Rezultaty
Migration
Knowledge of possible disease mechanisms and targetsMigration
Determination of the cleavage siteMigration
Crystal structure of CD33 generated to ~3 Å and refined to ~2 ÅMigration
Longitudinal, individual two-photon in vivo analysis of microglial Aβ phagocytosis and degradation in the key AD-like mouse lines harboring TREM2 or CD33 alterationsMigration
Knowledge of in vivo microglial activation in MCI/AD with respect to TREM2 genotype and in response to a systemic immune challenge, report on status of posting resultsMigration
Knowledge of phagocytosis and cytokine secretion in human iPSC derived microglia and macrophages linked to TREM2/DC33 mutationsMigration
A comprehensive roadmap for data and knowledge management for the PHAGO consortium, collection of pre-existing ethical documentsMigration
Quantitative microglia Aß uptake measurement using methoxy-X04 administration, microglia isolation and FACS analysis, assessment of microglia proliferation and deathMigration
In vitro analysis of chimeric CD33 and the hCD33 ki mouseMigration
CD33 receptor ligands characterization in human primary monocytesMigration
Knowledge of TREM2/CD33 pathways of patient brain tissue and bloodMigration
Behavioural phenotyping before, at the beginning and after sustained Aβ deposition (3, 6 and 12 month of age of the key AD-like lines harboring TREM2 or CD33 alterationsMigration
Identification of possible biomarkersMigration
map the cleavage sites on TREM2 ectodomains in the presence/absence of the R47H variantMigration
Crystal structure of TREM2 generated to at least 2-3 Å Sanofi, AZMigration
Completion of the analysis of changes in the glycosylation of TREM2 ectodomains in the presence of R47H variantsMigration
Immunohistochemistry / Imaging analysis of key AD-like mouse lines harboring TREM2 or CD33 alterationsMigration
Effect of CD33 ligands or desialylation on respiratory burst, lysosomal acidification, phagocytosis and cytokine releaseMigration
Secretion studies of TREM2 and other shed proteins from iPSC- generated human microglia and macrophagesMigration
Generating APP/PS1 mice with intracerebral Tau injections lacking TREM2, or harbouring human CD33 ki mutation, or lacking CD33Migration
Analyze effect of anti-CD33 antibody in tg4510 and APP/PS1 transgenic miceMigration
Final version of the roadmap for the data and knowledge management for the PHAGO consortiumRoadmap for data and knowledgemanagement with input from all members of the consortium Special emphasis will be invested in the aspect of integrating industry SME and academic data and knowledge management approaches
TREM2/CD33 RNA analyses of human microglial/macrophage populationsMigration
Characterise phagocytosis, activation and neurotoxicity of microglia lacking TREM2 and/or expressing the R47H variant in culture.Migration
Knowledge on cis interaction of CD33 receptor in human phagocytes and on the role of the exact sialic acid type (Neu5Ac vs. Neu5Gc)Migration
Knowledge of TREM2/CD33 signalling (stress) pathways in human iPSC derived microglial/macrophagesMigration
Novel microglial genes associated with AD riskMigration
Knowledge of proteins in MCI/AD CSF with respect to TREM2 and CD33 genotypesMigration
Knowledge of TREM2/CD33 pathways by RNA analyses/whole genome analyses in human microglial/macrophage populationsMigration
Migration
Providing existing and new longitudinal datasets for 2-photon, electrophysiology and behavioural assessments of tg4510 mice and J20 miceMigration
Publikacje
Autorzy:
Jannis Wißfeld, Mona Mathews, Omar Mossad, Paola Picardi, Alessandro Cinti, Loredana Redaelli, Laurent Pradier, Oliver Brüstle & Harald Neumann
Opublikowane w:
Scientific Reports, Numer 11, 2021, Strona(/y) 13462, ISSN 2045-2322
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41598-021-92434-2
Autorzy:
Angela K. Hodges, Thomas M. Piers, David Collier, Oliver Cousins, Jennifer M. Pocock
Opublikowane w:
Neuroimmunology and Neuroinflammation, Numer 2020, 2020, ISSN 2349-6142
Wydawca:
OAE Publishing Inc.
DOI:
10.20517/2347-8659.2020.60
Autorzy:
Thomas M. Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M. Pocock
Opublikowane w:
The FASEB Journal, Numer 34/2, 2020, Strona(/y) 2436-2450, ISSN 0892-6638
Wydawca:
Federation of American Societies for Experimental Biology
DOI:
10.1096/fj.201902447r
Autorzy:
Pranav Joshi, Florian Riffel, Sathish Kumar, Nàdia Villacampa, Sandra Theil, Samira Parhizkar, Christian Haass, Marco Colonna, Michael T. Heneka, Thomas Arzberger, Jochen Herms & Jochen Walter
Opublikowane w:
Acta Neuropathologica Communications, Numer 9, 2021, Strona(/y) 168, ISSN 2051-5960
Wydawca:
BioMed Central
DOI:
10.1186/s40478-021-01263-x
Autorzy:
Pranav Joshi, Florian Riffel, Kanayo Satoh, Masahiro Enomoto, Seema Qamar, Hannah Scheiblich, Nàdia Villacampa, Sathish Kumar, Sandra Theil, Samira Parhizkar, Christian Haass, Michael T. Heneka, Paul E. Fraser, Peter St George-Hyslop, Jochen Walter
Opublikowane w:
Glia, Numer 69(12), 2021, Strona(/y) 2917-2932, ISSN 0894-1491
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/glia.24077
Autorzy:
Joseph W. Lewcock, Kai Schlepckow, Gilbert Di Paolo, Sabina Tahirovic, Kathryn M. Monroe, Christian Haass
Opublikowane w:
Neuron, Numer 108/5, 2020, Strona(/y) 801-821, ISSN 0896-6273
Wydawca:
Cell Press
DOI:
10.1016/j.neuron.2020.09.029
Autorzy:
Nicholas J. Ashton, Marc Suárez-Calvet, Amanda Heslegrave, Abdul Hye, Cristina Razquin, Pau Pastor, Raquel Sanchez-Valle, José L. Molinuevo, Pieter Jelle Visser, Kaj Blennow, Angela K. Hodges, Henrik Zetterberg
Opublikowane w:
Alzheimer's Research & Therapy, Numer 11/1, 2019, ISSN 1758-9193
Wydawca:
BioMed Central
DOI:
10.1186/s13195-019-0545-5
Autorzy:
Melanie Ibach, Mona Mathews, Bettina Linnartz‐Gerlach, Sandra Theil, Sathish Kumar, Regina Feederle, Oliver Brüstle, Harald Neumann, Jochen Walter
Opublikowane w:
Glia, Numer 69/5, 2021, Strona(/y) 1126-1139, ISSN 0894-1491
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23953
Autorzy:
Jenny Meinhardt, Josefine Radke, Carsten Dittmayer, Jonas Franz, Carolina Thomas, Ronja Mothes, Michael Laue, Julia Schneider, Sebastian Brünink, Selina Greuel, Malte Lehmann, Olga Hassan, Tom Aschman, Elisa Schumann, Robert Lorenz Chua, Christian Conrad, Roland Eils, Werner Stenzel, Marc Windgassen, Larissa Rößler, Hans-Hilmar Goebel, Hans R. Gelderblom, Hubert Martin, Andreas Nitsche, Walter
Opublikowane w:
Nature Neuroscience, Numer 24, 2021, Strona(/y) 168-175, ISSN 1097-6256
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41593-020-00758-5
Autorzy:
Claire A. Butler, Alma S. Popescu, Emily J. A. Kitchener, David H. Allendorf, Mar Puigdellívol, Guy C. Brown
Opublikowane w:
Journal of Neurochemistry, 2021, ISSN 0022-3042
Wydawca:
Blackwell Publishing Inc.
DOI:
10.1111/jnc.15327
Autorzy:
Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M. Piers, James Staddon, Stephen J. Neame, John Hardy & Jennifer M. Pocock
Opublikowane w:
Scientific Reports, 2021, ISSN 2045-2322
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41598-021-91207-1
Autorzy:
Claire Ann Butler, Peter Thornton, Guy Charles Brown
Opublikowane w:
Journal of Neurochemistry, 2021, ISSN 0022-3042
Wydawca:
Blackwell Publishing Inc.
DOI:
10.1111/jnc.15349
Autorzy:
Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti‐Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun‐Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Pao
Opublikowane w:
EMBO Molecular Medicine, Numer 12/4, 2020, ISSN 1757-4676
Wydawca:
John Wiley & Sons Ltd.
DOI:
10.15252/emmm.201911227
Autorzy:
Christine Klaus, Jan N. Hansen, Aurélien Ginolhac, Deborah Gérard, Vinayaga S. Gnanapragassam, Rüdiger Horstkorte, Charlotte Rossdam, Falk F.R. Buettner, Thomas Sauter, Lasse Sinkkonen, Harald Neumann, Bettina Linnartz-Gerlach
Opublikowane w:
Neurobiology of Aging, Numer 88, 2020, Strona(/y) 91-107, ISSN 0197-4580
Wydawca:
Elsevier BV
DOI:
10.1016/j.neurobiolaging.2020.01.008
Autorzy:
Jannis Wißfeld, Ichiro Nozaki, Mona Mathews, Tamara Raschka, Christian Ebeling, Veit Hornung, Oliver Brüstle, Harald Neumann
Opublikowane w:
Glia, Numer 69/6, 2021, Strona(/y) 1393-1412, ISSN 0894-1491
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23968
Autorzy:
David Hans Allendorf, Elske Helena Franssen, Guy Charles Brown
Opublikowane w:
Journal of Neurochemistry, Numer 155/4, 2020, Strona(/y) 403-416, ISSN 0022-3042
Wydawca:
Blackwell Publishing Inc.
DOI:
10.1111/jnc.15024
Autorzy:
Christine Klaus, Huan Liao, David H. Allendorf, Guy C. Brown, Harald Neumann
Opublikowane w:
Glia, Numer 69(7), 2020, Strona(/y) 1619-1636, ISSN 0894-1491
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23945
Autorzy:
Pascale Eede, Juliane Obst, Eileen Benke, Genevieve Yvon‐Durocher, Bernhard C Richard, Niclas Gimber, Jan Schmoranzer, Annett Böddrich, Erich E Wanker, Stefan Prokop, Frank L Heppner
Opublikowane w:
EMBO reports, Numer 21/3, 2020, ISSN 1469-221X
Wydawca:
Nature Publishing Group
DOI:
10.15252/embr.201948530
Autorzy:
Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K. Griffin, Kanayo Satoh, David H. Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel A. Burguillos, Roger B. Dodd, Fusheng Chen, Yalun Zhang, Patrick Flagmeier, Lisa-Maria Needham, Masahiro Enomoto, Seema Qamar, James Henderson, Jochen Walter, Paul E. Fraser, David Klenerman, Steven F. Lee, Peter St George-Hyslop, Guy C. Brown
Opublikowane w:
Journal of Biological Chemistry, Numer 296, 2021, Strona(/y) 100631, ISSN 0021-9258
Wydawca:
American Society for Biochemistry and Molecular Biology Inc.
DOI:
10.1016/j.jbc.2021.100631
Autorzy:
Anna Mallach, Johan Gobom, Charles Arber, Thomas M. Piers, John Hardy, Selina Wray, Henrik Zetterberg and Jennifer Pocock
Opublikowane w:
Cells, Numer 10(11), 2021, Strona(/y) 2866, ISSN 2073-4409
Wydawca:
MDPI
DOI:
10.3390/cells10112866
Autorzy:
Huan Liao, Christine Klaus and Harald Neumann
Opublikowane w:
International Journal of Molecular Sciences, Numer 21(15), 2020, ISSN 1422-0067
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/ijms21155494
Autorzy:
Parhizkar, Samira; Arzberger, Thomas; Brendel, Matthias; Kleinberger, Gernot; Deussing, Maximilian; Focke, Carola; Nuscher, Brigitte; Xiong, Monica; Ghasemigharagoz, Alireza; Katzmarski, Natalie; Krasemann, Susanne; Lichtenthaler, Stefan F.; Müller, Stephan A.; Colombo, Alessio; Monasor, Laura Sebastian; Tahirovic, Sabina; Herms, Jochen; Willem, Michael; Pettkus, Nadine; Butovsky, Oleg; Bartenste
Opublikowane w:
Nature neuroscience, Numer 22, 2019, Strona(/y) 191-204, ISSN 1097-6256
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41593-018-0296-9
Autorzy:
Peter Thornton, Jean Sevalle, Michael J Deery, Graham Fraser, Ye Zhou, Sara Ståhl, Elske H Franssen, Roger B Dodd, Seema Qamar, Beatriz Gomez Perez‐Nievas, Louise SC Nicol, Susanna Eketjäll, Jefferson Revell, Clare Jones, Andrew Billinton, Peter H St George‐Hyslop, Iain Chessell, Damian C Crowther
Opublikowane w:
EMBO Molecular Medicine, Numer 9/10, 2017, Strona(/y) 1366-1378, ISSN 1757-4676
Wydawca:
John Wiley & Sons Ltd.
DOI:
10.15252/emmm.201707673
Autorzy:
Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass
Opublikowane w:
EMBO Molecular Medicine, Numer 9/10, 2017, Strona(/y) 1356-1365, ISSN 1757-4676
Wydawca:
John Wiley & Sons Ltd.
DOI:
10.15252/emmm.201707672
Autorzy:
Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock, Christian Haass
Opublikowane w:
Molecular Neurodegeneration, Numer 13/1, 2018, ISSN 1750-1326
Wydawca:
BioMed Central
DOI:
10.1186/s13024-018-0280-6
Autorzy:
Pablo Garcia-Reitboeck, Alexandra Phillips, Thomas M. Piers, Claudio Villegas-Llerena, Matt Butler, Anna Mallach, Celia Rodrigues, Charles E. Arber, Amanda Heslegrave, Henrik Zetterberg, Harald Neumann, Stephen Neame, Henry Houlden, John Hardy, Jennifer M. Pocock
Opublikowane w:
Cell Reports, Numer 24/9, 2018, Strona(/y) 2300-2311, ISSN 2211-1247
Wydawca:
Cell Press
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10.1016/j.celrep.2018.07.094
Autorzy:
Alejandro Carrillo-Jimenez, Mar Puigdellívol, Anna Vilalta, Jose Luis Venero, Guy Charles Brown, Peter StGeorge-Hyslop, Miguel Angel Burguillos
Opublikowane w:
Frontiers in Cellular Neuroscience, Numer 12, 2018, ISSN 1662-5102
Wydawca:
Frontiers Research Foundation
DOI:
10.3389/fncel.2018.00313
Autorzy:
Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva Wozniak, Kristie Wood, Charles A. Mein, Richard J.B. Dobson, David A. Collier, Michael J. O'Neill, Angela K. Hodges, Stephen J. Newhouse
Opublikowane w:
Neurobiology of Aging, Numer 69, 2018, Strona(/y) 151-166, ISSN 0197-4580
Wydawca:
Elsevier BV
DOI:
10.1016/j.neurobiolaging.2018.04.019
Autorzy:
Phillips AEM, Llerena CV, Piers TM, Cosker K, Hardy J, Pocock JM
Opublikowane w:
Journal of Neurology and Neurobiology, Numer 4/3, 2018, ISSN 2379-7150
Wydawca:
Sciforschen
DOI:
10.16966/2379-7150.152
Autorzy:
Luke A. Miles, Stefan J. Hermans, Gabriela A.N. Crespi, Jonathan H. Gooi, Larissa Doughty, Tracy L. Nero, Jasmina Markulić, Andreas Ebneth, Berthold Wroblowski, Daniel Oehlrich, Andrés A. Trabanco, Marie-Laure Rives, Ines Royaux, Nancy C. Hancock, Michael W. Parker
Opublikowane w:
iScience, Numer 19, 2019, Strona(/y) 110-118, ISSN 2589-0042
Wydawca:
Cell
DOI:
10.1016/j.isci.2019.07.023
Autorzy:
Antonio Boza-Serrano, Rocío Ruiz, Raquel Sanchez-Varo, Juan García-Revilla, Yiyi Yang, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David Allendorf, Jose Carlos Davila, John Stegmayr, Sebastian Jiménez, Maria A. Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine L. Hsieh, Luis M. Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J. Nilsson, Guy C. Bro
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Acta Neuropathologica, Numer 138/2, 2019, Strona(/y) 251-273, ISSN 0001-6322
Wydawca:
Springer Verlag
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10.1007/s00401-019-02013-z
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Bettina Linnartz‐Gerlach, Liviu‐Gabriel Bodea, Christine Klaus, Aurélien Ginolhac, Rashi Halder, Lasse Sinkkonen, Jochen Walter, Marco Colonna, Harald Neumann
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Glia, 2018, ISSN 0894-1491
Wydawca:
John Wiley & Sons Inc.
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10.1002/glia.23563
Autorzy:
Johannes Jungverdorben, Andreas Till, Oliver Brüstle
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Journal of Molecular Medicine, Numer 95/7, 2017, Strona(/y) 705-718, ISSN 0946-2716
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Springer Verlag
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Journal of Neuroinflammation, Numer 16/1, 2019, ISSN 1742-2094
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BioMed Central
DOI:
10.1186/s12974-019-1564-7
Autorzy:
Meliha Karsak, Konstantin Glebov, Marina Scheffold, Thomas Bajaj, Amit Kawalia, Ilker Karaca, Sebastian Rading, Johannes Kornhuber, Oliver Peters, Monica Diez‐Fairen, Lutz Frölich, Michael Hüll, Jens Wiltfang, Martin Scherer, Steffi Riedel‐Heller, Anja Schneider, Michael T. Heneka, Klaus Fliessbach, Ahmed Sharaf, Holger Thiele, Martina Lennarz, Frank Jessen, Wolfgang Maier, Christian Kubisch
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Human Mutation, 2019, ISSN 1059-7794
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John Wiley & Sons Inc.
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10.1002/humu.23904
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Anna Mallach, Johan Gobom, Henrik Zetterberg, John Hardy, Thomas M Piers, Selina Wray, Jennifer M Pocock
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Brain Communications, Numer 3/2, 2021, ISSN 2632-1297
Wydawca:
Oxford University Press
DOI:
10.1093/braincomms/fcab009
Autorzy:
Guy C. Brown and Peter St George-Hyslop
Opublikowane w:
Frontiers in Aging Neuroscience, Numer 13, 2022, ISSN 1663-4365
Wydawca:
Frontiers Research Foundation
DOI:
10.3389/fnagi.2021.834697
Autorzy:
Mar Puigdellívol, David H. Allendorf, Guy C. Brown
Opublikowane w:
Frontiers in Cellular Neuroscience, Numer 14, 2020, ISSN 1662-5102
Wydawca:
Frontiers Research Foundation
DOI:
10.3389/fncel.2020.00162
Autorzy:
David H. Allendorf, Mar Puigdellívol, Guy C. Brown
Opublikowane w:
Glia, Numer 68/5, 2020, Strona(/y) 989-998, ISSN 0894-1491
Wydawca:
John Wiley & Sons Inc.
DOI:
10.1002/glia.23757
Autorzy:
Shirin Schneeberger, Seung Joon Kim, Pascale Eede, Anastasiya Boltengagen, Caroline Braeuning, Myrto Andreadou, Burkhard Becher, Nikos Karaiskos, Christine Kocks, Nikolaus Rajewsky, Frank L. Heppner
Opublikowane w:
bioRxiv, 2021, ISSN 2692-8205
Wydawca:
Cold Spring Harbor Laboratory
DOI:
10.1101/2021.04.25.441313
Autorzy:
Kiara Freitag, Nele Sterczyk, Julia Schulz, Judith Houtman, Lara Fleck, Stephan J. Sigrist, Frank L. Heppner, Marina Jendrach
Opublikowane w:
bioRxiv, 2020, ISSN 2692-8205
Wydawca:
Cold Spring Harbor Laboratory
DOI:
10.1101/2020.12.27.424477
Prawa własności intelektualnej
Numer wniosku/publikacji:
PCT/
EP2017/068684
Data:
2017-07-24
Numer wniosku/publikacji:
PCT/
EP2017/068684
Data:
2017-07-24
Numer wniosku/publikacji:
PCT/
EP2017/068684
Data:
2017-07-24
Numer wniosku/publikacji:
20
21056037
Data:
2021-03-10
Numer wniosku/publikacji:
PCT/
EP2017/068684
Data:
2017-07-24
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