Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952 | AMYPAD | Project | Results | H2020 | CORDIS

Resultado final

Open-source software suite for quantification of amyloid PET images

Report and demo of an opensource software suite for amyloid PET quantification will be developed to make available to the medical and scientific communities all the methodological developments that will be developed in AMYPAD including dynamic image quantification

Publicaciones

Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease

Autores: Julia Pfeil, Merle C. Hoenig, Elena Doering, Thilo van Eimeren, Alexander Drzezga, Gérard N. Bischof
Publicado en: Neurobiology of Aging, 2021, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2021.06.014

Ethical Frameworks for Disclosure of Alzheimer Disease Biomarkers to Research Participants: Conflicting Norms and a Nuanced Policy

Autores: Eline M. Bunnik, Marthe Smedinga, Richard Milne, Jean Georges, Edo Richard, Maartje H. N. Schermer
Publicado en: Ethics and Human Research, 2022, ISSN 2578-2363
Editor: The Hastings Center
DOI: 10.1002/eahr.500146

NiftyPAD Novel Python package for quantitative analysis of dynamic PET data

Autores: Jieqing Jiao, Fiona Heeman, Rachael Dixon, Catriona Wimberley, Isadora Lopes Alves, Juan Domingo Gispert, Adriaan A. Lammertsma, Bart N. M. van Berckel, Casper da Costa-Luis, Pawel Markiewicz, David M. Cash, M Jorge Cardoso, Sebastién Ourselin, Maqsood Yaqub, Frederik Barkhof
Publicado en: Neuroinformatics, 2023, ISSN 2213-1582
Editor: Elsevier BV
DOI: 10.1007/s12021-022-09616-0

Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults

Autores: Emma S. Luckett, Yasmina Abakkouy, Mariska Reinartz, Katarzyna Adamczuk, Jolien Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen, Rik Vandenberghe
Publicado en: Alzheimer’s Research and Therapy, Edición 15525260, 2022, ISSN 1552-5260
Editor: Elsevier BV
DOI: 10.1186/s13195-022-01079-4

Parametric imaging of dual-time window [18F]flutemetamol and [18F]florbetaben studies

Autores: Fiona Heeman, Maqsood Yaqub, Janine Hendriks, Ilona Bader, Frederik Barkhof, Juan Domingo Gispert, Bart N.M. van Berckel, Isadora Lopes Alves, Adriaan A. Lammertsma
Publicado en: NeuroImage, Edición 234, 2021, Página(s) 117953, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2021.117953

Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias

Autores: Gaël Chételat, Javier Arbizu, Henryk Barthel, Valentina Garibotto, Ian Law, Silvia Morbelli, Elsmarieke van de Giessen, Federica Agosta, Frederik Barkhof, David J Brooks, Maria C Carrillo, Bruno Dubois, Anders M Fjell, Giovanni B Frisoni, Oskar Hansson, Karl Herholz, Brian F Hutton, Clifford R Jack, Adriaan A Lammertsma, Susan M Landau, Satoshi Minoshima, Flavio Nobili, Agneta Nordberg, Rik Osse
Publicado en: The Lancet Neurology, Edición 19/11, 2020, Página(s) 951-962, ISSN 1474-4422
Editor: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(20)30314-8

Regional associations of white matter hyperintensities and early cortical amyloid pathology

Autores: Luigi Lorenzini, Loes T Ansems, Isadora Lopes Alves, Silvia Ingala, David Vállez García, Jori Tomassen, Carole Sudre, Gemma Salvadó, Mahnaz Shekari, Gregory Operto, Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Mara Ten Kate, Betty Tijms, Alle Meije Wink, Henk J M M Mutsaerts, Anouk den Braber, Pieter Jelle Visser, Bart N M van Berckel, Juan Domingo Gispert, Frederik Barkhof, Lyduine E Coll
Publicado en: Brain, Edición 00068950, 2022, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/braincomms/fcac150

[11C]PIB amyloid quantification: effect of reference region selection

Autores: Fiona Heeman, Janine Hendriks, Isadora Lopes Alves, Rik Ossenkoppele, Nelleke Tolboom, Bart N. M. van Berckel, Adriaan A. Lammertsma, Maqsood Yaqub
Publicado en: EJNMMI Research, Edición 10/1, 2020, ISSN 2191-219X
Editor: Springer Berlin
DOI: 10.1186/s13550-020-00714-1

Should doctors offer biomarker testing to those afraid to develop Alzheimer’s dementia? – Applying the method of reflective equilibrium for a clinical dilemma

Autores: Marthe Smedinga, Eline M Bunnik, Edo Richard, Maartje H N Schermer
Publicado en: Journal of bioethical inquiry, Edición 11767529, 2022, ISSN 1176-7529
Editor: University of Otago Press
DOI: 10.1007/s11673-022-10167-x

Spatial-Temporal Patterns of Amyloid-β Accumulation: A Subtype and Stage Inference Model Analysis

Autores: Lyduine E. Collij, Gemma Salvadó, Viktor Wottschel, Sophie E Mastenbroek, Pierre Schoenmakers, Fiona Heeman, Leon Aksman, Alle Meije Wink, Bart N.M. Berckel, Wiesje M van de Flier, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, Sven Haller, Juan Domingo Gispert, Isadora Lopes Alves,.
Publicado en: Neurology, Edición 02134853, 2022, ISSN 0213-4853
Editor: Ediciones Doyma S.A.
DOI: 10.1212/wnl.0000000000200148

Longitudinal pathways of cerebrospinal fluid and positron emission tomography biomarkers of amyloid-β positivity

Autores: Arianna Sala, Agneta Nordberg, Elena Rodriguez-Vieitez
Publicado en: Molecular Psychiatry, 2020, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-020-00950-w

Impact of cereberal blood flow and amyloid load on SUVR Bias

Autores: Fiona Heeman, Maqsood Yaqub, Janine Hendriks, Bart N. M. van Berckel, Lyduine E. Collij, Katherine R. Gray, Richard Manber, Robin Wolz, Valentina Garibotto, Catriona Wimberley, Craig Ritchie, Frederik Barkhof, Juan Domingo Gispert, David Vállez García, Isadora Lopes Alves & Adriaan A. Lammertsma on behalf of the AMYPAD Consortium
Publicado en: European Journal of Nuclear Medicine and Molecular Imaging, Edición 16197070, 2022, ISSN 1619-7070
Editor: Springer Verlag
DOI: 10.1186/s13550-022-00898-8

Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals

Autores: Lyduine E. Collij, Sophie E. Mastenbroek, Gemma Salvadó, Alle Meije Wink, Pieter Jelle Visser, Frederik Barkhof, Bart. N.M. Berckel, Isadora Lopes Alves
Publicado en: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Edición 13/1, 2021, ISSN 2352-8729
Editor: Alzheimer’s and Dementia: Diagnosis, Assessment, and Disease Monitoring
DOI: 10.1002/dad2.12216

Analysis of Psychological Symptoms Following Disclosure of Amyloid–Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline

Autores: Camilla Caprioglio, Federica Ribaldi, Leonie N. C. Visser, Carolina Minguillon, Lyduine E. Collij, Oriol Grau-Rivera, Philip Zeyen, José Luis Molinuevo, Juan Domingo Gispert, Valentina Garibotto, Christian Moro, Zuzana Walker, Paul Edison, Jean-François Demonet, Frederik Barkhof, Philip Scheltens, Isadora Lopes Alves, Rossella Gismondi, Gill Farrar, Andrew W. Stephens, Frank Jessen, Giovanni B.
Publicado en: Jama Network, 2022, ISSN 0098-7484
Editor: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.50921

Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent

Autores: Lyduine E. Collij, Gemma Salvadó, Mahnaz Shekari, Isadora Lopes Alves, Juhan Reimand, Alle Meije Wink, Marissa Zwan, Aida Niñerola-Baizán, Andrés Perissinotti, Philip Scheltens, Milos D. Ikonomovic, Adrian P. L. Smith, Gill Farrar, José Luis Molinuevo, Frederik Barkhof, Christopher J. Buckley, Bart N. M. van Berckel, Juan Domingo Gispert
Publicado en: European Journal of Nuclear Medicine and Molecular Imaging, Edición 48/7, 2021, Página(s) 2169-2182, ISSN 1619-7070
Editor: Springer Verlag
DOI: 10.1007/s00259-020-05174-2

Strategies to reduce sample sizes in Alzheimer’s disease primary and secondary prevention trials using longitudinal amyloid PET imaging

Autores: Isadora Lopes Alves, Fiona Heeman, Lyduine E. Collij, Gemma Salvadó, Nelleke Tolboom, Natàlia Vilor-Tejedor, Pawel Markiewicz, Maqsood Yaqub, David Cash, Elizabeth C. Mormino, Philip S. Insel, Ronald Boellaard, Bart N. M. van Berckel, Adriaan A. Lammertsma, Frederik Barkhof, Juan Domingo Gispert
Publicado en: Alzheimer's Research & Therapy, Edición 13/1, 2021, ISSN 1758-9193
Editor: BioMed Central
DOI: 10.1186/s13195-021-00819-2

Simulating the effect of cerebral blood flow changes on regional quantification of [ 18 F]flutemetamol and [ 18 F]florbetaben studies

Autores: Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Santiago Bullich, Juan D Gispert, Ronald Boellaard, Adriaan A Lammertsma
Publicado en: Journal of Cerebral Blood Flow & Metabolism, 2020, Página(s) 0271678X2091802, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20918029

Description of a European memory clinic cohort undergoing amyloid-PET: the AMYPAD-DPMS

Autores: Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N M van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Léa Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, José Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillón, Karine Fauria, Marta Felez Sanchez, Andreea Rădoi, Alexander D
Publicado en: Alzheimer’s & Dementia, Edición 15525260, 2022, ISSN 1552-5260
Editor: Elsevier BV
DOI: 10.1002/alz.12696

The Framing of “Alzheimer’s Disease”: Differences Between Scientific and Lay Literature and Their Ethical Implications

Autores: Marthe Smedinga, Eline M Bunnik, Edo Richard, Maartje H N Schermer
Publicado en: The Gerontologist, 2020, ISSN 0016-9013
Editor: Gerontological Society of America
DOI: 10.1093/geront/gnaa113

Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The AMYPAD-DPMS Randomized Clinical Trial

Autores: Daniele Altomare, Frederik Barkhof, Camilla Caprioglio.
Publicado en: JAMA Neurology, 2023, ISSN 2168-6149
Editor: American Medical Association
DOI: 10.1001/jamaneurol.2023.0997

Longitudinal changes in 18F-Flutemetamol amyloid load in cognitively intact APOE4 carriers versus noncarriers: Methodological considerations

Autores: Emma S. Luckett, Jolien Schaeverbeke, Steffi De Meyer, Katarzyna Adamczuk, Koen Van Laere, Patrick Dupont, RikVandenberghe
Publicado en: Neuroimage: clinical, 2023, ISSN 2213-1582
Editor: Elsevier BV
DOI: 10.1016/j.nicl.2023.103321

The Amyloid Imaging for the Prevention of Alzheimer's Disease Consortium: A European collaboration with a global impact

Autores: Lyduine Collij; Gill Farrar; David Valléz García; Ilona Bader; Mahnaz Shekari; Luigi Lorenzini; Hugh Pemberton; Daniele Altomare; Sandra Pla; Mery Loor; Pawel Markiewicz; Maqsood Yaqub; Christopher Buckley; Giovanni B. Frisoni; Agneta Nordberg; Pierre Payoux; Andrew Stephens; Rossella Gismondi; Pieter Jelle Visser; Lisa Ford; Mark Schmidt; Cindy Birck; Jean Georges; Anja Mett; Zuzana Walker; Mer
Publicado en: Frontiers in Neurology, 2023, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.1063598

Multitracer model for staging cortical amyloid deposition using PET imaging

Autores: Lyduine E. Collij, Fiona Heeman, Gemma Salvadó, Silvia Ingala, Daniele Altomare, Arno de Wilde, Elles Konijnenberg, Marieke van Buchem, Maqsood Yaqub, Pawel Markiewicz, Sandeep S.V. Golla, Viktor Wottschel, Alle Meije Wink, Pieter Jelle Visser, Charlotte E. Teunissen, Adriaan A. Lammertsma, Philip Scheltens, Wiesje M. van der Flier, Ronald Boellaard, Bart N.M. van Berckel, José Luis Molinuevo, J
Publicado en: Neurology, Edición 95/11, 2020, Página(s) e1538-e1553, ISSN 0028-3878
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010256

Uncertainty analysis of MR-PET image registration for precision neuro-PET imaging

Autores: Pawel J. Markiewicz, Julian C. Matthews, John Ashburner, David M. Cash, David L. Thomas, Enrico De Vita, Anna Barnes, M. Jorge Cardoso, Marc Modat, Richard Brown, Kris Thielemans, Casper da Costa-Luis, Isadora Lopes Alves, Juan Domingo Gispert, Mark E. Schmidt, Paul Marsden, Alexander Hammers, Sebastien Ourselin, Frederik Barkhof
Publicado en: NeuroImage, Edición 232, 2021, Página(s) 117821, ISSN 1053-8119
Editor: Academic Press
DOI: 10.1016/j.neuroimage.2021.117821

NiftyPET: a High-throughput Software Platform for High Quantitative Accuracy and Precision PET Imaging and Analysis

Autores: Pawel J. Markiewicz, Matthias J. Ehrhardt, Kjell Erlandsson, Philip J. Noonan, Anna Barnes, Jonathan M. Schott, David Atkinson, Simon R. Arridge, Brian F. Hutton, Sebastien Ourselin
Publicado en: Neuroinformatics, Edición 16/1, 2018, Página(s) 95-115, ISSN 1539-2791
Editor: Humana Press, Inc.
DOI: 10.1007/s12021-017-9352-y

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Autores: Giovanni B. Frisoni, Frederik Barkhof, Daniele Altomare, Johannes Berkhof, Marina Boccardi, Elisa Canzoneri, Lyduine Collij, Alexander Drzezga, Gill Farrar, Valentina Garibotto, Rossella Gismondi, Juan-Domingo Gispert, Frank Jessen, Miia Kivipelto, Isadora Lopes Alves, José-Luis Molinuevo, Agneta Nordberg, Pierre Payoux, Craig Ritchie, Irina Savicheva, Philip Scheltens, Mark E. Schmidt, Jonathan
Publicado en: Alzheimer's & Dementia, 2018, ISSN 1552-5260
Editor: Elsevier BV
DOI: 10.1016/j.jalz.2018.09.003

Secondary prevention of Alzheimer’s dementia: neuroimaging contributions

Autores: Mara ten Kate, Silvia Ingala, Adam J. Schwarz, Nick C. Fox, Gaël Chételat, Bart N. M. van Berckel, Michael Ewers, Christopher Foley, Juan Domingo Gispert, Derek Hill, Michael C. Irizarry, Adriaan A. Lammertsma, José Luis Molinuevo, Craig Ritchie, Philip Scheltens, Mark E. Schmidt, Pieter Jelle Visser, Adam Waldman, Joanna Wardlaw, Sven Haller, Frederik Barkhof
Publicado en: Alzheimer's Research & Therapy, Edición 10/1, 2018, ISSN 1758-9193
Editor: BioMed Central
DOI: 10.1186/s13195-018-0438-z

Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18 F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods

Autores: Lyduine E. Collij, Elles Konijnenberg, Juhan Reimand, Mara ten Kate, Anouk den Braber, Isadora Lopes Alves, Marissa Zwan, Maqsood Yaqub, Daniëlle M.E. van Assema, Alle Meije Wink, Adriaan A. Lammertsma, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, Bart N.M. van Berckel
Publicado en: Journal of Nuclear Medicine, Edición 60/4, 2019, Página(s) 541-547, ISSN 0161-5505
Editor: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.118.211532

IDEAS becoming reality on the roadmap for biomarker validation in Alzheimer's disease

Autores: Giovanni B Frisoni, Isadora Lopes Alves, Frederik Barkhof
Publicado en: The Lancet Neurology, Edición 18/6, 2019, Página(s) 519-520, ISSN 1474-4422
Editor: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(19)30166-8

Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies

Autores: Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley, Adriaan A. Lammertsma
Publicado en: EJNMMI Research, Edición 9/1, 2019, ISSN 2191-219X
Editor: Springer Berlin
DOI: 10.1186/s13550-019-0499-4

The spatial-temporal ordering of amyloid pathology and opportunities for PET imaging

Autores: Enrico Fantoni, Lyduine Collij, Isadora Lopes Alves, Christopher Buckley, Gill Farrar
Publicado en: Journal of Nuclear Medicine, 2019, Página(s) jnumed.119.235879, ISSN 0161-5505
Editor: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.235879

White matter microstructure disruption in early stage amyloid pathology

Autores: Lyduine E. Collij, Silvia Ingala, Herwin Top, Viktor Wottschel, Kristine E. Stickney, Jori Tomassen, Elles Konijnenberg, Mara ten Kate, Carole Sudre, Isadora Lopes Alves, Maqsood M. Yaqub, Alle Meije Wink, Dennis Van ‘t Ent, Philip Scheltens, Bart N.M. Berckel, Pieter Jelle Visser, Frederik Barkhof, Anouk Den Braber
Publicado en: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Edición 13/1, 2021, ISSN 2352-8729
Editor: Alzheimer's Dement
DOI: 10.1002/dad2.12124

Early detection of amyloid load using 18F-florbetaben PET

Autores: Santiago Bullich, Núria Roé-Vellvé, Marta Marquié, Susan M. Landau, Henryk Barthel, Victor L. Villemagne, Ángela Sanabria, Juan Pablo Tartari, Oscar Sotolongo-Grau, Vincent Doré, Norman Koglin, Andre Müller, Audrey Perrotin, Aleksandar Jovalekic, Susan De Santi, Lluís Tárraga, Andrew W. Stephens, Christopher C. Rowe, Osama Sabri, John P. Seibyl, Mercè Boada
Publicado en: Alzheimer's Research & Therapy, Edición 13/1, 2021, ISSN 1758-9193
Editor: BioMed Central
DOI: 10.1186/s13195-021-00807-6

Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB

Autores: Fiona Heeman, Janine Hendriks, Isadora Lopes Alves, Nelleke Tolboom, Bart N. M. van Berckel, Maqsood Yaqub, Adriaan A. Lammertsma
Publicado en: Molecular Imaging and Biology, Edición 23/3, 2021, Página(s) 335-339, ISSN 1536-1632
Editor: Elsevier BV
DOI: 10.1007/s11307-021-01606-z

Quantification of Amyloid PET for Future Clinical Use: a State-of-the-Art Review

Autores: Hugh G Pemberton, Lyduine E Collij, Fiona Heeman, Ariane Bollack, Mahnaz Shekari, Gemma Salvadó, Isadora Lopes Alves, David Vallez Garcia, Mark Battle, Christopher Buckley, Andrew W Stephens, Santiago Bullich, Valentina Garibotto, Frederik Barkhof, Juan Domingo Gispert, Gill Farrar
Publicado en: European Journal of Nuclear Medicine and Molecular Imaging, Edición 16197070, 2022, ISSN 1619-7070
Editor: Springer Verlag
DOI: 10.1007/s00259-022-05784-y

Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study

Autores: Isadora Lopes Alves, Lyduine E. Collij, Daniele Altomare, Giovanni B. Frisoni, Laure Saint‐Aubert, Pierre Payoux, Miia Kivipelto, Frank Jessen, Alexander Drzezga, Annebet Leeuwis, Alle Meije Wink, Pieter Jelle Visser, Bart N.M. Berckel, Philip Scheltens, Katherine R. Gray, Robin Wolz, Andrew Stephens, Rossella Gismondi, Christopher Buckely, Juan Domingo Gispert, Mark Schmidt, Lisa Ford, Craig Ri
Publicado en: Alzheimer's & Dementia, Edición 16/5, 2020, Página(s) 750-758, ISSN 1552-5260
Editor: Elsevier BV
DOI: 10.1002/alz.12069

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Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952

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