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Big Data 4 Better Hearts - Sofia ref.: 116074

Objective

Despite remarkable progress in the management of cardiovascular disease (CVD), major unmet needs remain with regard to mortality, hospitalisations, quality of life (QoL), healthcare expenditures and productivity. Acute coronary syndrome (ACS), atrial fibrillation (AF) and heart failure (HF) are major and growing components of the global CVD burden. Optimal management of these conditions is complicated by their complex aetiology and heterogeneous prognoses. Poor definition at the molecular level and co/multi-morbidities form major challenges for the development and delivery of targeted treatments. This renders response to therapy unpredictable, with large inter-individual variation and, importantly, small or undetectable treatment effects in large trials of unselected patients.

Today’s treatment guidelines still reflect the scientific constraints of an earlier era where clinical markers to guide therapy are limited to conventional risk factors and end-organ damage, and where the main endpoint in clinical trials is patient death. Hence, drug development pipelines from early target validation through to late post-marketing work have proven to be slow, expensive and high-risk: the chance of eventual approval for a CVD drug candidate in Phase I trials is 7%, the lowest of any disease category (shared with oncology) 2. Moreover, tolerability of medication and adherence to treatment show wide variations. There is thus a need for better definition of these diseases, their markers and endpoints (including better segmentation of current heterogeneous patient groups acknowledging underlying mechanisms and comorbidities) and of their outcomes/prognoses (including functional capacity and quality of life [QoL]).

BigData@Heart’s ultimate goal is to develop a Big Data--driven translational research platform of unparalleled scale and phenotypic resolution in order to deliver clinically relevant disease phenotypes, scalable insights from real-world evidence and insights driving

Call for proposal

H2020-JTI-IMI2-2015-07-two-stage
See other projects for this call

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 4 047 075

Participants (18)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 929 375
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
SOCIETE EUROPEENNE DE CARDIOLOGIE
France
EU contribution
€ 874 688
Address
Route Des Colles 2035
06903 Biot Sophia Antipolis
Activity type
Other
EUROPEAN HEART NETWORK AISBL
Belgium
EU contribution
€ 150 800
Address
Rue Montoyer 31
1000 Bruxelles
Activity type
Other
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 1 136 250
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 391 845
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
INTERNATIONAL CONSORTIUM FOR HEALTHOUTCOMES MEASUREMENT INC.
United States
EU contribution
€ 319 375
Address
14 Arrow Street Suite 11
02215 Cambridge Ma
Activity type
Other
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA
Spain
EU contribution
€ 386 250
Address
Av Menendez Pelayo 4
46010 Valencia
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 200 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 386 250
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
STICHTING MLC FOUNDATION
Netherlands
EU contribution
€ 116 812
Address
Dagelijske Groenmarkt 2
2513 AL Den Haag
Activity type
Other
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 200 000
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 200 000
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
BAYER AKTIENGESELLSCHAFT
Germany
EU contribution
€ 0
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 0
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS
France
EU contribution
€ 0
Address
Rue Carnot 50
92284 Courbevoie
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SOMALOGIC INC
United States
EU contribution
€ 0
Address
Wilderness Place 2945
80301 Boulder Colorado
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
VIFOR (INTERNATIONAL) AG
Switzerland
EU contribution
€ 0
Address
Rechenstrasse 37
9014 St Gallen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE HYVE BV
Netherlands
EU contribution
€ 326 250
Address
Arthur Van Schendelstraat 650
3511 MJ Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)