Inhibiting Misfolded protein PRopagation in Neurodegenerative Diseases - Sofia ref.: 116060 | IMPRiND | Project | Results | H2020 | CORDIS

Deliverables

Exploitation Management Final report

Migration

Press release

Migration

Final dissemination activity on project results

Migration

Final data and management knowledge plan

Migration

Launch of website, Twitter and other dissemination activities

Migration

Final evaluation of Impact Key Performance Indicators

Migration

Symposium on critical pathways of propagation and their relevance to human disease

Migration

Publications

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

Author(s): Antonio Dominguez-Meijide, Eftychia Vasili, Annekatrin König, Maria-Sol Cima-Omori, Alain Ibáñez de Opakua, Andrei Leonov, Sergey Ryazanov, Markus Zweckstetter, Christian Griesinger, Tiago F. Outeiro
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69744-y

Reduced serum immunoglobulin G concentrations in multiple sclerosis: prevalence and association with disease-modifying therapy and disease course

Author(s): Greta Zoehner, Andrei Miclea, Anke Salmen, Nicole Kamber, Lara Diem, Christoph Friedli, Maud Bagnoud, Farhad Ahmadi, Myriam Briner, Nazanin Sédille-Mostafaie, Constantinos Kilidireas, Leonidas Stefanis, Andrew Chan, Robert Hoepner, Maria Eleftheria Evangelopoulos
Published in: Therapeutic Advances in Neurological Disorders, Issue 12, 2019, Page(s) 175628641987834, ISSN 1756-2864
Publisher: Sage Journals
DOI: 10.1177/1756286419878340

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

Author(s): Eliana Nachman, Anne S. Wentink, Karine Madiona, Luc Bousset, Taxiarchis Katsinelos, Kieren Allinson, Harm Kampinga, William A. McEwan, Thomas R. Jahn, Ronald Melki, Axel Mogk, Bernd Bukau, Carmen Nussbaum-Krammer
Published in: Journal of Biological Chemistry, Issue 295/28, 2020, Page(s) 9676-9690, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.013478

Identification of cis-acting determinants mediating the unconventional secretion of tau.

Author(s): Taxiarchis Katsinelos; William A. McEwan; Thomas R. Jahn; Walter Nickel
Published in: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021), Issue 5, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.17863/cam.72263

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

Author(s): Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan
Published in: Acta Neuropathologica Communications, Issue 9/1, 2021, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-021-01141-6

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Author(s): Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C. Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon
Published in: Cell Reports, Issue 34/12, 2021, Page(s) 108895, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.108895

Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson’s Disease

Author(s): Alexis Fenyi, Charles Duyckaerts, Luc Bousset, Heiko Braak, Kelly Del Tredici, Ronald Melki, on behalf of the Brainbank Neuro-CEB Neuropathology Network
Published in: Cells, Issue 10/1, 2021, Page(s) 139, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10010139

The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Author(s): Maud Landureau, Virginie Redeker, Tracy Bellande, Stéphanie Eyquem, Ronald Melki
Published in: Journal of Biological Chemistry, 2021, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100737

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy

Author(s): Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas
Published in: Cells, Issue 9/11, 2020, Page(s) 2371, ISSN 2073-4409
Publisher: Cells
DOI: 10.3390/cells9112371

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Author(s): Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, Ronald Melki
Published in: Biochemical and Biophysical Research Communications, Issue 527/3, 2020, Page(s) 760-769, ISSN 0006-291X
Publisher: Academic Press
DOI: 10.1016/j.bbrc.2020.04.091

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles

Author(s): Stephan A. Kaeser, Lisa M. Häsler, Marius Lambert, Carina Bergmann, Astrid Bottelbergs, Clara Theunis, Marc Mercken & Mathias Jucker
Published in: Acta Neuropathologica, 2021, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-021-02400-5

Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells

Author(s): Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF
Published in: Molecular Neurobiology, 2022, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-021-02713-2

LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies

Author(s): Marc Emmenegger, Elena De Cecco, Marian Hruska-Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa-Vergniory, Andrès Gonzalez-Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Adriano Aguzzi
Published in: EMBO Molecular Medicine, 2021, ISSN 1757-4676
Publisher: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202114745

Novel tau filament fold in corticobasal degeneration

Author(s): Wenjuan Zhang, Airi Tarutani, Kathy L. Newell, Alexey G. Murzin, Tomoyasu Matsubara, Benjamin Falcon, Ruben Vidal, Holly J. Garringer, Yang Shi, Takeshi Ikeuchi, Shigeo Murayama, Bernardino Ghetti, Masato Hasegawa, Michel Goedert & Sjors H. W. Scheres
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2043-0

Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy

Author(s): Franziska Hopfner, Nora Möhn, Britta Eiz-Vesper, Britta Maecker-Kolhoff, Jens Gottlieb, Rainer Blasczyk, Nima Mahmoudi, Kaweh Pars, Ortwin Adams, Martin Stangel, Mike P. Wattjes, Günter Höglinger, Thomas Skripuletz
Published in: Neurol Neuroimmunol Neuroinflamm, 2021, ISSN 2332-7812
Publisher: Neurology - Neuroimmunology Neuroinflammation
DOI: 10.1212/nxi.0000000000001020

Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells

Author(s): Marina Pantazopoulou, Viviana Brembati, Angeliki Kanellidi, Luc Bousset, Ronald Melki, Leonidas Stefanis
Published in: Journal of Neurochemistry, 2020, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15174

Author(s): Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi & François Ichas
Published in: npj Parkinson's Disease, 2022, ISSN 2373-8057
Publisher: Springer Nature
DOI: 10.1038/s41531-021-00264-w

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

Author(s): Yang Shi, Alexey G. Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L. Newell, Ruben Vidal, Holly J. Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H. W. Scheres & Michel Goedert
Published in: Acta Neuropathologica, 2021, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-021-02294-3

Convergent molecular defects underpin diverse neurodegenerative diseases

Author(s): George K Tofaris, Noel J Buckley
Published in: J Neurol Neurosurg Psychiatry, 2018, ISSN 0022-3050
Publisher: BMJ Publishing Group
DOI: 10.1136/jnnp-2017-316988

Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease

Author(s): Veselin Grozdanov,Luc Bousset,Meike Hoffmeister,Corinna Bliederhaeuser,Christoph Meier,Karine Madiona,Laura Pieri,Martin Kiechle,Pamela J. McLean,Jan Kassubek,Christian Behrends,Albert C. Ludolph,Jochen H. Weishaupt,Ronald Melki,Karin M. Danzer
Published in: Ann Neurol, 2019, ISSN 0364-5134
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ana.25557

Les protéinopathies infectieuses de Parkinson et d’Alzheimer

Author(s): R. Melki
Published in: Bulletin de l'Académie Nationale de Médecine, Issue 204/3, 2020, Page(s) 224-231, ISSN 0001-4079
Publisher: Elsevier BV
DOI: 10.1016/j.banm.2019.12.019

Tau in the brain interstitial fluid is fragmented and seeding–competent

Author(s): Erica Barini, Gudrun Plotzky, Yulia Mordashova, Jonas Hoppe, Esther Rodriguez-Correa, Sonja Julier, Florie LePrieult, Ina Mairhofer, Mario Mezler, Sandra Biesinger, Miroslav Cik, Marcus W Meinhardt, Ebru Ercan-Herbst, Dagmar Ehrnhoefer, Andreas Striebinger, Karen Bodie, Corinna Klein, Laura Gasparini, Kerstin Schlegel
Published in: Neurobiology of Aging, 2022, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2021.09.013

Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Author(s): Lindsay McMurray, Jennifer A. Macdonald, Nisha Kuzhuppilly Ramakrishnan, Yanyan Zhao, David W. Williamson, Ole Tietz, Xiaoyun Zhou, Steven Kealey, Steven G. Fagan, Tomáš Smolek, Veronika Cubinkova, Norbert Žilka, Maria Grazia Spillantini, Aviva M. Tolkovsky, Michel Goedert, and Franklin I. Aigbirhio
Published in: ACS Chem. Neurosci., 2021, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.0c00790

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Author(s): Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle, Derya R. Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver
Published in: Molecular Neurodegeneration, Issue 16/1, 2021, ISSN 1750-1326
Publisher: BioMed Central
DOI: 10.1186/s13024-021-00471-2

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

Author(s): George K. Tofaris
Published in: Journal of Parkinson's Disease, Issue 7/4, 2017, Page(s) 569-576, ISSN 1877-7171
Publisher: IOS Press
DOI: 10.3233/JPD-171176

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

Author(s): Franziska Kundel, Liu Hong, Benjamin Falcon, William A. McEwan, Thomas C. T. Michaels, Georg Meisl, Noemi Esteras, Andrey Y. Abramov, Tuomas J. P. Knowles, Michel Goedert, David Klenerman
Published in: ACS Chemical Neuroscience, 2018, ISSN 1948-7193
Publisher: American Chemical Society
DOI: 10.1021/acschemneuro.8b00094

Cryo-EM structures of tau filaments from Alzheimer’s disease

Author(s): Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, R. Anthony Crowther, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Published in: Nature, Issue 547/7662, 2017, Page(s) 185-190, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/nature23002

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Author(s): Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G. Murzin, Ruben Vidal, Holly J. Garringer, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Published in: Acta Neuropathologica, Issue 136/5, 2018, Page(s) 699-708, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-018-1914-z

Tau Filaments and the Development of Positron Emission Tomography Tracers

Author(s): Michel Goedert, Yoshiki Yamaguchi, Sushil K. Mishra, Makoto Higuchi, Naruhiko Sahara
Published in: Frontiers in Neurology, Issue 9, 2018, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00070

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

Author(s): Simona Gribaudo, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier
Published in: Stem Cell Reports, Issue 12/2, 2019, Page(s) 230-244, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2018.12.007

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Author(s): Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Published in: Nature, Issue 561/7721, 2018, Page(s) 137-140, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-018-0454-y

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na + /K + ‐ATPase and AMPA receptors

Author(s): Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhes‐Hamon, Audrey Coens, Luc Buée, Philippe Hantraye, Antoine Triller, Ronald Melki
Published in: The EMBO Journal, Issue 38/3, 2019, Page(s) e99871, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.201899871

Neurodegeneration and the ordered assembly of α-synuclein

Author(s): Maria Grazia Spillantini, Michel Goedert
Published in: Cell and Tissue Research, Issue 373/1, 2018, Page(s) 137-148, ISSN 0302-766X
Publisher: Springer Verlag
DOI: 10.1007/s00441-017-2706-9

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

Author(s): Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeiro
Published in: Frontiers in Molecular Neuroscience, Issue 12, 2019, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2019.00107

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Author(s): Gregor Bieri, Michel Brahic, Luc Bousset, Julien Couthouis, Nicholas J. Kramer, Rosanna Ma, Lisa Nakayama, Marie Monbureau, Erwin Defensor, Birgitt Schüle, Mehrdad Shamloo, Ronald Melki, Aaron D. Gitler
Published in: Acta Neuropathologica, 2019, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-01995-0

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Author(s): Panagiota Mavroeidi, Fedra Arvanitaki, Anastasia-Kiriaki Karakitsou, Maria Vetsi, Ismini Kloukina, Markus Zweckstetter, Karin Giller, Stefan Becker, Zachary A. Sorrentino, Benoit I. Giasson, Poul Henning Jensen, Leonidas Stefanis, Maria Xilouri
Published in: Acta Neuropathologica, 2019, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-019-02014-y

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces

Author(s): Alexis Fenyi, Audrey Coens, Tracy Bellande, Ronald Melki, Luc Bousset
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-28856-2

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Author(s): Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
Published in: Biophysical Journal, 2020, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Author(s): Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-61757-x

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Author(s): Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-019-0859-3

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Author(s): Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen
Published in: Journal of Neurochemistry, Issue 150/5, 2019, Page(s) 522-534, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14808

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Author(s): Alexis Fenyi, Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Ronald Melki, Pascal Derkinderen, Luc Bousset
Published in: Neurobiology of Disease, Issue 129, 2019, Page(s) 38-43, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2019.05.002

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Author(s): Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors HW Scheres
Published in: Elife, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/468892

How is alpha‐synuclein cleared from the cell?

Author(s): Leonidas Stefanis, Evangelia Emmanouilidou, Marina Pantazopoulou, Deniz Kirik, Kostas Vekrellis, George K. Tofaris
Published in: Journal of Neurochemistry, Issue 150/5, 2019, Page(s) 577-590, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14704

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

Author(s): Audrey Chabrat, Emmanuelle Lacassagne, Rodolphe Billiras, Sophie Landron, Amélie Pontisso-Mahout, Hélène Darville, Alain Dupront, Francis Coge, Esther Schenker, David Piwnica, Emmanuel Nivet, François Féron, Clotilde Mannoury la Cour
Published in: Stem Cells International, Issue 2019, 2019, Page(s) 1-15, ISSN 1687-966X
Publisher: Hindawi
DOI: 10.1155/2019/2945435

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

Author(s): Taxiarchis Katsinelos, Benjamin J. Tuck, Aamir S. Mukadam, William A. McEwan
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
Publisher: PMC
DOI: 10.3389/fimmu.2019.01139

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Author(s): Benjamin Falcon, Jasenko Zivanov, Wenjuan Zhang, Alexey G. Murzin, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Kathy L. Newell, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Published in: Nature, Issue 568/7752, 2019, Page(s) 420-423, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-1026-5

Structures of α-synuclein filaments from multiple system atrophy

Author(s): Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G. Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H. W. Scheres, Michel Goedert
Published in: Nature, 2020, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2317-6

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

Author(s): Anke Van der Perren, Géraldine Gelders, Alexis Fenyi, Luc Bousset, Filipa Brito, Wouter Peelaerts, Chris Van den Haute, Steve Gentleman, Ronald Melki, Veerle Baekelandt
Published in: Acta Neuropathologica, Issue 139/6, 2020, Page(s) 977-1000, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-020-02157-3

Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts

Author(s): Margaux Teil, Marie-Laure Arotcarena, Emilie, Faggiani Florent Laferriere, Erwan Bezard, Benjamin Dehay
Published in: Biomolecules, 2022, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom10030391

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Author(s): Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker
Published in: Acta Neuropathologica Communications, Issue 8/1, 2020, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-020-00993-8

Structure-based classification of tauopathies

Author(s): Yang Shi, Wenjuan Zhang, Yang Yang, Alexey G. Murzin, Benjamin Falcon, Abhay Kotecha, Mike van Beers, Airi Tarutani, Fuyuki Kametani, Holly J. Garringer, Ruben Vidal, Grace I. Hallinan, Tammaryn Lashley, Yuko Saito, Shigeo Murayama, Mari Yoshida, Hidetomo Tanaka, Akiyoshi Kakita, Takeshi Ikeuchi, Andrew C. Robinson, David M. A. Mann, Gabor G. Kovacs, Tamas Revesz, Bernardino Ghetti, Masato Hasegaw
Published in: Nature, Issue 598/7880, 2021, Page(s) 359-363, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03911-7

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Author(s): Ruth E. Uhlmann1,2,3,*, Christine Rother1,2,3,*, Jay Rasmussen1,2,3, Juliane Schelle1,2, Carina Bergmann1, Emily M. Ullrich Gavilanes1,3, Sarah K. Fritschi1,2, Anika Buehler1,2, Frank Baumann1,2, Angelos Skodras1,2, Rawaa Al-Shaana1,2, Natalie Beschorner1,2, Lan Ye1,2, Stephan A. Kaeser1,2, Ulrike Obermüller1,2, Søren Christensen4, Fredrik Kartberg4, Jeffrey B. Stavenhagen4, Jens-Ulrich Rahfeld5
Published in: Nature Neuroscience, 2020, ISSN 1546-1726
Publisher: Nature
DOI: 10.5281/zenodo.4562254

Phenotypic manifestation of α-synuclein strainsderived from Parkinson’s disease and multiplesystem atrophy in human dopaminergic neurons

Author(s): Benedict Tanudjojo; Samiha S. Shaikh; Alexis Fenyi; Luc Bousset; Devika Agarwal; Jade Marsh; Christos Zois; Sabrina Heman-Ackah; Roman Fischer; David Sims; Ronald Melki; George K. Tofaris
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23682-z

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons

Author(s): Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
Published in: Science Advances, Issue 6/40, 2020, Page(s) eabc4364, ISSN 2375-2548
Publisher: Science Advances
DOI: 10.1126/sciadv.abc4364

Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy

Author(s): Guerrero-Ferreira, Ricardo; Taylor, Nicholas M..; Arteni, Ana-Andrea; Kumari, Pratibha; Mona, Daniel; Ringler, Philippe; Britschgi, Markus; Lauer, Matthias E.; Makky, Ali; Verasdock, Joeri; Riek, Roland; Melki, Ronald; Meier, Beat H.; Böckmann, Anja; Bousset, Luc; Stahlberg, Henning
Published in: eLife, Issue 2050084X, 2019, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.48907

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Inhibiting Misfolded protein PRopagation in Neurodegenerative Diseases - Sofia ref.: 116060

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