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Inhibiting Misfolded protein PRopagation in Neurodegenerative Diseases - Sofia ref.: 116060

Deliverables

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Publications

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

Author(s): George K. Tofaris
Published in: Journal of Parkinson's Disease, Issue 7/4, 2017, Page(s) 569-576, ISSN 1877-7171
DOI: 10.3233/JPD-171176

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

Author(s): Franziska Kundel, Liu Hong, Benjamin Falcon, William A. McEwan, Thomas C. T. Michaels, Georg Meisl, Noemi Esteras, Andrey Y. Abramov, Tuomas J. P. Knowles, Michel Goedert, David Klenerman
Published in: ACS Chemical Neuroscience, 2018, ISSN 1948-7193
DOI: 10.1021/acschemneuro.8b00094

Cryo-EM structures of tau filaments from Alzheimer’s disease

Author(s): Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, R. Anthony Crowther, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Published in: Nature, Issue 547/7662, 2017, Page(s) 185-190, ISSN 0028-0836
DOI: 10.1038/nature23002

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Author(s): Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G. Murzin, Ruben Vidal, Holly J. Garringer, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Published in: Acta Neuropathologica, Issue 136/5, 2018, Page(s) 699-708, ISSN 0001-6322
DOI: 10.1007/s00401-018-1914-z

Tau Filaments and the Development of Positron Emission Tomography Tracers

Author(s): Michel Goedert, Yoshiki Yamaguchi, Sushil K. Mishra, Makoto Higuchi, Naruhiko Sahara
Published in: Frontiers in Neurology, Issue 9, 2018, ISSN 1664-2295
DOI: 10.3389/fneur.2018.00070

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

Author(s): Simona Gribaudo, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier
Published in: Stem Cell Reports, Issue 12/2, 2019, Page(s) 230-244, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2018.12.007

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Author(s): Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Published in: Nature, Issue 561/7721, 2018, Page(s) 137-140, ISSN 0028-0836
DOI: 10.1038/s41586-018-0454-y

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na + /K + ‐ATPase and AMPA receptors

Author(s): Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhes‐Hamon, Audrey Coens, Luc Buée, Philippe Hantraye, Antoine Triller, Ronald Melki
Published in: The EMBO Journal, Issue 38/3, 2019, Page(s) e99871, ISSN 0261-4189
DOI: 10.15252/embj.201899871

Neurodegeneration and the ordered assembly of α-synuclein

Author(s): Maria Grazia Spillantini, Michel Goedert
Published in: Cell and Tissue Research, Issue 373/1, 2018, Page(s) 137-148, ISSN 0302-766X
DOI: 10.1007/s00441-017-2706-9

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

Author(s): Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeiro
Published in: Frontiers in Molecular Neuroscience, Issue 12, 2019, ISSN 1662-5099
DOI: 10.3389/fnmol.2019.00107

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Author(s): Gregor Bieri, Michel Brahic, Luc Bousset, Julien Couthouis, Nicholas J. Kramer, Rosanna Ma, Lisa Nakayama, Marie Monbureau, Erwin Defensor, Birgitt Schüle, Mehrdad Shamloo, Ronald Melki, Aaron D. Gitler
Published in: Acta Neuropathologica, 2019, ISSN 0001-6322
DOI: 10.1007/s00401-019-01995-0

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Author(s): Panagiota Mavroeidi, Fedra Arvanitaki, Anastasia-Kiriaki Karakitsou, Maria Vetsi, Ismini Kloukina, Markus Zweckstetter, Karin Giller, Stefan Becker, Zachary A. Sorrentino, Benoit I. Giasson, Poul Henning Jensen, Leonidas Stefanis, Maria Xilouri
Published in: Acta Neuropathologica, 2019, ISSN 0001-6322
DOI: 10.1007/s00401-019-02014-y

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces

Author(s): Alexis Fenyi, Audrey Coens, Tracy Bellande, Ronald Melki, Luc Bousset
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
DOI: 10.1038/s41598-018-28856-2

Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons

Author(s): Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
Published in: Nature Comunication, 2020, ISSN 2041-1723
DOI: 10.1101/2020.02.11.943670

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Author(s): Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
Published in: Biophysical Journal, 2020, ISSN 0006-3495
DOI: 10.1016/j.bpj.2020.01.022

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Author(s): Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-61757-x

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Author(s): Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Published in: Acta Neuropathologica Communications, Issue 7/1, 2019, ISSN 2051-5960
DOI: 10.1186/s40478-019-0859-3

Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathy

Author(s): Wenjuan Zhang, Airi Tarutani, Kathy L. Newell, Alexey G. Murzin, Tomoyasu Matsubara, Benjamin Falcon, Ruben Vidal, Holly J. Garringer, Yang Shi, Takeshi Ikeuchi, Shigeo Murayama, Bernardino Ghetti, Masato Hasegawa, Michel Goedert, Sjors H.W. Scheres
Published in: Nature, 2020, ISSN 2041-1723
DOI: 10.1101/811703

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Author(s): Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen
Published in: Journal of Neurochemistry, Issue 150/5, 2019, Page(s) 522-534, ISSN 0022-3042
DOI: 10.1111/jnc.14808

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

Author(s): Guerrero-Ferreira, Ricardo; Taylor, Nicholas MI; Arteni, Ana-Andreea; Kumari, Pratibha; Mona, Daniel; Ringler, Philippe; Britschgi, Markus; Lauer, Matthias E; Makky, Ali; Verasdonck, Joeri; Riek, Roland; Melki, Ronald; Meier, Beat H; Böckmann, Anja; Bousset, Luc; Stahlberg, Henning
Published in: EISSN: 2050-084X, Issue 1, 2019, ISSN 2050-084X
DOI: 10.3929/ethz-b-000391777

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Author(s): Alexis Fenyi, Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Ronald Melki, Pascal Derkinderen, Luc Bousset
Published in: Neurobiology of Disease, Issue 129, 2019, Page(s) 38-43, ISSN 0969-9961
DOI: 10.1016/j.nbd.2019.05.002

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Author(s): Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors HW Scheres
Published in: Elife, 2019, ISSN 2050-084X
DOI: 10.1101/468892

How is alpha‐synuclein cleared from the cell?

Author(s): Leonidas Stefanis, Evangelia Emmanouilidou, Marina Pantazopoulou, Deniz Kirik, Kostas Vekrellis, George K. Tofaris
Published in: Journal of Neurochemistry, Issue 150/5, 2019, Page(s) 577-590, ISSN 0022-3042
DOI: 10.1111/jnc.14704

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

Author(s): Audrey Chabrat, Emmanuelle Lacassagne, Rodolphe Billiras, Sophie Landron, Amélie Pontisso-Mahout, Hélène Darville, Alain Dupront, Francis Coge, Esther Schenker, David Piwnica, Emmanuel Nivet, François Féron, Clotilde Mannoury la Cour
Published in: Stem Cells International, Issue 2019, 2019, Page(s) 1-15, ISSN 1687-966X
DOI: 10.1155/2019/2945435

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

Author(s): Taxiarchis Katsinelos, Benjamin J. Tuck, Aamir S. Mukadam, William A. McEwan
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.01139

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Author(s): Benjamin Falcon, Jasenko Zivanov, Wenjuan Zhang, Alexey G. Murzin, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Kathy L. Newell, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Published in: Nature, Issue 568/7752, 2019, Page(s) 420-423, ISSN 0028-0836
DOI: 10.1038/s41586-019-1026-5

Structures of α-synuclein filaments from multiple system atrophy

Author(s): Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G. Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H. W. Scheres, Michel Goedert
Published in: Nature, 2020, ISSN 0028-0836
DOI: 10.1038/s41586-020-2317-6

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

Author(s): Anke Van der Perren, Géraldine Gelders, Alexis Fenyi, Luc Bousset, Filipa Brito, Wouter Peelaerts, Chris Van den Haute, Steve Gentleman, Ronald Melki, Veerle Baekelandt
Published in: Acta Neuropathologica, Issue 139/6, 2020, Page(s) 977-1000, ISSN 0001-6322
DOI: 10.1007/s00401-020-02157-3

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

Author(s): Antonio Dominguez-Meijide1, Eftychia Vasili, Annekatrin König, Maria-Sol Cima-Omori, Andrei Leonov, Sergey Ryazanov, Markus Zweckstetter, Christian Griesinger, Tiago F. Outeiro
Published in: 2020
DOI: 10.1101/2020.01.27.921643