Inhibiting Misfolded protein PRopagation in Neurodegenerative Diseases - Sofia ref.: 116060 | IMPRiND | Project | Results | H2020 | CORDIS

Resultado final

Exploitation Management Final report

Migration

Press release

Migration

Final dissemination activity on project results

Migration

Final data and management knowledge plan

Migration

Launch of website, Twitter and other dissemination activities

Migration

Final evaluation of Impact Key Performance Indicators

Migration

Symposium on critical pathways of propagation and their relevance to human disease

Migration

Publicaciones

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

Autores: Antonio Dominguez-Meijide, Eftychia Vasili, Annekatrin König, Maria-Sol Cima-Omori, Alain Ibáñez de Opakua, Andrei Leonov, Sergey Ryazanov, Markus Zweckstetter, Christian Griesinger, Tiago F. Outeiro
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-69744-y

Reduced serum immunoglobulin G concentrations in multiple sclerosis: prevalence and association with disease-modifying therapy and disease course

Autores: Greta Zoehner, Andrei Miclea, Anke Salmen, Nicole Kamber, Lara Diem, Christoph Friedli, Maud Bagnoud, Farhad Ahmadi, Myriam Briner, Nazanin Sédille-Mostafaie, Constantinos Kilidireas, Leonidas Stefanis, Andrew Chan, Robert Hoepner, Maria Eleftheria Evangelopoulos
Publicado en: Therapeutic Advances in Neurological Disorders, Edición 12, 2019, Página(s) 175628641987834, ISSN 1756-2864
Editor: Sage Journals
DOI: 10.1177/1756286419878340

Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species

Autores: Eliana Nachman, Anne S. Wentink, Karine Madiona, Luc Bousset, Taxiarchis Katsinelos, Kieren Allinson, Harm Kampinga, William A. McEwan, Thomas R. Jahn, Ronald Melki, Axel Mogk, Bernd Bukau, Carmen Nussbaum-Krammer
Publicado en: Journal of Biological Chemistry, Edición 295/28, 2020, Página(s) 9676-9690, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.013478

Identification of cis-acting determinants mediating the unconventional secretion of tau.

Autores: Taxiarchis Katsinelos; William A. McEwan; Thomas R. Jahn; Walter Nickel
Publicado en: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021), Edición 5, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.17863/cam.72263

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

Autores: Lauren V. C. Miller, Aamir S. Mukadam, Claire S. Durrant, Marina J. Vaysburd, Taxiarchis Katsinelos, Benjamin J. Tuck, Sophie Sanford, Olivia Sheppard, Claire Knox, Shi Cheng, Leo C. James, Michael P. Coleman, William A. McEwan
Publicado en: Acta Neuropathologica Communications, Edición 9/1, 2021, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-021-01141-6

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Autores: Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C. Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon
Publicado en: Cell Reports, Edición 34/12, 2021, Página(s) 108895, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.108895

Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson’s Disease

Autores: Alexis Fenyi, Charles Duyckaerts, Luc Bousset, Heiko Braak, Kelly Del Tredici, Ronald Melki, on behalf of the Brainbank Neuro-CEB Neuropathology Network
Publicado en: Cells, Edición 10/1, 2021, Página(s) 139, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells10010139

The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Autores: Maud Landureau, Virginie Redeker, Tracy Bellande, Stéphanie Eyquem, Ronald Melki
Publicado en: Journal of Biological Chemistry, 2021, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100737

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy

Autores: Florent Laferrière, Xin He, Federica Zinghirino, Evelyne Doudnikoff, Emilie Faggiani, Wassilios G. Meissner, Erwan Bezard, Francesca De Giorgi, François Ichas
Publicado en: Cells, Edición 9/11, 2020, Página(s) 2371, ISSN 2073-4409
Editor: Cells
DOI: 10.3390/cells9112371

Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces

Autores: Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset, Tracy Bellande, Ronald Melki
Publicado en: Biochemical and Biophysical Research Communications, Edición 527/3, 2020, Página(s) 760-769, ISSN 0006-291X
Editor: Academic Press
DOI: 10.1016/j.bbrc.2020.04.091

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles

Autores: Stephan A. Kaeser, Lisa M. Häsler, Marius Lambert, Carina Bergmann, Astrid Bottelbergs, Clara Theunis, Marc Mercken & Mathias Jucker
Publicado en: Acta Neuropathologica, 2021, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-021-02400-5

Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells

Autores: Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF
Publicado en: Molecular Neurobiology, 2022, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-021-02713-2

LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies

Autores: Marc Emmenegger, Elena De Cecco, Marian Hruska-Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa-Vergniory, Andrès Gonzalez-Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Adriano Aguzzi
Publicado en: EMBO Molecular Medicine, 2021, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202114745

Novel tau filament fold in corticobasal degeneration

Autores: Wenjuan Zhang, Airi Tarutani, Kathy L. Newell, Alexey G. Murzin, Tomoyasu Matsubara, Benjamin Falcon, Ruben Vidal, Holly J. Garringer, Yang Shi, Takeshi Ikeuchi, Shigeo Murayama, Bernardino Ghetti, Masato Hasegawa, Michel Goedert & Sjors H. W. Scheres
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2043-0

Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy

Autores: Franziska Hopfner, Nora Möhn, Britta Eiz-Vesper, Britta Maecker-Kolhoff, Jens Gottlieb, Rainer Blasczyk, Nima Mahmoudi, Kaweh Pars, Ortwin Adams, Martin Stangel, Mike P. Wattjes, Günter Höglinger, Thomas Skripuletz
Publicado en: Neurol Neuroimmunol Neuroinflamm, 2021, ISSN 2332-7812
Editor: Neurology - Neuroimmunology Neuroinflammation
DOI: 10.1212/nxi.0000000000001020

Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells

Autores: Marina Pantazopoulou, Viviana Brembati, Angeliki Kanellidi, Luc Bousset, Ronald Melki, Leonidas Stefanis
Publicado en: Journal of Neurochemistry, 2020, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15174

Autores: Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi & François Ichas
Publicado en: npj Parkinson's Disease, 2022, ISSN 2373-8057
Editor: Springer Nature
DOI: 10.1038/s41531-021-00264-w

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

Autores: Yang Shi, Alexey G. Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L. Newell, Ruben Vidal, Holly J. Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H. W. Scheres & Michel Goedert
Publicado en: Acta Neuropathologica, 2021, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-021-02294-3

Convergent molecular defects underpin diverse neurodegenerative diseases

Autores: George K Tofaris, Noel J Buckley
Publicado en: J Neurol Neurosurg Psychiatry, 2018, ISSN 0022-3050
Editor: BMJ Publishing Group
DOI: 10.1136/jnnp-2017-316988

Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease

Autores: Veselin Grozdanov,Luc Bousset,Meike Hoffmeister,Corinna Bliederhaeuser,Christoph Meier,Karine Madiona,Laura Pieri,Martin Kiechle,Pamela J. McLean,Jan Kassubek,Christian Behrends,Albert C. Ludolph,Jochen H. Weishaupt,Ronald Melki,Karin M. Danzer
Publicado en: Ann Neurol, 2019, ISSN 0364-5134
Editor: John Wiley & Sons Inc.
DOI: 10.1002/ana.25557

Les protéinopathies infectieuses de Parkinson et d’Alzheimer

Autores: R. Melki
Publicado en: Bulletin de l'Académie Nationale de Médecine, Edición 204/3, 2020, Página(s) 224-231, ISSN 0001-4079
Editor: Elsevier BV
DOI: 10.1016/j.banm.2019.12.019

Tau in the brain interstitial fluid is fragmented and seeding–competent

Autores: Erica Barini, Gudrun Plotzky, Yulia Mordashova, Jonas Hoppe, Esther Rodriguez-Correa, Sonja Julier, Florie LePrieult, Ina Mairhofer, Mario Mezler, Sandra Biesinger, Miroslav Cik, Marcus W Meinhardt, Ebru Ercan-Herbst, Dagmar Ehrnhoefer, Andreas Striebinger, Karen Bodie, Corinna Klein, Laura Gasparini, Kerstin Schlegel
Publicado en: Neurobiology of Aging, 2022, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2021.09.013

Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models

Autores: Lindsay McMurray, Jennifer A. Macdonald, Nisha Kuzhuppilly Ramakrishnan, Yanyan Zhao, David W. Williamson, Ole Tietz, Xiaoyun Zhou, Steven Kealey, Steven G. Fagan, Tomáš Smolek, Veronika Cubinkova, Norbert Žilka, Maria Grazia Spillantini, Aviva M. Tolkovsky, Michel Goedert, and Franklin I. Aigbirhio
Publicado en: ACS Chem. Neurosci., 2021, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.0c00790

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Autores: Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle, Derya R. Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver
Publicado en: Molecular Neurodegeneration, Edición 16/1, 2021, ISSN 1750-1326
Editor: BioMed Central
DOI: 10.1186/s13024-021-00471-2

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease

Autores: George K. Tofaris
Publicado en: Journal of Parkinson's Disease, Edición 7/4, 2017, Página(s) 569-576, ISSN 1877-7171
Editor: IOS Press
DOI: 10.3233/JPD-171176

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

Autores: Franziska Kundel, Liu Hong, Benjamin Falcon, William A. McEwan, Thomas C. T. Michaels, Georg Meisl, Noemi Esteras, Andrey Y. Abramov, Tuomas J. P. Knowles, Michel Goedert, David Klenerman
Publicado en: ACS Chemical Neuroscience, 2018, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.8b00094

Cryo-EM structures of tau filaments from Alzheimer’s disease

Autores: Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, R. Anthony Crowther, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Publicado en: Nature, Edición 547/7662, 2017, Página(s) 185-190, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/nature23002

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

Autores: Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G. Murzin, Ruben Vidal, Holly J. Garringer, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Publicado en: Acta Neuropathologica, Edición 136/5, 2018, Página(s) 699-708, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-018-1914-z

Tau Filaments and the Development of Positron Emission Tomography Tracers

Autores: Michel Goedert, Yoshiki Yamaguchi, Sushil K. Mishra, Makoto Higuchi, Naruhiko Sahara
Publicado en: Frontiers in Neurology, Edición 9, 2018, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2018.00070

Propagation of α-Synuclein Strains within Human Reconstructed Neuronal Network

Autores: Simona Gribaudo, Philippe Tixador, Luc Bousset, Alexis Fenyi, Patricia Lino, Ronald Melki, Jean-Michel Peyrin, Anselme L. Perrier
Publicado en: Stem Cell Reports, Edición 12/2, 2019, Página(s) 230-244, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2018.12.007

Structures of filaments from Pick’s disease reveal a novel tau protein fold

Autores: Benjamin Falcon, Wenjuan Zhang, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
Publicado en: Nature, Edición 561/7721, 2018, Página(s) 137-140, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-018-0454-y

Clustering of Tau fibrils impairs the synaptic composition of α3‐Na + /K + ‐ATPase and AMPA receptors

Autores: Amulya Nidhi Shrivastava, Virginie Redeker, Laura Pieri, Luc Bousset, Marianne Renner, Karine Madiona, Caroline Mailhes‐Hamon, Audrey Coens, Luc Buée, Philippe Hantraye, Antoine Triller, Ronald Melki
Publicado en: The EMBO Journal, Edición 38/3, 2019, Página(s) e99871, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201899871

Neurodegeneration and the ordered assembly of α-synuclein

Autores: Maria Grazia Spillantini, Michel Goedert
Publicado en: Cell and Tissue Research, Edición 373/1, 2018, Página(s) 137-148, ISSN 0302-766X
Editor: Springer Verlag
DOI: 10.1007/s00441-017-2706-9

Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved

Autores: Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeiro
Publicado en: Frontiers in Molecular Neuroscience, Edición 12, 2019, ISSN 1662-5099
Editor: Frontiers Research Foundation
DOI: 10.3389/fnmol.2019.00107

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Autores: Gregor Bieri, Michel Brahic, Luc Bousset, Julien Couthouis, Nicholas J. Kramer, Rosanna Ma, Lisa Nakayama, Marie Monbureau, Erwin Defensor, Birgitt Schüle, Mehrdad Shamloo, Ronald Melki, Aaron D. Gitler
Publicado en: Acta Neuropathologica, 2019, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-019-01995-0

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models

Autores: Panagiota Mavroeidi, Fedra Arvanitaki, Anastasia-Kiriaki Karakitsou, Maria Vetsi, Ismini Kloukina, Markus Zweckstetter, Karin Giller, Stefan Becker, Zachary A. Sorrentino, Benoit I. Giasson, Poul Henning Jensen, Leonidas Stefanis, Maria Xilouri
Publicado en: Acta Neuropathologica, 2019, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-019-02014-y

Assessment of the efficacy of different procedures that remove and disassemble alpha-synuclein, tau and A-beta fibrils from laboratory material and surfaces

Autores: Alexis Fenyi, Audrey Coens, Tracy Bellande, Ronald Melki, Luc Bousset
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-28856-2

Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs

Autores: Amulya Nidhi Shrivastava, Luc Bousset, Marianne Renner, Virginie Redeker, Jimmy Savistchenko, Antoine Triller, Ronald Melki
Publicado en: Biophysical Journal, 2020, ISSN 0006-3495
Editor: Biophysical Society
DOI: 10.1016/j.bpj.2020.01.022

The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding

Autores: Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki, Jean-Michel Peyrin
Publicado en: Scientific Reports, Edición 10/1, 2020, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-020-61757-x

α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Autores: Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki, Patrik Brundin
Publicado en: Acta Neuropathologica Communications, Edición 7/1, 2019, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-019-0859-3

α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities

Autores: Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen
Publicado en: Journal of Neurochemistry, Edición 150/5, 2019, Página(s) 522-534, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14808

Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification

Autores: Alexis Fenyi, Laurène Leclair-Visonneau, Thomas Clairembault, Emmanuel Coron, Michel Neunlist, Ronald Melki, Pascal Derkinderen, Luc Bousset
Publicado en: Neurobiology of Disease, Edición 129, 2019, Página(s) 38-43, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2019.05.002

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Autores: Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors HW Scheres
Publicado en: Elife, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.1101/468892

How is alpha‐synuclein cleared from the cell?

Autores: Leonidas Stefanis, Evangelia Emmanouilidou, Marina Pantazopoulou, Deniz Kirik, Kostas Vekrellis, George K. Tofaris
Publicado en: Journal of Neurochemistry, Edición 150/5, 2019, Página(s) 577-590, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.14704

Pharmacological Transdifferentiation of Human Nasal Olfactory Stem Cells into Dopaminergic Neurons

Autores: Audrey Chabrat, Emmanuelle Lacassagne, Rodolphe Billiras, Sophie Landron, Amélie Pontisso-Mahout, Hélène Darville, Alain Dupront, Francis Coge, Esther Schenker, David Piwnica, Emmanuel Nivet, François Féron, Clotilde Mannoury la Cour
Publicado en: Stem Cells International, Edición 2019, 2019, Página(s) 1-15, ISSN 1687-966X
Editor: Hindawi
DOI: 10.1155/2019/2945435

The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration

Autores: Taxiarchis Katsinelos, Benjamin J. Tuck, Aamir S. Mukadam, William A. McEwan
Publicado en: Frontiers in Immunology, Edición 10, 2019, ISSN 1664-3224
Editor: PMC
DOI: 10.3389/fimmu.2019.01139

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Autores: Benjamin Falcon, Jasenko Zivanov, Wenjuan Zhang, Alexey G. Murzin, Holly J. Garringer, Ruben Vidal, R. Anthony Crowther, Kathy L. Newell, Bernardino Ghetti, Michel Goedert, Sjors H. W. Scheres
Publicado en: Nature, Edición 568/7752, 2019, Página(s) 420-423, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1026-5

Structures of α-synuclein filaments from multiple system atrophy

Autores: Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G. Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H. W. Scheres, Michel Goedert
Publicado en: Nature, 2020, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-020-2317-6

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

Autores: Anke Van der Perren, Géraldine Gelders, Alexis Fenyi, Luc Bousset, Filipa Brito, Wouter Peelaerts, Chris Van den Haute, Steve Gentleman, Ronald Melki, Veerle Baekelandt
Publicado en: Acta Neuropathologica, Edición 139/6, 2020, Página(s) 977-1000, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-020-02157-3

Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts

Autores: Margaux Teil, Marie-Laure Arotcarena, Emilie, Faggiani Florent Laferriere, Erwan Bezard, Benjamin Dehay
Publicado en: Biomolecules, 2022, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom10030391

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Autores: Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker
Publicado en: Acta Neuropathologica Communications, Edición 8/1, 2020, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-020-00993-8

Structure-based classification of tauopathies

Autores: Yang Shi, Wenjuan Zhang, Yang Yang, Alexey G. Murzin, Benjamin Falcon, Abhay Kotecha, Mike van Beers, Airi Tarutani, Fuyuki Kametani, Holly J. Garringer, Ruben Vidal, Grace I. Hallinan, Tammaryn Lashley, Yuko Saito, Shigeo Murayama, Mari Yoshida, Hidetomo Tanaka, Akiyoshi Kakita, Takeshi Ikeuchi, Andrew C. Robinson, David M. A. Mann, Gabor G. Kovacs, Tamas Revesz, Bernardino Ghetti, Masato Hasegaw
Publicado en: Nature, Edición 598/7880, 2021, Página(s) 359-363, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03911-7

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Autores: Ruth E. Uhlmann1,2,3,*, Christine Rother1,2,3,*, Jay Rasmussen1,2,3, Juliane Schelle1,2, Carina Bergmann1, Emily M. Ullrich Gavilanes1,3, Sarah K. Fritschi1,2, Anika Buehler1,2, Frank Baumann1,2, Angelos Skodras1,2, Rawaa Al-Shaana1,2, Natalie Beschorner1,2, Lan Ye1,2, Stephan A. Kaeser1,2, Ulrike Obermüller1,2, Søren Christensen4, Fredrik Kartberg4, Jeffrey B. Stavenhagen4, Jens-Ulrich Rahfeld5
Publicado en: Nature Neuroscience, 2020, ISSN 1546-1726
Editor: Nature
DOI: 10.5281/zenodo.4562254

Phenotypic manifestation of α-synuclein strainsderived from Parkinson’s disease and multiplesystem atrophy in human dopaminergic neurons

Autores: Benedict Tanudjojo; Samiha S. Shaikh; Alexis Fenyi; Luc Bousset; Devika Agarwal; Jade Marsh; Christos Zois; Sabrina Heman-Ackah; Roman Fischer; David Sims; Ronald Melki; George K. Tofaris
Publicado en: Nature Communications, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-23682-z

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons

Autores: Francesca De Giorgi, Florent Laferrière, Federica Zinghirino, Emilie Faggiani, Alons Lends, Mathilde Bertoni, Xuan Yu, Axelle Grélard, Estelle Morvan, Birgit Habenstein, Nathalie Dutheil, Evelyne Doudnikoff, Jonathan Daniel, Stéphane Claverol, Chuan Qin, Antoine Loquet, Erwan Bezard, François Ichas
Publicado en: Science Advances, Edición 6/40, 2020, Página(s) eabc4364, ISSN 2375-2548
Editor: Science Advances
DOI: 10.1126/sciadv.abc4364

Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy

Autores: Guerrero-Ferreira, Ricardo; Taylor, Nicholas M..; Arteni, Ana-Andrea; Kumari, Pratibha; Mona, Daniel; Ringler, Philippe; Britschgi, Markus; Lauer, Matthias E.; Makky, Ali; Verasdock, Joeri; Riek, Roland; Melki, Ronald; Meier, Beat H.; Böckmann, Anja; Bousset, Luc; Stahlberg, Henning
Publicado en: eLife, Edición 2050084X, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.48907

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Inhibiting Misfolded protein PRopagation in Neurodegenerative Diseases - Sofia ref.: 116060

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