Inhibiting Misfolded protein PRopagation in Neurodegenerative Diseases - Sofia ref.: 116060 | IMPRiND | Project | Results | H2020 | CORDIS

Rezultaty

Exploitation Management Final report

Migration

Press release

Migration

Final dissemination activity on project results

Migration

Final data and management knowledge plan

Migration

Launch of website, Twitter and other dissemination activities

Migration

Final evaluation of Impact Key Performance Indicators

Migration

Symposium on critical pathways of propagation and their relevance to human disease

Migration

Publikacje

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

Autorzy: Antonio Dominguez-Meijide, Eftychia Vasili, Annekatrin König, Maria-Sol Cima-Omori, Alain Ibáñez de Opakua, Andrei Leonov, Sergey Ryazanov, Markus Zweckstetter, Christian Griesinger, Tiago F. Outeiro
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-69744-y

Reduced serum immunoglobulin G concentrations in multiple sclerosis: prevalence and association with disease-modifying therapy and disease course

Autorzy: Greta Zoehner, Andrei Miclea, Anke Salmen, Nicole Kamber, Lara Diem, Christoph Friedli, Maud Bagnoud, Farhad Ahmadi, Myriam Briner, Nazanin Sédille-Mostafaie, Constantinos Kilidireas, Leonidas Stefanis, Andrew Chan, Robert Hoepner, Maria Eleftheria Evangelopoulos
Opublikowane w: Therapeutic Advances in Neurological Disorders, Numer 12, 2019, Strona(/y) 175628641987834, ISSN 1756-2864
Wydawca: Sage Journals
DOI: 10.1177/1756286419878340

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

Autorzy: Eliana Nachman, Anne S. Wentink, Karine Madiona, Luc Bousset, Taxiarchis Katsinelos, Kieren Allinson, Harm Kampinga, William A. McEwan, Thomas R. Jahn, Ronald Melki, Axel Mogk, Bernd Bukau, Carmen Nussbaum-Krammer
Opublikowane w: Journal of Biological Chemistry, Numer 295/28, 2020, Strona(/y) 9676-9690, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.013478

Identification of cis-acting determinants mediating the unconventional secretion of tau.

Autorzy: Taxiarchis Katsinelos; William A. McEwan; Thomas R. Jahn; Walter Nickel
Opublikowane w: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021), Numer 5, 2021, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.17863/cam.72263

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

Autorzy: Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan
Opublikowane w: Acta Neuropathologica Communications, Numer 9/1, 2021, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-021-01141-6

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Autorzy: Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C. Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon
Opublikowane w: Cell Reports, Numer 34/12, 2021, Strona(/y) 108895, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.108895

Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson’s Disease

Autorzy: Alexis Fenyi, Charles Duyckaerts, Luc Bousset, Heiko Braak, Kelly Del Tredici, Ronald Melki, on behalf of the Brainbank Neuro-CEB Neuropathology Network
Opublikowane w: Cells, Numer 10/1, 2021, Strona(/y) 139, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells10010139

The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Autorzy: Maud Landureau, Virginie Redeker, Tracy Bellande, Stéphanie Eyquem, Ronald Melki
Opublikowane w: Journal of Biological Chemistry, 2021, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100737

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy

Autorzy: Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas
Opublikowane w: Cells, Numer 9/11, 2020, Strona(/y) 2371, ISSN 2073-4409
Wydawca: Cells
DOI: 10.3390/cells9112371

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Autorzy: Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, Ronald Melki
Opublikowane w: Biochemical and Biophysical Research Communications, Numer 527/3, 2020, Strona(/y) 760-769, ISSN 0006-291X
Wydawca: Academic Press
DOI: 10.1016/j.bbrc.2020.04.091

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles

Autorzy: Stephan A. Kaeser, Lisa M. Häsler, Marius Lambert, Carina Bergmann, Astrid Bottelbergs, Clara Theunis, Marc Mercken & Mathias Jucker
Opublikowane w: Acta Neuropathologica, 2021, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-021-02400-5

Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells

Autorzy: Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF
Opublikowane w: Molecular Neurobiology, 2022, ISSN 0893-7648
Wydawca: Humana Press, Inc.
DOI: 10.1007/s12035-021-02713-2

LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies

Autorzy: Marc Emmenegger, Elena De Cecco, Marian Hruska-Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa-Vergniory, Andrès Gonzalez-Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Adriano Aguzzi
Opublikowane w: EMBO Molecular Medicine, 2021, ISSN 1757-4676
Wydawca: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202114745

Novel tau filament fold in corticobasal degeneration

Autorzy: Wenjuan Zhang, Airi Tarutani, Kathy L. Newell, Alexey G. Murzin, Tomoyasu Matsubara, Benjamin Falcon, Ruben Vidal, Holly J. Garringer, Yang Shi, Takeshi Ikeuchi, Shigeo Murayama, Bernardino Ghetti, Masato Hasegawa, Michel Goedert & Sjors H. W. Scheres
Opublikowane w: Nature, 2022, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-020-2043-0

Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy

Autorzy: Franziska Hopfner, Nora Möhn, Britta Eiz-Vesper, Britta Maecker-Kolhoff, Jens Gottlieb, Rainer Blasczyk, Nima Mahmoudi, Kaweh Pars, Ortwin Adams, Martin Stangel, Mike P. Wattjes, Günter Höglinger, Thomas Skripuletz
Opublikowane w: Neurol Neuroimmunol Neuroinflamm, 2021, ISSN 2332-7812
Wydawca: Neurology - Neuroimmunology Neuroinflammation
DOI: 10.1212/nxi.0000000000001020

Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells

Autorzy: Marina Pantazopoulou, Viviana Brembati, Angeliki Kanellidi, Luc Bousset, Ronald Melki, Leonidas Stefanis
Opublikowane w: Journal of Neurochemistry, 2020, ISSN 0022-3042
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15174

Autorzy: Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi & François Ichas
Opublikowane w: npj Parkinson's Disease, 2022, ISSN 2373-8057
Wydawca: Springer Nature
DOI: 10.1038/s41531-021-00264-w

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

Autorzy: Yang Shi, Alexey G. Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L. Newell, Ruben Vidal, Holly J. Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H. W. Scheres & Michel Goedert
Opublikowane w: Acta Neuropathologica, 2021, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-021-02294-3

Convergent molecular defects underpin diverse neurodegenerative diseases

Autorzy: George K Tofaris, Noel J Buckley
Opublikowane w: J Neurol Neurosurg Psychiatry, 2018, ISSN 0022-3050
Wydawca: BMJ Publishing Group
DOI: 10.1136/jnnp-2017-316988

Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease

Autorzy: Veselin Grozdanov,Luc Bousset,Meike Hoffmeister,Corinna Bliederhaeuser,Christoph Meier,Karine Madiona,Laura Pieri,Martin Kiechle,Pamela J. McLean,Jan Kassubek,Christian Behrends,Albert C. Ludolph,Jochen H. Weishaupt,Ronald Melki,Karin M. Danzer
Opublikowane w: Ann Neurol, 2019, ISSN 0364-5134
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/ana.25557

Les protéinopathies infectieuses de Parkinson et d’Alzheimer

Autorzy: R. Melki
Opublikowane w: Bulletin de l'Académie Nationale de Médecine, Numer 204/3, 2020, Strona(/y) 224-231, ISSN 0001-4079
Wydawca: Elsevier BV
DOI: 10.1016/j.banm.2019.12.019

Tau in the brain interstitial fluid is fragmented and seeding–competent

Autorzy: Erica Barini, Gudrun Plotzky, Yulia Mordashova, Jonas Hoppe, Esther Rodriguez-Correa, Sonja Julier, Florie LePrieult, Ina Mairhofer, Mario Mezler, Sandra Biesinger, Miroslav Cik, Marcus W Meinhardt, Ebru Ercan-Herbst, Dagmar Ehrnhoefer, Andreas Striebinger, Karen Bodie, Corinna Klein, Laura Gasparini, Kerstin Schlegel
Opublikowane w: Neurobiology of Aging, 2022, ISSN 0197-4580
Wydawca: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2021.09.013

Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Autorzy: Lindsay McMurray, Jennifer A. Macdonald, Nisha Kuzhuppilly Ramakrishnan, Yanyan Zhao, David W. Williamson, Ole Tietz, Xiaoyun Zhou, Steven Kealey, Steven G. Fagan, Tomáš Smolek, Veronika Cubinkova, Norbert Žilka, Maria Grazia Spillantini, Aviva M. Tolkovsky, Michel Goedert, and Franklin I. Aigbirhio
Opublikowane w: ACS Chem. Neurosci., 2021, ISSN 1948-7193
Wydawca: American Chemical Society
DOI: 10.1021/acschemneuro.0c00790

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Autorzy: Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle, Derya R. Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver
Opublikowane w: Molecular Neurodegeneration, Numer 16/1, 2021, ISSN 1750-1326
Wydawca: BioMed Central
DOI: 10.1186/s13024-021-00471-2

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

Autorzy: George K. Tofaris
Opublikowane w: Journal of Parkinson's Disease, Numer 7/4, 2017, Strona(/y) 569-576, ISSN 1877-7171
Wydawca: IOS Press
DOI: 10.3233/JPD-171176

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

Autorzy: Franziska Kundel, Liu Hong, Benjamin Falcon, William A. McEwan, Thomas C. T. Michaels, Georg Meisl, Noemi Esteras, Andrey Y. Abramov, Tuomas J. P. Knowles, Michel Goedert, David Klenerman
Opublikowane w: ACS Chemical Neuroscience, 2018, ISSN 1948-7193
Wydawca: American Chemical Society
DOI: 10.1021/acschemneuro.8b00094

Cryo-EM structures of tau filaments from Alzheimer’s disease

Autorzy: Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, R. Anthony Crowther, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Opublikowane w: Nature, Numer 547/7662, 2017, Strona(/y) 185-190, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/nature23002

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Autorzy: Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G. Murzin, Ruben Vidal, Holly J. Garringer, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Opublikowane w: Acta Neuropathologica, Numer 136/5, 2018, Strona(/y) 699-708, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-018-1914-z

Tau Filaments and the Development of Positron Emission Tomography Tracers

Autorzy: Michel Goedert, Yoshiki Yamaguchi, Sushil K. Mishra, Makoto Higuchi, Naruhiko Sahara
Opublikowane w: Frontiers in Neurology, Numer 9, 2018, ISSN 1664-2295
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00070

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

Autorzy: Simona Gribaudo, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier
Opublikowane w: Stem Cell Reports, Numer 12/2, 2019, Strona(/y) 230-244, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2018.12.007

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Autorzy: Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Opublikowane w: Nature, Numer 561/7721, 2018, Strona(/y) 137-140, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-018-0454-y

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na + /K + ‐ATPase and AMPA receptors

Autorzy: Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhes‐Hamon, Audrey Coens, Luc Buée, Philippe Hantraye, Antoine Triller, Ronald Melki
Opublikowane w: The EMBO Journal, Numer 38/3, 2019, Strona(/y) e99871, ISSN 0261-4189
Wydawca: Nature Publishing Group
DOI: 10.15252/embj.201899871

Neurodegeneration and the ordered assembly of α-synuclein

Autorzy: Maria Grazia Spillantini, Michel Goedert
Opublikowane w: Cell and Tissue Research, Numer 373/1, 2018, Strona(/y) 137-148, ISSN 0302-766X
Wydawca: Springer Verlag
DOI: 10.1007/s00441-017-2706-9

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

Autorzy: Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeiro
Opublikowane w: Frontiers in Molecular Neuroscience, Numer 12, 2019, ISSN 1662-5099
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnmol.2019.00107

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Autorzy: Gregor Bieri, Michel Brahic, Luc Bousset, Julien Couthouis, Nicholas J. Kramer, Rosanna Ma, Lisa Nakayama, Marie Monbureau, Erwin Defensor, Birgitt Schüle, Mehrdad Shamloo, Ronald Melki, Aaron D. Gitler
Opublikowane w: Acta Neuropathologica, 2019, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-019-01995-0

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Autorzy: Panagiota Mavroeidi, Fedra Arvanitaki, Anastasia-Kiriaki Karakitsou, Maria Vetsi, Ismini Kloukina, Markus Zweckstetter, Karin Giller, Stefan Becker, Zachary A. Sorrentino, Benoit I. Giasson, Poul Henning Jensen, Leonidas Stefanis, Maria Xilouri
Opublikowane w: Acta Neuropathologica, 2019, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-019-02014-y

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces

Autorzy: Alexis Fenyi, Audrey Coens, Tracy Bellande, Ronald Melki, Luc Bousset
Opublikowane w: Scientific Reports, Numer 8/1, 2018, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-018-28856-2

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Autorzy: Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
Opublikowane w: Biophysical Journal, 2020, ISSN 0006-3495
Wydawca: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Autorzy: Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
Opublikowane w: Scientific Reports, Numer 10/1, 2020, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-020-61757-x

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Autorzy: Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Opublikowane w: Acta Neuropathologica Communications, Numer 7/1, 2019, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-019-0859-3

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Autorzy: Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen
Opublikowane w: Journal of Neurochemistry, Numer 150/5, 2019, Strona(/y) 522-534, ISSN 0022-3042
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14808

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Autorzy: Alexis Fenyi, Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Ronald Melki, Pascal Derkinderen, Luc Bousset
Opublikowane w: Neurobiology of Disease, Numer 129, 2019, Strona(/y) 38-43, ISSN 0969-9961
Wydawca: Academic Press
DOI: 10.1016/j.nbd.2019.05.002

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Autorzy: Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors HW Scheres
Opublikowane w: Elife, 2019, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.1101/468892

How is alpha‐synuclein cleared from the cell?

Autorzy: Leonidas Stefanis, Evangelia Emmanouilidou, Marina Pantazopoulou, Deniz Kirik, Kostas Vekrellis, George K. Tofaris
Opublikowane w: Journal of Neurochemistry, Numer 150/5, 2019, Strona(/y) 577-590, ISSN 0022-3042
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14704

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

Autorzy: Audrey Chabrat, Emmanuelle Lacassagne, Rodolphe Billiras, Sophie Landron, Amélie Pontisso-Mahout, Hélène Darville, Alain Dupront, Francis Coge, Esther Schenker, David Piwnica, Emmanuel Nivet, François Féron, Clotilde Mannoury la Cour
Opublikowane w: Stem Cells International, Numer 2019, 2019, Strona(/y) 1-15, ISSN 1687-966X
Wydawca: Hindawi
DOI: 10.1155/2019/2945435

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

Autorzy: Taxiarchis Katsinelos, Benjamin J. Tuck, Aamir S. Mukadam, William A. McEwan
Opublikowane w: Frontiers in Immunology, Numer 10, 2019, ISSN 1664-3224
Wydawca: PMC
DOI: 10.3389/fimmu.2019.01139

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Autorzy: Benjamin Falcon, Jasenko Zivanov, Wenjuan Zhang, Alexey G. Murzin, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Kathy L. Newell, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Opublikowane w: Nature, Numer 568/7752, 2019, Strona(/y) 420-423, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-019-1026-5

Structures of α-synuclein filaments from multiple system atrophy

Autorzy: Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G. Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H. W. Scheres, Michel Goedert
Opublikowane w: Nature, 2020, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-020-2317-6

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

Autorzy: Anke Van der Perren, Géraldine Gelders, Alexis Fenyi, Luc Bousset, Filipa Brito, Wouter Peelaerts, Chris Van den Haute, Steve Gentleman, Ronald Melki, Veerle Baekelandt
Opublikowane w: Acta Neuropathologica, Numer 139/6, 2020, Strona(/y) 977-1000, ISSN 0001-6322
Wydawca: Springer Verlag
DOI: 10.1007/s00401-020-02157-3

Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts

Autorzy: Margaux Teil, Marie-Laure Arotcarena, Emilie, Faggiani Florent Laferriere, Erwan Bezard, Benjamin Dehay
Opublikowane w: Biomolecules, 2022, ISSN 2218-273X
Wydawca: MDPI
DOI: 10.3390/biom10030391

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Autorzy: Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker
Opublikowane w: Acta Neuropathologica Communications, Numer 8/1, 2020, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-020-00993-8

Structure-based classification of tauopathies

Autorzy: Yang Shi, Wenjuan Zhang, Yang Yang, Alexey G. Murzin, Benjamin Falcon, Abhay Kotecha, Mike van Beers, Airi Tarutani, Fuyuki Kametani, Holly J. Garringer, Ruben Vidal, Grace I. Hallinan, Tammaryn Lashley, Yuko Saito, Shigeo Murayama, Mari Yoshida, Hidetomo Tanaka, Akiyoshi Kakita, Takeshi Ikeuchi, Andrew C. Robinson, David M. A. Mann, Gabor G. Kovacs, Tamas Revesz, Bernardino Ghetti, Masato Hasegaw
Opublikowane w: Nature, Numer 598/7880, 2021, Strona(/y) 359-363, ISSN 0028-0836
Wydawca: Nature Publishing Group
DOI: 10.1038/s41586-021-03911-7

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Autorzy: Ruth E. Uhlmann1,2,3,*, Christine Rother1,2,3,*, Jay Rasmussen1,2,3, Juliane Schelle1,2, Carina Bergmann1, Emily M. Ullrich Gavilanes1,3, Sarah K. Fritschi1,2, Anika Buehler1,2, Frank Baumann1,2, Angelos Skodras1,2, Rawaa Al-Shaana1,2, Natalie Beschorner1,2, Lan Ye1,2, Stephan A. Kaeser1,2, Ulrike Obermüller1,2, Søren Christensen4, Fredrik Kartberg4, Jeffrey B. Stavenhagen4, Jens-Ulrich Rahfeld5
Opublikowane w: Nature Neuroscience, 2020, ISSN 1546-1726
Wydawca: Nature
DOI: 10.5281/zenodo.4562254

Phenotypic manifestation of α-synuclein strainsderived from Parkinson’s disease and multiplesystem atrophy in human dopaminergic neurons

Autorzy: Benedict Tanudjojo; Samiha S. Shaikh; Alexis Fenyi; Luc Bousset; Devika Agarwal; Jade Marsh; Christos Zois; Sabrina Heman-Ackah; Roman Fischer; David Sims; Ronald Melki; George K. Tofaris
Opublikowane w: Nature Communications, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23682-z

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons

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DOI: 10.1126/sciadv.abc4364

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