Alzheimers Disease Apolipoprotein Pathology for Treatment Elucidation and Development - Sofia ref.: 115975

Project Information

ADAPTED

Grant agreement ID: 115975

DOI 10.3030/115975

Project closed

EC signature date 9 November 2016

Start date 1 October 2016

End date 30 September 2020

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 6 796 740,00

EU contribution € 3 510 000,00

Coordinated by

FUNDACIO ACE
Spain

Deliverables

Websites, patent fillings, videos etc. (1)

Definition of cognitive composite scores to evaluate rate of disease progression based on cognitive function decline in the ADAPTED cohorts

Migration

Publications

Peer reviewed articles (7)

Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease

Author(s): Shahzad Ahmad, Adelina Orellana, Isabelle Kohler, Lutz Frölich, Itziar de Rojas, Silvia Gil, Mercè Boada, Isabel Hernández, Lucrezia Hausner, Margot H. M. Bakker, Alfredo Cabrera-Socorro, Najaf Amin, Alfredo Ramírez, Agustín Ruiz, Thomas Hankemeier, Cornelia M. Van Duijn
Published in: Alzheimer's Research & Therapy, Issue 12/1, 2020, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-020-00680-9

Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer’s disease

Author(s): M. E. Sáez, A. González-Pérez, B. Hernández-Olasagarre, A. Beà, S. Moreno-Grau, I. de Rojas, G. Monté-Rubio, A. Orellana, S. Valero, J. X. Comella, D. Sanchís, A. Ruiz
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-52724-2

PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

Author(s): Luca Kleineidam, Vincent Chouraki, Tomasz Próchnicki, Sven J. van der Lee, Laura Madrid-Márquez, Holger Wagner-Thelen, Ilker Karaca, Leonie Weinhold, Steffen Wolfsgruber, Anne Boland, Pamela V. Martino Adami, Piotr Lewczuk, Julius Popp, Frederic Brosseron, Iris E. Jansen, Marc Hulsman, Johannes Kornhuber, Oliver Peters, Claudine Berr, Reinhard Heun, Lutz Frölich, Christophe Tzourio, Jean-Franç
Published in: Acta Neuropathologica, Issue 139/6, 2020, Page(s) 1025-1044, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-020-02138-6

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

Author(s): Sven J. van der Lee, Charlotte E. Teunissen, René Pool, Martin J. Shipley, Alexander Teumer, Vincent Chouraki, Debora Melo van Lent, Juho Tynkkynen, Krista Fischer, Jussi Hernesniemi, Toomas Haller, Archana Singh-Manoux, Aswin Verhoeven, Gonneke Willemsen, Francisca A. de Leeuw, Holger Wagner, Jenny van Dongen, Johannes Hertel, Kathrin Budde, Ko Willems van Dijk, Leonie Weinhold, M. Arfan Ikram,
Published in: Alzheimer's & Dementia, 2018, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2017.11.012

Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

Author(s): Michael Peitz, Tamara Bechler, Catrin Cornelia Thiele, Monika Veltel, Melanie Bloschies, Klaus Fliessbach, Alfredo Ramirez, Oliver Brüstle
Published in: Stem Cell Research, Issue 29, 2018, Page(s) 250-253, ISSN 1873-5061
Publisher: Elsevier
DOI: 10.1016/j.scr.2018.04.011

A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport

Author(s): Nienke R. Wevers, Dhanesh G. Kasi, Taylor Gray, Karlijn J. Wilschut, Benjamin Smith, Remko van Vught, Fumitaka Shimizu, Yasuteru Sano, Takashi Kanda, Graham Marsh, Sebastiaan J. Trietsch, Paul Vulto, Henriëtte L. Lanz, Birgit Obermeier
Published in: Fluids and Barriers of the CNS, Issue 15/1, 2018, ISSN 2045-8118
Publisher: BioMed Central
DOI: 10.1186/s12987-018-0108-3

CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers

Author(s): Shahzad Ahmad, Marta del Campo Milan, Oskar Hansson, Ayse Demirkan, Ruiz Agustin, Maria E. Sáez, Nikolaos Giagtzoglou, Alfredo Cabrera-Socorro, Margot H. M. Bakker, Alfredo Ramirez, Thomas Hankemeier, Erik Stomrud, Niklas Mattsson-Carlgren, Philip Scheltens, Wiesje M. van der Flier, M. Arfan Ikram, Anders Malarstig, Charlotte E. Teunissen, Najaf Amin, Cornelia M. van Duijn
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-65038-5