Loss. Author(s): Elina Akalestou; Laurent Genser; Laurent Genser; Guy A. Rutter Published in: Frontiers in Endocrinology, Issue 12, 2020, ISSN 1664-2392 Publisher: Frontiers Media DOI: 10.3389/fendo.2020.00059 A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes Author(s): Marchetti, Piero; Suleiman, Mara; De Luca, Carmela; Baronti, Walter; Bosi, Emanuele; Tesi, Marta; Marselli, Lorella Published in: Seminars in Cell & Developmental Biology, Issue 103, 2021, Page(s) 83-93, ISSN 1084-9521 Publisher: Academic Press DOI: 10.1016/j.semcdb.2020.04.005 Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion Author(s): Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, Amna Khamis, Mickaël Canouil, Philippe Froguel, Anke Schulte, Michele Solimena, Mark Ibberson, Piero Marchetti, Fabian L. Cardenas-Diaz, Paul J. Gadue, Benoit Hastoy, Leonardo Almeida-Souza, Harvey McMahon, Guy A. Rutter Published in: Cell Reports, Issue 34/5, 2021, Page(s) 108703, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2021.108703 Computer simulation models of pre-diabetes populations: a systematic review protocol Author(s): Jose Leal, Waqar Khurshid, Eva Pagano, Talitha Feenstra Published in: BMJ Open, Issue 7/10, 2017, Page(s) e014954, ISSN 2044-6055 Publisher: BMJ Publishing Group DOI: 10.1136/bmjopen-2016-014954 Painting a new picture of personalised medicine for diabetes Author(s): Mark I. McCarthy Published in: Diabetologia, Issue 60/5, 2017, Page(s) 793-799, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-017-4210-x Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy? Author(s): Paul W Franks, Alaitz Poveda Published in: Diabetologia, Issue 60/5, 2017, Page(s) 784-792, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-017-4207-5 HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes Author(s): Roderick C. Slieker, Amber A. W. A. van der Heijden, Nienke van Leeuwen, Hailiang Mei, Giel Nijpels, Joline W. J. Beulens, Leen M. ’t Hart Published in: Diabetologia, Issue 61/1, 2018, Page(s) 138-146, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-017-4467-0 MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells Author(s): Paul Richards, Latif Rachdi, Masaya Oshima, Piero Marchetti, Marco Bugliani, Mathieu Armanet, Catherine Postic, Sandra Guilmeau, Raphael Scharfmann Published in: Diabetes, Issue 67/3, 2018, Page(s) 461-472, ISSN 0012-1797 Publisher: American Diabetes Association DOI: 10.2337/db17-0595 Lifestyle precision medicine: the next generation in type 2 diabetes prevention? Author(s): Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks Published in: BMC Medicine, Issue 15/1, 2017, ISSN 1741-7015 Publisher: BioMed Central DOI: 10.1186/s12916-017-0938-x Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells Author(s): Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea Published in: Molecular Metabolism, Issue 6/9, 2017, Page(s) 1024-1039, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2017.06.001 Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test Author(s): Rohit Babbar, Martin Heni, Andreas Peter, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl, Bernhard Schölkopf, Róbert Wagner Published in: Frontiers in Endocrinology, Issue 9, 2018, ISSN 1664-2392 Publisher: Frontiers Media DOI: 10.3389/fendo.2018.00082 Modeling human pancreatic beta cell dedifferentiation Author(s): Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann Published in: Molecular Metabolism, Issue 10, 2018, Page(s) 74-86, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2018.02.002 Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables Author(s): Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop Published in: The Lancet Diabetes & Endocrinology, Issue 6/5, 2018, Page(s) 361-369, ISSN 2213-8587 Publisher: Elsevier BV DOI: 10.1016/s2213-8587(18)30051-2 Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes Author(s): Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel Published in: Molecular Metabolism, 2019, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2019.03.004 Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes Author(s): Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve Published in: Nucleic Acids Research, Issue 46/19, 2018, Page(s) 10302-10318, ISSN 0305-1048 Publisher: Oxford University Press DOI: 10.1093/nar/gky839 Local and regional control of calcium dynamics in the pancreatic islet Author(s): Guy A. Rutter, David J. Hodson, Pauline Chabosseau, Elizabeth Haythorne, Timothy J. Pullen, Isabelle Leclerc Published in: Diabetes, Obesity and Metabolism, Issue 19, 2017, Page(s) 30-41, ISSN 1462-8902 Publisher: Blackwell Publishing Inc. DOI: 10.1111/dom.12990 The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans Author(s): Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 103/12, 2018, Page(s) 4373-4383, ISSN 0021-972X Publisher: The Endocrine Society DOI: 10.1210/jc.2018-00791 Decision models of prediabetes populations: A systematic review Author(s): Jose Leal, Liam Mc Morrow, Waqar Khurshid, Eva Pagano, Talitha Feenstra Published in: Diabetes, Obesity and Metabolism, 2019, ISSN 1462-8902 Publisher: Blackwell Publishing Inc. DOI: 10.1111/dom.13684 Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes? Author(s): Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop Published in: Current Opinion in Pharmacology, Issue 43, 2018, Page(s) 40-45, ISSN 1471-4892 Publisher: Elsevier BV DOI: 10.1016/j.coph.2018.08.002 The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure Author(s): Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve Published in: Endocrinology, 2019, ISSN 1945-7170 Publisher: Endocrine Society DOI: 10.1210/en.2019-00098 ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor Author(s): Pamela L. Toledo, Juha M. Torkko, Andreas Mueller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora Published in: Journal of Biological Chemistry, 2019, Page(s) 8564-8576, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.ra119.007607 NACHO: a Nanostring nCounter data QC package Author(s): Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen ’t Hart, Roderick Slieker Published in: Bioinformatics, 2019, ISSN 1367-4803 Publisher: Oxford University Press DOI: 10.1093/bioinformatics/btz647 Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo Author(s): Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov, Guy A. Rutter Published in: Nature Metabolism, Issue 1/6, 2019, Page(s) 615-629, ISSN 2522-5812 Publisher: Nature Metabolism DOI: 10.1038/s42255-019-0075-2 Klf6 protects β-cells against insulin resistance-induced dedifferentiation Author(s): Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens Published in: Molecular Metabolism, Issue 35, 2020, Page(s) 100958, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2020.02.001 The supply chain of human pancreatic β cell lines Author(s): Raphael Scharfmann, Willem Staels, Olivier Albagli Published in: Journal of Clinical Investigation, Issue 129/9, 2019, Page(s) 3511-3520, ISSN 0021-9738 Publisher: American Society for Clinical Investigation DOI: 10.1172/jci129484 Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas Author(s): Thomas J. Clough, Nicoleta Baxan, Emma J. Coakley, Charlotte Rivas, Lan Zhao, Isabelle Leclerc, Aida Martinez-Sanchez, Guy A. Rutter, Nicholas J. Long Published in: Dalton Transactions, Issue 49/15, 2020, Page(s) 4732-4740, ISSN 1477-9226 Publisher: Royal Society of Chemistry DOI: 10.1039/d0dt00332h Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity Author(s): Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann Published in: Diabetologia, Issue 63/2, 2020, Page(s) 395-409, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-019-05046-x Fostering improved human islet research: a European perspective Author(s): Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena Published in: Diabetologia, Issue 62/8, 2019, Page(s) 1514-1516, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-019-4911-4 Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine Author(s): Bernard Thorens, Ana Rodriguez, Céline Cruciani-Guglielmacci, Leonore Wigger, Mark Ibberson, Christophe Magnan Published in: Molecular Metabolism, Issue 27, 2019, Page(s) S147-S154, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2019.06.008 The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse Author(s): Blandine Gausserès, Junjun Liu, Ewout Foppen, Cécile Tourrel-Cuzin, Ana Rodriguez Sanchez-Archidona, Etienne Delangre, Céline Cruciani-Guglielmacci, Stéphanie Pons, Uwe Maskos, Bernard Thorens, Christophe Magnan, Jamileh Movassat, Kamel Maouche Published in: Biomolecules, Issue 10/7, 2020, Page(s) 1057, ISSN 2218-273X Publisher: MDPI DOI: 10.3390/biom10071057 Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis Author(s): So, WY; Liu, WN; Teo, AKK; Rutter, GA; Han, W Published in: Science Translational Medicine, 2021, ISSN 1946-6234 Publisher: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.abb1038 The making of insulin in health and disease Author(s): Vasiljević, Jovana; Torkko, Juha M.; Knoch, Klaus-Peter; Solimena, Michele Published in: Diabetologia, Issue 63, 2020, Page(s) 1981-1989, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-020-05192-7 Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells Author(s): C. Berthault, W. Staels, R. Scharfmann Published in: Molecular Metabolism, Issue 42, 2020, Page(s) 101060, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2020.101060 Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion Author(s): Albatoul Zakaria, Claire Berthault, Bertrand Cosson, Vincent Jung, Ida Chiara Guerrera, Latif Rachdi, Raphael Scharfmann Published in: Journal of Biological Chemistry, Issue 297/1, 2021, Page(s) 100839, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1016/j.jbc.2021.100839 Metabolic and functional heterogeneity in pancreatic β cells Author(s): Gabriela da Silva Xavier; Guy A. Rutter Published in: Journal of Molecular Biology, Issue 2, 2020, ISSN 0022-2836 Publisher: Academic Press DOI: 10.1016/j.jmb.2019.08.005 Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study Author(s): Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N. Giordano, Mikael Åkerlund, Mathias J. Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K. Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J. Pullen, Tommi Suvitaival, Asger Wretlind, Pe Published in: Diabetes, 2021, Page(s) db201281, ISSN 0012-1797 Publisher: American Diabetes Association DOI: 10.2337/db20-1281 Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells Author(s): Eleni Georgiadou, Guy A. Rutter Published in: Cell Calcium, Issue 91, 2020, Page(s) 102282, ISSN 0143-4160 Publisher: Churchill Livingstone DOI: 10.1016/j.ceca.2020.102282 Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study Author(s): Slieker, Roderick C.; Donnelly, Louise A.; Fitipaldi, Hugo; Bouland, Gerard A.; Giordano, Giuseppe N.; Åkerlund, Mikael; Gerl, Mathias J.; Ahlqvist, Emma; Ali, Ashfaq; Dragan, Iulian; Festa, Andreas; Hansen, Michael K.; Mansour Aly, Dina; Kim, Min; Kuznetsov, Dmitry; Mehl, Florence; Klose, Christian; Simons, Kai; Pavo, Imre; Pullen, Timothy J.; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter; Published in: Diabetologia, Issue 64, 2021, Page(s) 1982–1989, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-021-05490-8 Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice Author(s): Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Isabelle Leclerc, Guy A. Rutter, Gabriela da Silva Xavier Published in: Diabetologia, Issue 64/1, 2021, Page(s) 129-141, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-020-05292-4 Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research Author(s): Ming Hu, Ines Cherkaoui, Shivani Misra, Guy A. Rutter Published in: Frontiers in Endocrinology, Issue 11, 2020, Page(s) 576-632, ISSN 1664-2392 Publisher: Frontiers in Endocrinology DOI: 10.3389/fendo.2020.576632 Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration Author(s): Hervé Le Stunff, Julien Véret, Nadim Kassis, Jessica Denom, Kelly Meneyrol, Jean-Louis Paul, Céline Cruciani-Guglielmacci, Christophe Magnan, Nathalie Janel Published in: Frontiers in Neurology, Issue 10, 2019, ISSN 1664-2295 Publisher: Frontiers Research Foundation DOI: 10.3389/fneur.2019.00807 Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis Author(s): Cohrs, Christian M.; Panzer, Julia K.; Drotar, Denise M.; Enos, Stephen J.; Kipke, Nicole; Chen, Chunguang; Bozsak, Robert; Schöniger, Eyke; Ehehalt, Florian; Distler, Marius; Brennand, Ana; Bornstein, Stefan R.; Weitz, Jürgen; Solimena, Michele; Speier, Stephan Published in: Cell Reports, Issue 31, 2020, Page(s) 107469, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2020.03.033 Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing Author(s): Seyed M. Ghiasi, Guy A. Rutter Published in: Frontiers in Endocrinology, Issue 12, 2021, ISSN 1664-2392 Publisher: Frontiers DOI: 10.3389/fendo.2021.625235 CONQUER: an interactive toolbox to understand functional consequences of GWAS hits Author(s): Bouland, Gerard A; Beulens, Joline WJ; Nap, Joey; van der Slik, Arno R; Zaldumbide, Arnaud; Hart, Leen M’t; Slieker, Roderick C Published in: NAR Genomics and Bioinformatics, Issue 2, 2020, ISSN 2631-9268 Publisher: Oxford University Press DOI: 10.1093/nargab/lqaa085 Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis Author(s): S. Neda Mousavy Gharavy, Bryn M. Owen, Steven J. Millership, Pauline Chabosseau, Grazia Pizza, Aida Martinez-Sanchez, Emirhan Tasoez, Eleni Georgiadou, Ming Hu, Nicholas H. F. Fine, David A. Jacobson, Matthew T. Dickerson, Olof Idevall-Hagren, Alex Montoya, Holger Kramer, Zenobia Mehta, Dominic J. Withers, Nikolay Ninov, Paul J. Gadue, Fabian L. Cardenas-Diaz, Céline Cruciani-Guglielmacci, Christ Published in: Diabetologia, Issue 64/4, 2021, Page(s) 850-864, ISSN 0012-186X Publisher: Springer Verlag DOI: 10.1007/s00125-020-05350-x Other (1) Manipulation and Measurement of AMPK activity in pancreatic islets Author(s): Aida Martinez-Sanchez, Marie-Sophie Nguyen-Tu, Isabelle Leclerc, Guy A. Rutter Published in: 2017, Page(s) 413-431 Publisher: Springer New York DOI: 10.1007/978-1-4939-7598-3_26 Non-peer reviewed articles (2) The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis Author(s): Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J.Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Published in: Molecular Metabolism, Issue 40, 2020, Page(s) 101015, ISSN 2212-8778 Publisher: Elsevier GmbH DOI: 10.1016/j.molmet.2020.101015 Covid-19 and Diabetes: A Complex Bidirectional Relationship Author(s): Muniangi-Muhitu, Hermine; Akalestou, Elina; Salem, Victoria; Misra, Shivani; Oliver, Nicholas S.; Rutter, Guy A. Published in: Frontiers in Endocrinology, Issue 11, 2020, Page(s) 582936, ISSN 1664-2392 Publisher: Frontiers Media SA DOI: 10.3389/fendo.2020.582936 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
