Deliverables
Migration
Knowledge of possible disease mechanisms and targetsMigration
Determination of the cleavage siteMigration
Crystal structure of CD33 generated to ~3 Å and refined to ~2 ÅMigration
Longitudinal, individual two-photon in vivo analysis of microglial Aβ phagocytosis and degradation in the key AD-like mouse lines harboring TREM2 or CD33 alterationsMigration
Knowledge of in vivo microglial activation in MCI/AD with respect to TREM2 genotype and in response to a systemic immune challenge, report on status of posting resultsMigration
Knowledge of phagocytosis and cytokine secretion in human iPSC derived microglia and macrophages linked to TREM2/DC33 mutationsMigration
A comprehensive roadmap for data and knowledge management for the PHAGO consortium, collection of pre-existing ethical documentsMigration
Quantitative microglia Aß uptake measurement using methoxy-X04 administration, microglia isolation and FACS analysis, assessment of microglia proliferation and deathMigration
In vitro analysis of chimeric CD33 and the hCD33 ki mouseMigration
CD33 receptor ligands characterization in human primary monocytesMigration
Knowledge of TREM2/CD33 pathways of patient brain tissue and bloodMigration
Behavioural phenotyping before, at the beginning and after sustained Aβ deposition (3, 6 and 12 month of age of the key AD-like lines harboring TREM2 or CD33 alterationsMigration
Identification of possible biomarkersMigration
map the cleavage sites on TREM2 ectodomains in the presence/absence of the R47H variantMigration
Crystal structure of TREM2 generated to at least 2-3 Å Sanofi, AZMigration
Completion of the analysis of changes in the glycosylation of TREM2 ectodomains in the presence of R47H variantsMigration
Immunohistochemistry / Imaging analysis of key AD-like mouse lines harboring TREM2 or CD33 alterationsMigration
Effect of CD33 ligands or desialylation on respiratory burst, lysosomal acidification, phagocytosis and cytokine releaseMigration
Secretion studies of TREM2 and other shed proteins from iPSC- generated human microglia and macrophagesMigration
Generating APP/PS1 mice with intracerebral Tau injections lacking TREM2, or harbouring human CD33 ki mutation, or lacking CD33Migration
Analyze effect of anti-CD33 antibody in tg4510 and APP/PS1 transgenic miceMigration
Final version of the roadmap for the data and knowledge management for the PHAGO consortiumRoadmap for data and knowledgemanagement with input from all members of the consortium Special emphasis will be invested in the aspect of integrating industry SME and academic data and knowledge management approaches
TREM2/CD33 RNA analyses of human microglial/macrophage populationsMigration
Characterise phagocytosis, activation and neurotoxicity of microglia lacking TREM2 and/or expressing the R47H variant in culture.Migration
Knowledge on cis interaction of CD33 receptor in human phagocytes and on the role of the exact sialic acid type (Neu5Ac vs. Neu5Gc)Migration
Knowledge of TREM2/CD33 signalling (stress) pathways in human iPSC derived microglial/macrophagesMigration
Novel microglial genes associated with AD riskMigration
Knowledge of proteins in MCI/AD CSF with respect to TREM2 and CD33 genotypesMigration
Knowledge of TREM2/CD33 pathways by RNA analyses/whole genome analyses in human microglial/macrophage populationsMigration
Migration
Providing existing and new longitudinal datasets for 2-photon, electrophysiology and behavioural assessments of tg4510 mice and J20 miceMigration
Publications
Author(s):
Jannis Wißfeld, Mona Mathews, Omar Mossad, Paola Picardi, Alessandro Cinti, Loredana Redaelli, Laurent Pradier, Oliver Brüstle & Harald Neumann
Published in:
Scientific Reports, Issue 11, 2021, Page(s) 13462, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-021-92434-2
Author(s):
Angela K. Hodges, Thomas M. Piers, David Collier, Oliver Cousins, Jennifer M. Pocock
Published in:
Neuroimmunology and Neuroinflammation, Issue 2020, 2020, ISSN 2349-6142
Publisher:
OAE Publishing Inc.
DOI:
10.20517/2347-8659.2020.60
Author(s):
Thomas M. Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M. Pocock
Published in:
The FASEB Journal, Issue 34/2, 2020, Page(s) 2436-2450, ISSN 0892-6638
Publisher:
Federation of American Societies for Experimental Biology
DOI:
10.1096/fj.201902447r
Author(s):
Pranav Joshi, Florian Riffel, Sathish Kumar, Nàdia Villacampa, Sandra Theil, Samira Parhizkar, Christian Haass, Marco Colonna, Michael T. Heneka, Thomas Arzberger, Jochen Herms & Jochen Walter
Published in:
Acta Neuropathologica Communications, Issue 9, 2021, Page(s) 168, ISSN 2051-5960
Publisher:
BioMed Central
DOI:
10.1186/s40478-021-01263-x
Author(s):
Pranav Joshi, Florian Riffel, Kanayo Satoh, Masahiro Enomoto, Seema Qamar, Hannah Scheiblich, Nàdia Villacampa, Sathish Kumar, Sandra Theil, Samira Parhizkar, Christian Haass, Michael T. Heneka, Paul E. Fraser, Peter St George-Hyslop, Jochen Walter
Published in:
Glia, Issue 69(12), 2021, Page(s) 2917-2932, ISSN 0894-1491
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/glia.24077
Author(s):
Joseph W. Lewcock, Kai Schlepckow, Gilbert Di Paolo, Sabina Tahirovic, Kathryn M. Monroe, Christian Haass
Published in:
Neuron, Issue 108/5, 2020, Page(s) 801-821, ISSN 0896-6273
Publisher:
Cell Press
DOI:
10.1016/j.neuron.2020.09.029
Author(s):
Nicholas J. Ashton, Marc Suárez-Calvet, Amanda Heslegrave, Abdul Hye, Cristina Razquin, Pau Pastor, Raquel Sanchez-Valle, José L. Molinuevo, Pieter Jelle Visser, Kaj Blennow, Angela K. Hodges, Henrik Zetterberg
Published in:
Alzheimer's Research & Therapy, Issue 11/1, 2019, ISSN 1758-9193
Publisher:
BioMed Central
DOI:
10.1186/s13195-019-0545-5
Author(s):
Melanie Ibach, Mona Mathews, Bettina Linnartz‐Gerlach, Sandra Theil, Sathish Kumar, Regina Feederle, Oliver Brüstle, Harald Neumann, Jochen Walter
Published in:
Glia, Issue 69/5, 2021, Page(s) 1126-1139, ISSN 0894-1491
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23953
Author(s):
Jenny Meinhardt, Josefine Radke, Carsten Dittmayer, Jonas Franz, Carolina Thomas, Ronja Mothes, Michael Laue, Julia Schneider, Sebastian Brünink, Selina Greuel, Malte Lehmann, Olga Hassan, Tom Aschman, Elisa Schumann, Robert Lorenz Chua, Christian Conrad, Roland Eils, Werner Stenzel, Marc Windgassen, Larissa Rößler, Hans-Hilmar Goebel, Hans R. Gelderblom, Hubert Martin, Andreas Nitsche, Walter
Published in:
Nature Neuroscience, Issue 24, 2021, Page(s) 168-175, ISSN 1097-6256
Publisher:
Nature Publishing Group
DOI:
10.1038/s41593-020-00758-5
Author(s):
Claire A. Butler, Alma S. Popescu, Emily J. A. Kitchener, David H. Allendorf, Mar Puigdellívol, Guy C. Brown
Published in:
Journal of Neurochemistry, 2021, ISSN 0022-3042
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/jnc.15327
Author(s):
Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M. Piers, James Staddon, Stephen J. Neame, John Hardy & Jennifer M. Pocock
Published in:
Scientific Reports, 2021, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-021-91207-1
Author(s):
Claire Ann Butler, Peter Thornton, Guy Charles Brown
Published in:
Journal of Neurochemistry, 2021, ISSN 0022-3042
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/jnc.15349
Author(s):
Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti‐Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun‐Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Pao
Published in:
EMBO Molecular Medicine, Issue 12/4, 2020, ISSN 1757-4676
Publisher:
John Wiley & Sons Ltd.
DOI:
10.15252/emmm.201911227
Author(s):
Christine Klaus, Jan N. Hansen, Aurélien Ginolhac, Deborah Gérard, Vinayaga S. Gnanapragassam, Rüdiger Horstkorte, Charlotte Rossdam, Falk F.R. Buettner, Thomas Sauter, Lasse Sinkkonen, Harald Neumann, Bettina Linnartz-Gerlach
Published in:
Neurobiology of Aging, Issue 88, 2020, Page(s) 91-107, ISSN 0197-4580
Publisher:
Elsevier BV
DOI:
10.1016/j.neurobiolaging.2020.01.008
Author(s):
Jannis Wißfeld, Ichiro Nozaki, Mona Mathews, Tamara Raschka, Christian Ebeling, Veit Hornung, Oliver Brüstle, Harald Neumann
Published in:
Glia, Issue 69/6, 2021, Page(s) 1393-1412, ISSN 0894-1491
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23968
Author(s):
David Hans Allendorf, Elske Helena Franssen, Guy Charles Brown
Published in:
Journal of Neurochemistry, Issue 155/4, 2020, Page(s) 403-416, ISSN 0022-3042
Publisher:
Blackwell Publishing Inc.
DOI:
10.1111/jnc.15024
Author(s):
Christine Klaus, Huan Liao, David H. Allendorf, Guy C. Brown, Harald Neumann
Published in:
Glia, Issue 69(7), 2020, Page(s) 1619-1636, ISSN 0894-1491
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23945
Author(s):
Pascale Eede, Juliane Obst, Eileen Benke, Genevieve Yvon‐Durocher, Bernhard C Richard, Niclas Gimber, Jan Schmoranzer, Annett Böddrich, Erich E Wanker, Stefan Prokop, Frank L Heppner
Published in:
EMBO reports, Issue 21/3, 2020, ISSN 1469-221X
Publisher:
Nature Publishing Group
DOI:
10.15252/embr.201948530
Author(s):
Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K. Griffin, Kanayo Satoh, David H. Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel A. Burguillos, Roger B. Dodd, Fusheng Chen, Yalun Zhang, Patrick Flagmeier, Lisa-Maria Needham, Masahiro Enomoto, Seema Qamar, James Henderson, Jochen Walter, Paul E. Fraser, David Klenerman, Steven F. Lee, Peter St George-Hyslop, Guy C. Brown
Published in:
Journal of Biological Chemistry, Issue 296, 2021, Page(s) 100631, ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1016/j.jbc.2021.100631
Author(s):
Anna Mallach, Johan Gobom, Charles Arber, Thomas M. Piers, John Hardy, Selina Wray, Henrik Zetterberg and Jennifer Pocock
Published in:
Cells, Issue 10(11), 2021, Page(s) 2866, ISSN 2073-4409
Publisher:
MDPI
DOI:
10.3390/cells10112866
Author(s):
Huan Liao, Christine Klaus and Harald Neumann
Published in:
International Journal of Molecular Sciences, Issue 21(15), 2020, ISSN 1422-0067
Publisher:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21155494
Author(s):
Parhizkar, Samira; Arzberger, Thomas; Brendel, Matthias; Kleinberger, Gernot; Deussing, Maximilian; Focke, Carola; Nuscher, Brigitte; Xiong, Monica; Ghasemigharagoz, Alireza; Katzmarski, Natalie; Krasemann, Susanne; Lichtenthaler, Stefan F.; Müller, Stephan A.; Colombo, Alessio; Monasor, Laura Sebastian; Tahirovic, Sabina; Herms, Jochen; Willem, Michael; Pettkus, Nadine; Butovsky, Oleg; Bartenste
Published in:
Nature neuroscience, Issue 22, 2019, Page(s) 191-204, ISSN 1097-6256
Publisher:
Nature Publishing Group
DOI:
10.1038/s41593-018-0296-9
Author(s):
Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seema Qamar, Beatriz Gomez Perez‐Nievas, Louise SC Nicol, Susanna Eketjäll, Jefferson Revell, Clare Jones, Andrew Billinton, Peter H St George‐Hyslop, Iain Chessell, Damian C Crowther
Published in:
EMBO Molecular Medicine, Issue 9/10, 2017, Page(s) 1366-1378, ISSN 1757-4676
Publisher:
John Wiley & Sons Ltd.
DOI:
10.15252/emmm.201707673
Author(s):
Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass
Published in:
EMBO Molecular Medicine, Issue 9/10, 2017, Page(s) 1356-1365, ISSN 1757-4676
Publisher:
John Wiley & Sons Ltd.
DOI:
10.15252/emmm.201707672
Author(s):
Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock, Christian Haass
Published in:
Molecular Neurodegeneration, Issue 13/1, 2018, ISSN 1750-1326
Publisher:
BioMed Central
DOI:
10.1186/s13024-018-0280-6
Author(s):
Pablo Garcia-Reitboeck, Alexandra Phillips, Thomas M. Piers, Claudio Villegas-Llerena, Matt Butler, Anna Mallach, Celia Rodrigues, Charles E. Arber, Amanda Heslegrave, Henrik Zetterberg, Harald Neumann, Stephen Neame, Henry Houlden, John Hardy, Jennifer M. Pocock
Published in:
Cell Reports, Issue 24/9, 2018, Page(s) 2300-2311, ISSN 2211-1247
Publisher:
Cell Press
DOI:
10.1016/j.celrep.2018.07.094
Author(s):
Alejandro Carrillo-Jimenez, Mar Puigdellívol, Anna Vilalta, Jose Luis Venero, Guy Charles Brown, Peter StGeorge-Hyslop, Miguel Angel Burguillos
Published in:
Frontiers in Cellular Neuroscience, Issue 12, 2018, ISSN 1662-5102
Publisher:
Frontiers Research Foundation
DOI:
10.3389/fncel.2018.00313
Author(s):
Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva Wozniak, Kristie Wood, Charles A. Mein, Richard J.B. Dobson, David A. Collier, Michael J. O'Neill, Angela K. Hodges, Stephen J. Newhouse
Published in:
Neurobiology of Aging, Issue 69, 2018, Page(s) 151-166, ISSN 0197-4580
Publisher:
Elsevier BV
DOI:
10.1016/j.neurobiolaging.2018.04.019
Author(s):
Phillips AEM, Llerena CV, Piers TM, Cosker K, Hardy J, Pocock JM
Published in:
Journal of Neurology and Neurobiology, Issue 4/3, 2018, ISSN 2379-7150
Publisher:
Sciforschen
DOI:
10.16966/2379-7150.152
Author(s):
Luke A. Miles, Stefan J. Hermans, Gabriela A.N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andrés A. Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C. Hancock, Michael W. Parker
Published in:
iScience, Issue 19, 2019, Page(s) 110-118, ISSN 2589-0042
Publisher:
Cell
DOI:
10.1016/j.isci.2019.07.023
Author(s):
Antonio Boza-Serrano, Rocío Ruiz, Raquel Sanchez-Varo, Juan García-Revilla, Yiyi Yang, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David Allendorf, Jose Carlos Davila, John Stegmayr, Sebastian Jiménez, Maria A. Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine L. Hsieh, Luis M. Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J. Nilsson, Guy C. Bro
Published in:
Acta Neuropathologica, Issue 138/2, 2019, Page(s) 251-273, ISSN 0001-6322
Publisher:
Springer Verlag
DOI:
10.1007/s00401-019-02013-z
Author(s):
Bettina Linnartz‐Gerlach, Liviu‐Gabriel Bodea, Christine Klaus, Aurélien Ginolhac, Rashi Halder, Lasse Sinkkonen, Jochen Walter, Marco Colonna, Harald Neumann
Published in:
Glia, 2018, ISSN 0894-1491
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23563
Author(s):
Johannes Jungverdorben, Andreas Till, Oliver Brüstle
Published in:
Journal of Molecular Medicine, Issue 95/7, 2017, Page(s) 705-718, ISSN 0946-2716
Publisher:
Springer Verlag
DOI:
10.1007/s00109-017-1533-5
Author(s):
Guy C. Brown
Published in:
Journal of Neuroinflammation, Issue 16/1, 2019, ISSN 1742-2094
Publisher:
BioMed Central
DOI:
10.1186/s12974-019-1564-7
Author(s):
Meliha Karsak, Konstantin Glebov, Marina Scheffold, Thomas Bajaj, Amit Kawalia, Ilker Karaca, Sebastian Rading, Johannes Kornhuber, Oliver Peters, Monica Diez‐Fairen, Lutz Frölich, Michael Hüll, Jens Wiltfang, Martin Scherer, Steffi Riedel‐Heller, Anja Schneider, Michael T. Heneka, Klaus Fliessbach, Ahmed Sharaf, Holger Thiele, Martina Lennarz, Frank Jessen, Wolfgang Maier, Christian Kubisch
Published in:
Human Mutation, 2019, ISSN 1059-7794
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/humu.23904
Author(s):
Anna Mallach, Johan Gobom, Henrik Zetterberg, John Hardy, Thomas M Piers, Selina Wray, Jennifer M Pocock
Published in:
Brain Communications, Issue 3/2, 2021, ISSN 2632-1297
Publisher:
Oxford University Press
DOI:
10.1093/braincomms/fcab009
Author(s):
Guy C. Brown and Peter St George-Hyslop
Published in:
Frontiers in Aging Neuroscience, Issue 13, 2022, ISSN 1663-4365
Publisher:
Frontiers Research Foundation
DOI:
10.3389/fnagi.2021.834697
Author(s):
Mar Puigdellívol, David H. Allendorf, Guy C. Brown
Published in:
Frontiers in Cellular Neuroscience, Issue 14, 2020, ISSN 1662-5102
Publisher:
Frontiers Research Foundation
DOI:
10.3389/fncel.2020.00162
Author(s):
David H. Allendorf, Mar Puigdellívol, Guy C. Brown
Published in:
Glia, Issue 68/5, 2020, Page(s) 989-998, ISSN 0894-1491
Publisher:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23757
Author(s):
Shirin Schneeberger, Seung Joon Kim, Pascale Eede, Anastasiya Boltengagen, Caroline Braeuning, Myrto Andreadou, Burkhard Becher, Nikos Karaiskos, Christine Kocks, Nikolaus Rajewsky, Frank L. Heppner
Published in:
bioRxiv, 2021, ISSN 2692-8205
Publisher:
Cold Spring Harbor Laboratory
DOI:
10.1101/2021.04.25.441313
Author(s):
Kiara Freitag, Nele Sterczyk, Julia Schulz, Judith Houtman, Lara Fleck, Stephan J. Sigrist, Frank L. Heppner, Marina Jendrach
Published in:
bioRxiv, 2020, ISSN 2692-8205
Publisher:
Cold Spring Harbor Laboratory
DOI:
10.1101/2020.12.27.424477
Intellectual Property Rights
Application/Publication number:
PCT/
EP2017/068684
Date:
2017-07-24
Application/Publication number:
PCT/
EP2017/068684
Date:
2017-07-24
Application/Publication number:
PCT/
EP2017/068684
Date:
2017-07-24
Application/Publication number:
20
21056037
Date:
2021-03-10
Application/Publication number:
PCT/
EP2017/068684
Date:
2017-07-24
Searching for OpenAIRE data...
There was an error trying to search data from OpenAIRE
No results available