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Big Data 4 Better Hearts - Sofia ref.: 116074

Deliverables

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Publications

Big Data in Cardiovascular Disease

Author(s): Stefan Anker, Folkert Wouter Asselbergs, Gunnar Brobert, Panos Vardas, Diederick E Grobbee, Maureen Cronin
Published in: European Heart Journal, Issue 38/24, 2017, Page(s) 1863-1865, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehx283

Big data from electronic health records for early and late translational cardiovascular research: challenges and potential

Author(s): Harry Hemingway, Folkert W Asselbergs, John Danesh, Richard Dobson, Nikolaos Maniadakis, Aldo Maggioni, Ghislaine JM van Thiel, Maureen Cronin, Gunnar Brobert, Panos Vardas, Stefan D Anker, Diederick E Grobbee, Spiros Denaxas, Diederick E Grobbee, Folkert Asselbergs, Arno Hoes, Ghislaine van Thiel, Hans van Delden, René Eijkemans, Rolf Groenwold, Pieter Stolk, Olaf Klungel, Stefan D Anker, Gerd P
Published in: European Heart Journal, 2017, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehx487

From lipid locus to drug target through human genomics

Author(s): Sander W van der Laan, Eric L Harshfield, Daiane Hemerich, David Stacey, Angela M Wood, Folkert W Asselbergs
Published in: Cardiovascular Research, 2018, ISSN 0008-6363
DOI: 10.1093/cvr/cvy120

Responsible data sharing in international health research: a systematic review of principles and norms

Author(s): Shona Kalkman, Menno Mostert, Christoph Gerlinger, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel
Published in: BMC Medical Ethics, Issue 20/1, 2019, ISSN 1472-6939
DOI: 10.1186/s12910-019-0359-9

Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records

Author(s): Alicia Uijl, Stefan Koudstaal, Kenan Direk, Spiros Denaxas, Rolf H. H. Groenwold, Amitava Banerjee, Arno W. Hoes, Harry Hemingway, Folkert W. Asselbergs
Published in: European Journal of Heart Failure, 2019, ISSN 1388-9842
DOI: 10.1002/ejhf.1350

An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors

Author(s): Johannes M I H Gho, Amand F Schmidt, Laura Pasea, Stefan Koudstaal, Mar Pujades-Rodriguez, Spiros Denaxas, Anoop D Shah, Riyaz S Patel, Chris P Gale, Arno W Hoes, John G Cleland, Harry Hemingway, Folkert W Asselbergs
Published in: BMJ Open, Issue 8/3, 2018, Page(s) e018331, ISSN 2044-6055
DOI: 10.1136/bmjopen-2017-018331

UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER

Author(s): Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Natalie K Fitzpatrick, Ghazaleh Fatemifar, Amitava Banerjee, Richard J B Dobson, Laurence J Howe, Valerie Kuan, R Tom Lumbers, Laura Pasea, Riyaz S Patel, Anoop D Shah, Aroon D Hingorani, Cathie Sudlow, Harry Hemingway
Published in: Journal of the American Medical Informatics Association, Issue 26/12, 2019, Page(s) 1545-1559, ISSN 1527-974X
DOI: 10.1093/jamia/ocz105

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

Author(s): Laura Pasea, Sheng-Chia Chung, Mar Pujades-Rodriguez, Anoop D. Shah, Samantha Alvarez-Madrazo, Victoria Allan, James T. Teo, Daniel Bean, Reecha Sofat, Richard Dobson, Amitava Banerjee, Riyaz S. Patel, Adam Timmis, Spiros Denaxas, Harry Hemingway
Published in: BMC Medicine, Issue 17/1, 2019, ISSN 1741-7015
DOI: 10.1186/s12916-019-1438-y

Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis

Author(s): Amitava Banerjee, Victoria Allan, Spiros Denaxas, Anoop Shah, Dipak Kotecha, Pier D Lambiase, Jacob Joseph, Lars H Lund, Harry Hemingway
Published in: EP Europace, Issue 21/12, 2019, Page(s) 1776-1784, ISSN 1099-5129
DOI: 10.1093/europace/euz220

Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data

Author(s): Daniel M. Bean, James Teo, Honghan Wu, Ricardo Oliveira, Raj Patel, Rebecca Bendayan, Ajay M. Shah, Richard J. B. Dobson, Paul A. Scott
Published in: PLOS ONE, Issue 14/11, 2019, Page(s) e0225625, ISSN 1932-6203
DOI: 10.1371/journal.pone.0225625

Genetic determinants of lipids and cardiovascular disease outcomes: a wide-angled Mendelian randomization investigation​

Author(s): Elias Allara, Gabriele Morani, Paul Carter, Apostolos Gkatzionis, Verena Zuber, Christopher N Foley, Jessica MB Rees, Amy M Mason, Steven Bell, Dipender Gill, Adam S Butterworth, Emanuele Di Angelantonio, James Peters, Stephen Burgess
Published in: Circ Genom Precis Med, 2019, ISSN 2574-8300
DOI: 10.1101/668970

Responsible data sharing in a big data-driven translational research platform: lessons learned

Author(s): S. Kalkman, M. Mostert, N. Udo-Beauvisage, J. J. van Delden, G. J. van Thiel
Published in: BMC Medical Informatics and Decision Making, Issue 19/1, 2019, ISSN 1472-6947
DOI: 10.1186/s12911-019-1001-y

Association between beta‐blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score‐matched analysis from the Swedish Heart Failure Registry

Author(s): Davide Stolfo, Alicia Uijl, Lina Benson, Benedikt Schrage, Marat Fudim, Folkert W. Asselbergs, Stefan Koudstaal, Gianfranco Sinagra, Ulf Dahlström, Giuseppe Rosano, Gianluigi Savarese
Published in: European Journal of Heart Failure, Issue 22/1, 2019, Page(s) 103-112, ISSN 1388-9842
DOI: 10.1002/ejhf.1615

Patients’ and public views and attitudes towards the sharing of health data for research: a narrative review of the empirical evidence

Author(s): Shona Kalkman, Johannes van Delden, Amitava Banerjee, Benoît Tyl, Menno Mostert, Ghislaine van Thiel
Published in: Journal of Medical Ethics, 2019, Page(s) medethics-2019-105651, ISSN 0306-6800
DOI: 10.1136/medethics-2019-105651

Association Between Use of Primary-Prevention Implantable Cardioverter-Defibrillators and Mortality in Patients With Heart Failure

Author(s): Benedikt Schrage, Alicia Uijl, Lina Benson, Dirk Westermann, Marcus Ståhlberg, Davide Stolfo, Ulf Dahlström, Cecilia Linde, Frieder Braunschweig, Gianluigi Savarese
Published in: Circulation, Issue 140/19, 2019, Page(s) 1530-1539, ISSN 0009-7322
DOI: 10.1161/circulationaha.119.043012

Development of an international standard set of outcome measures for patients with atrial fibrillation: a report of the International Consortium for Health Outcomes Measurement (ICHOM) atrial fibrillation working group

Author(s): William H Seligman, Zofia Das-Gupta, Adedayo O Jobi-Odeneye, Elena Arbelo, Amitava Banerjee, Andreas Bollmann, Bridget Caffrey-Armstrong, Daniel A Cehic, Ramon Corbalan, Michael Collins, Gopi Dandamudi, Prabhakaran Dorairaj, Matthew Fay, Isabelle C Van Gelder, Shinya Goto, Christopher B Granger, Bathory Gyorgy, Jeff S Healey, Jeroen M Hendriks, Mellanie True Hills, F D Richard Hobbs, Menno V Huism
Published in: European Heart Journal, Issue 41/10, 2020, Page(s) 1132-1140, ISSN 0195-668X
DOI: 10.1093/eurheartj/ehz871

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Author(s): Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Michael P. Morley, Mark D. Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G. Aragam, Johan Ärnlöv, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Jeffrey Brandimarto, Michael R. Brown, Leonard Buckbinder,
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-019-13690-5

Comorbidities and cause-specific outcomes in heart failure across the ejection fraction spectrum: A blueprint for clinical trial design

Author(s): Gianluigi Savarese, Camilla Settergren, Benedikt Schrage, Tonje Thorvaldsen, Ida Löfman, Ulrik Sartipy, Linda Mellbin, Andrea Meyers, Soulmaz Fazeli Farsani, Martina Brueckmann, Kimberly G. Brodovicz, Ola Vedin, Folkert W. Asselbergs, Ulf Dahlström, Francesco Cosentino, Lars H. Lund
Published in: International Journal of Cardiology, Issue 313, 2020, Page(s) 76-82, ISSN 0167-5273
DOI: 10.1016/j.ijcard.2020.04.068

Impact of Acute Hemoglobin Falls in Heart Failure Patients: A Population Study

Author(s): Cristina Lopez, Jose Luis Holgado, Antonio Fernandez, Inmaculada Sauri, Ruth Uso, Jose Luis Trillo, Sara Vela, Carlos Bea, Julio Nuñez, Ana Ferrer, Javier Gamez, Adrian Ruiz, Josep Redon
Published in: Journal of Clinical Medicine, Issue 9/6, 2020, Page(s) 1869, ISSN 2077-0383
DOI: 10.3390/jcm9061869

Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study

Author(s): Amitava Banerjee, Laura Pasea, Steve Harris, Arturo Gonzalez-Izquierdo, Ana Torralbo, Laura Shallcross, Mahdad Noursadeghi, Deenan Pillay, Neil Sebire, Chris Holmes, Christina Pagel, Wai Keong Wong, Claudia Langenberg, Bryan Williams, Spiros Denaxas, Harry Hemingway
Published in: The Lancet, Issue 395/10238, 2020, Page(s) 1715-1725, ISSN 0140-6736
DOI: 10.1016/s0140-6736(20)30854-0

A registry‐based algorithm to predict ejection fraction in patients with heart failure

Author(s): Alicia Uijl, Lars H. Lund, Ilonca Vaartjes, Jasper J. Brugts, Gerard C. Linssen, Folkert W. Asselbergs, Arno W. Hoes, Ulf Dahlström, Stefan Koudstaal, Gianluigi Savarese
Published in: ESC Heart Failure, 2020, ISSN 2055-5822
DOI: 10.1002/ehf2.12779

Genetic drug target validation using Mendelian randomisation

Author(s): Amand F. Schmidt, Chris Finan, Maria Gordillo-Marañón, Folkert W. Asselbergs, Daniel F. Freitag, Riyaz S. Patel, Benoît Tyl, Sandesh Chopade, Rupert Faraway, Magdalena Zwierzyna, Aroon D. Hingorani
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-16969-0