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Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881

Deliverables

Publications

Prediction of mortality and major cardiovascular complications in type 2 diabetes: External validation of UK Prospective Diabetes Study outcomes model version 2 in two European observational cohorts

Author(s): Eva Pagano, Stefan R. A. Konings, Daniela Di Cuonzo, Rosalba Rosato, Graziella Bruno, Amber A. Heijden, Joline Beulens, Roderick Slieker, Jose Leal, Talitha L. Feenstra
Published in: Diabetes, Obesity and Metabolism, 2021, ISSN 1462-8902
DOI: 10.1111/dom.14311

Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

Author(s): Latif Rachdi, Alicia Maugein, Severine Pechberty, Mathieu Armanet, Juliette Hamroune, Philippe Ravassard, Stefano Marullo, Olivier Albagli, Raphael Scharfmann
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-69758-6

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

Author(s): Chloé Amouyal, Julien Castel, Claudiane Guay, Amélie Lacombe, Jessica Denom, Stéphanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides, Serge Luquet, Hervé Le Stunff, Raphael Scharfmann, Karine Clément, Guy A. Rutter, Olivier Taboureau, Christophe Magnan, Romano Regazzi, Fabrizio Andreelli
Published in: EBioMedicine, Issue 58, 2020, Page(s) 102895, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2020.102895

Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes

Author(s): Marko Barovic, Marius Distler, Eyke Schöniger, Nicole Radisch, Daniela Aust, Jürgen Weitz, Mark Ibberson, Anke M. Schulte, Michele Solimena
Published in: Molecular Metabolism, Issue 27, 2019, Page(s) S1-S6, ISSN 2212-8778
DOI: 10.1016/j.molmet.2019.06.006

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

Author(s): Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Published in: Molecular Metabolism, Issue 37, 2020, Page(s) 100991, ISSN 2212-8778
DOI: 10.1016/j.molmet.2020.100991

Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort

Author(s): Roderick C. Slieker, Amber A. W. H. van der Heijden, Giel Nijpels, Petra J. M. Elders, Leen M. ’t Hart, Joline W. J. Beulens
Published in: Cardiovascular Diabetology, Issue 18/1, 2019, ISSN 1475-2840
DOI: 10.1186/s12933-019-0975-1

Computer simulation models of pre-diabetes populations: a systematic review protocol

Author(s): Jose Leal, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Published in: BMJ Open, Issue 7/10, 2017, Page(s) e014954, ISSN 2044-6055
DOI: 10.1136/bmjopen-2016-014954

Painting a new picture of personalised medicine for diabetes

Author(s): Mark I. McCarthy
Published in: Diabetologia, Issue 60/5, 2017, Page(s) 793-799, ISSN 0012-186X
DOI: 10.1007/s00125-017-4210-x

Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?

Author(s): Paul W Franks, Alaitz Poveda
Published in: Diabetologia, Issue 60/5, 2017, Page(s) 784-792, ISSN 0012-186X
DOI: 10.1007/s00125-017-4207-5

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes

Author(s): Roderick C. Slieker, Amber A. W. A. van der Heijden, Nienke van Leeuwen, Hailiang Mei, Giel Nijpels, Joline W. J. Beulens, Leen M. ’t Hart
Published in: Diabetologia, Issue 61/1, 2018, Page(s) 138-146, ISSN 0012-186X
DOI: 10.1007/s00125-017-4467-0

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells

Author(s): Paul Richards, Latif Rachdi, Masaya Oshima, Piero Marchetti, Marco Bugliani, Mathieu Armanet, Catherine Postic, Sandra Guilmeau, Raphael Scharfmann
Published in: Diabetes, Issue 67/3, 2018, Page(s) 461-472, ISSN 0012-1797
DOI: 10.2337/db17-0595

Lifestyle precision medicine: the next generation in type 2 diabetes prevention?

Author(s): Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks
Published in: BMC Medicine, Issue 15/1, 2017, ISSN 1741-7015
DOI: 10.1186/s12916-017-0938-x

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Author(s): Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Published in: Molecular Metabolism, Issue 6/9, 2017, Page(s) 1024-1039, ISSN 2212-8778
DOI: 10.1016/j.molmet.2017.06.001

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test

Author(s): Rohit Babbar, Martin Heni, Andreas Peter, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl, Bernhard Schölkopf, Róbert Wagner
Published in: Frontiers in Endocrinology, Issue 9, 2018, ISSN 1664-2392
DOI: 10.3389/fendo.2018.00082

Modeling human pancreatic beta cell dedifferentiation

Author(s): Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
Published in: Molecular Metabolism, Issue 10, 2018, Page(s) 74-86, ISSN 2212-8778
DOI: 10.1016/j.molmet.2018.02.002

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Author(s): Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
Published in: The Lancet Diabetes & Endocrinology, Issue 6/5, 2018, Page(s) 361-369, ISSN 2213-8587
DOI: 10.1016/s2213-8587(18)30051-2

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Author(s): Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Published in: Molecular Metabolism, 2019, ISSN 2212-8778
DOI: 10.1016/j.molmet.2019.03.004

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Author(s): Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Published in: Nucleic Acids Research, Issue 46/19, 2018, Page(s) 10302-10318, ISSN 0305-1048
DOI: 10.1093/nar/gky839

Local and regional control of calcium dynamics in the pancreatic islet

Author(s): Guy A. Rutter, David J. Hodson, Pauline Chabosseau, Elizabeth Haythorne, Timothy J. Pullen, Isabelle Leclerc
Published in: Diabetes, Obesity and Metabolism, Issue 19, 2017, Page(s) 30-41, ISSN 1462-8902
DOI: 10.1111/dom.12990

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans

Author(s): Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 103/12, 2018, Page(s) 4373-4383, ISSN 0021-972X
DOI: 10.1210/jc.2018-00791

Decision models of prediabetes populations: A systematic review

Author(s): Jose Leal, Liam Mc Morrow, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Published in: Diabetes, Obesity and Metabolism, 2019, ISSN 1462-8902
DOI: 10.1111/dom.13684

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Author(s): Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Published in: Current Opinion in Pharmacology, Issue 43, 2018, Page(s) 40-45, ISSN 1471-4892
DOI: 10.1016/j.coph.2018.08.002

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure

Author(s): Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
Published in: Endocrinology, 2019, ISSN 1945-7170
DOI: 10.1210/en.2019-00098

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor

Author(s): Pamela L. Toledo, Juha M. Torkko, Andreas Mueller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Published in: bioRxiv, 2019, Page(s) 521351, ISSN 0021-9258
DOI: 10.1101/521351

NACHO: a Nanostring nCounter data QC package

Author(s): Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen ’t Hart, Roderick Slieker
Published in: Bioinformatics, 2019, ISSN 1367-4803
DOI: 10.1093/bioinformatics/btz647

Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo

Author(s): Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov, Guy A. Rutter
Published in: Nature Metabolism, Issue 1/6, 2019, Page(s) 615-629, ISSN 2522-5812
DOI: 10.1038/s42255-019-0075-2

Klf6 protects β-cells against insulin resistance-induced dedifferentiation

Author(s): Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens
Published in: Molecular Metabolism, Issue 35, 2020, Page(s) 100958, ISSN 2212-8778
DOI: 10.1016/j.molmet.2020.02.001

The supply chain of human pancreatic β cell lines

Author(s): Raphael Scharfmann, Willem Staels, Olivier Albagli
Published in: Journal of Clinical Investigation, Issue 129/9, 2019, Page(s) 3511-3520, ISSN 0021-9738
DOI: 10.1172/jci129484

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas

Author(s): Thomas J. Clough, Nicoleta Baxan, Emma J. Coakley, Charlotte Rivas, Lan Zhao, Isabelle Leclerc, Aida Martinez-Sanchez, Guy A. Rutter, Nicholas J. Long
Published in: Dalton Transactions, Issue 49/15, 2020, Page(s) 4732-4740, ISSN 1477-9226
DOI: 10.1039/d0dt00332h

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

Author(s): Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Published in: Diabetologia, Issue 63/2, 2020, Page(s) 395-409, ISSN 0012-186X
DOI: 10.1007/s00125-019-05046-x

Fostering improved human islet research: a European perspective

Author(s): Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
Published in: Diabetologia, Issue 62/8, 2019, Page(s) 1514-1516, ISSN 0012-186X
DOI: 10.1007/s00125-019-4911-4

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine

Author(s): Bernard Thorens, Ana Rodriguez, Céline Cruciani-Guglielmacci, Leonore Wigger, Mark Ibberson, Christophe Magnan
Published in: Molecular Metabolism, Issue 27, 2019, Page(s) S147-S154, ISSN 2212-8778
DOI: 10.1016/j.molmet.2019.06.008

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse

Author(s): Blandine Gausserès, Junjun Liu, Ewout Foppen, Cécile Tourrel-Cuzin, Ana Rodriguez Sanchez-Archidona, Etienne Delangre, Céline Cruciani-Guglielmacci, Stéphanie Pons, Uwe Maskos, Bernard Thorens, Christophe Magnan, Jamileh Movassat, Kamel Maouche
Published in: Biomolecules, Issue 10/7, 2020, Page(s) 1057, ISSN 2218-273X
DOI: 10.3390/biom10071057

Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells

Author(s): Eleni Georgiadou, Guy A. Rutter
Published in: Cell Calcium, Issue 91, 2020, Page(s) 102282, ISSN 0143-4160
DOI: 10.1016/j.ceca.2020.102282

Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice

Author(s): Marie-Sophie Nguyen-Tu, Aida Martinez-Sanchez, Isabelle Leclerc, Guy A. Rutter, Gabriela da Silva Xavier
Published in: Diabetologia, Issue 64/1, 2021, Page(s) 129-141, ISSN 0012-186X
DOI: 10.1007/s00125-020-05292-4

Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research

Author(s): Ming Hu, Ines Cherkaoui, Shivani Misra, Guy A. Rutter
Published in: Frontiers in Endocrinology, Issue 11, 2020, Page(s) 576-632, ISSN 1664-2392
DOI: 10.3389/fendo.2020.576632

Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration

Author(s): Hervé Le Stunff, Julien Véret, Nadim Kassis, Jessica Denom, Kelly Meneyrol, Jean-Louis Paul, Céline Cruciani-Guglielmacci, Christophe Magnan, Nathalie Janel
Published in: Frontiers in Neurology, Issue 10, 2019, ISSN 1664-2295
DOI: 10.3389/fneur.2019.00807

Manipulation and Measurement of AMPK activity in pancreatic islets

Author(s): Aida Martinez-Sanchez, Marie-Sophie Nguyen-Tu, Isabelle Leclerc, Guy A. Rutter
Published in: 2017, Page(s) 413-431
DOI: 10.1007/978-1-4939-7598-3_26

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Author(s): Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J.Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien
Published in: 2020
DOI: 10.1101/2020.03.25.007286

Datasets

Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes"

Author(s): Wigger, Leonore; Barovic, Marko; Brunner, Andreas-David; Marzetta, Flavia; Schöniger, Eyke; Mehl, Florence; Kipke, Nicole; Friedland, Daniela; Burdet, Frederic; Kessler, Camille; Lesche, Mathias; Thorens, Bernard; Bonifacio, Ezio; Legido Quigley, Cristina; Barbier Saint Hilaire, Pierre; Delerive, Philippe; Dahl, Andreas; Klose, Christian; Gerl, Mathias J; Simons, Kai; Aust, Daniela; Weitz, Jürgen; Distler, Marius; Schulte, Anke M; Mann, Matthias; Ibberson, Mark; Solimena, Michele
Published in: Zenodo

Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes"

Author(s): Wigger, Leonore; Barovic, Marko; Brunner, Andreas-David; Marzetta, Flavia; Schöniger, Eyke; Mehl, Florence; Kipke, Nicole; Friedland, Daniela; Burdet, Frederic; Kessler, Camille; Lesche, Mathias; Thorens, Bernard; Bonifacio, Ezio; Legido Quigley, Cristina; Barbier Saint Hilaire, Pierre; Delerive, Philippe; Dahl, Andreas; Klose, Christian; Gerl, Mathias J; Simons, Kai; Aust, Daniela; Weitz, Jürgen; Distler, Marius; Schulte, Anke M; Mann, Matthias; Ibberson, Mark; Solimena, Michele
Published in: Zenodo