Big Data 4 Better Hearts - Sofia ref.: 116074

Project Information

BigData Heart

Grant agreement ID: 116074

DOI

10.3030/116074

Project closed

EC signature date 26 June 2017

Start date 1 March 2017

End date 28 February 2023

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 19 449 971,66

EU contribution

€ 9 664 970,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (34)

Report on regional differences in the predictors and consequences of HF and AF

Migration

Open access catalogue detailing the available datasets and associated variables in the consortium

Migration

Standard Sets and Additional metrics for HF, AF and ACS

Migration

Report on findings of the omics enriched pilot studies

Migration

Minutes of annual meetings

Also due 25, 37, 49

Final Version of the Data Management Plan

Migration

Report defining requirements for meaningful patient and public involvement in Big Data health research

Migration

Report on basic model for datasharing and -access, data mapping, curating and analysis within the consortium

Migration

Impact of COVID-19 pandemic on cardiovascular disease management and outcomes

Task 5.3: Impact of COVID-19 pandemic on cardiovascular disease management and outcomes

Annual reports, including an Ethic Report of the external Ethics Advisor

Also due 24, 36, 48, 60

Expert group consensus statements on universal definition of HF and AF

Migration

Report on novel therapeutic targets with recommendations for drug development

Migration

Report on sample assays, QC and delivery of results from enrichment measures

Migration

Report specifying 3 new pilot studies demonstrating the scientific advance of omics enrichment

Migration

Exploitation plan and periodic updates

Also due 24,, 36, 48, 60

Final sustainability plan

To ensure commercialisation of deliverables, we will  also explore the need for  the supporting infrastructure, including investigations on how to deliver the results to the users, setting direction and ensuring compliance (Task 6.4).

Report of evaluation of enrichment strategies with recommendations

Migration

Communication and dissemination plan and periodic updates

Also due 12, 24, 36, 48, 60

Outreach plan, e.g. facilitate translation of results to improve patient outcomes

Migration

Report describing sustainable data sharing and -access model

Migration

Comprehensive and systematic literature review of contemporary data sources

Migration

Document detailing distinct project image, including logo and templates for presentations

Migration

Contact database (stakeholders and key project contacts)

Migration

Data management plan

Migration

Report on new disease definitions with recommendations

Migration

Manuscript of stakeholder consensus on new disease and outcome definitions

Migration

Detailed project plan, plus tracking tools, to be maintained throughout the life of the project

Migration

Project management plans

Migration

Report on the patient-centred outcomes with recommendation for wearables in trials

Migration

"Manuscripts for (a) machine learning-based extracted disease phenotypes and sub-phenotypes and new outcomes which have been technically validated; and (b) methodology for ""big data""-driven disease definitions"

Migration

Periodic reports on advice on legal, ethical and governance issues by the Governance Committee

Also due 24, 36, 48, 60

Minutes of kick-off

Migration

Report detailing basic structure of a governance framework for data-intensive health research

Migration

Manuscript of results of registry analyses

Migration

Websites, patent fillings, videos etc. (6)

Final version of the remote monitoring platform, tested and rolled out to Android and iOS app stores

Migration

Collaborative website (intranet)

Migration

Final version and evaluation of OHDSI, the Common Data Model and developed disease phenotypes

Migration

First version of the remote monitoring platform, based on RADAR-CNS platform and deployed on Android and iOS, for capturing data for running studies in the consortium

Migration

Public website

Migration

First prototype of OHDSI data discovery and analysis platform with mapped data sources

Migration

Publications

Peer reviewed articles (104)

Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19:a multi-hospital study

Author(s): Ewan Carr, Rebecca Bendayan, Daniel Bean, Matt Stammers, Wenjuan Wang, Huayu Zhang, Thomas Searle, Zeljko Kraljevic, Anthony Shek, Hang T. T. Phan, Walter Muruet, Rishi K. Gupta, Anthony J. Shinton, Mike Wyatt, Ting Shi, Xin Zhang, Andrew Pickles, Daniel Stahl, Rosita Zakeri, Mahdad Noursadeghi, Kevin O’Gallagher, Matt Rogers, Amos Folarin, Andreas Karwath, Kristin E. Wickstrøm, Alvaro Köhn-Lu
Published in: BMC Medicine, 2021, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-020-01893-3

Statistical integration of two omics datasets using GO2PLS

Author(s): Zhujie Gu, Said el Bouhaddani, Jiayi Pei, Jeanine Houwing-Duistermaat & Hae-Won Uh
Published in: BMC Bioinformatics, 2021, ISSN 1471-2105
Publisher: BioMed Central
DOI: 10.1186/s12859-021-03958-3

Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality:observational and Mendelian randomisation analyses

Author(s): Eleni Sofianopoulou, Stephen K Kaptoge, Shoaib Afzal, Tao Jiang, Dipender Gill, Thomas E Gundersen, Thomas R Bolton, Elias Allara, Matthew G Arnold, Amy M Mason, Ryan Chung, Lisa A M Pennells, Fanchao Shi, Luanluan Sun, Peter Willeit, Nita G Forouhi, Claudia Langenberg, Stephen J Sharp, Salvatore Panico, Gunnar Engström, Olle Melander, Tammy Y N Tong, Aurora Perez-Cornago, Margareta Norberg, Inge
Published in: Lancet Diabetes Endocrinol, 2021, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/s2213-8587(21)00263-1

Selenium and cancer risk: Wide-angled Mendelian randomization analysis

Author(s): Shuai Yuan, Amy M. Mason, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Stephen Burgess, Susanna C. Larsson
Published in: CANCER GENETICS AND EPIGENETICS, 2021, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33902

Desiderata for the development of next-generation electronic health record phenotype libraries

Author(s): Martin Chapman, Shahzad Mumtaz, Luke V Rasmussen, Andreas Karwath, Georgios V Gkoutos, Chuang Gao, Dan Thayer, Jennifer A Pacheco, Helen Parkinson, Rachel L Richesson, Emily Jefferson, Spiros Denaxas, Vasa Curcin
Published in: GigaScience, 2021, ISSN 2047-217X
Publisher: Oxford Academic
DOI: 10.1093/gigascience/giab059

Rare and common genetic determinants of metabolic individuality and their effects on human health

Author(s): Praveen Surendran, Isobel D. Stewart, Victoria P. W. Au Yeung, Maik Pietzner, Johannes Raffler, Maria A. Wörheide, Chen Li, Rebecca F. Smith, Laura B. L. Wittemans, Lorenzo Bomba, Cristina Menni, Jonas Zierer, Niccolò Rossi, Patricia A. Sheridan, Nicholas A. Watkins, Massimo Mangino, Pirro G. Hysi, Emanuele Di Angelantonio, Mario Falchi, Tim D. Spector, Nicole Soranzo, Gregory A. Michelotti, Wie
Published in: Nature Medicine, 2022, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-02046-0

Transforming clinical research by involving and empowering patients— the RATE-AF randomized trial

Author(s): Karina V Bunting, Mary Stanbury, Otilia Tica, Dipak Kotecha
Published in: European Heart Journal, 2021, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab098

Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study

Author(s): Shuai Yuan , Stephen Burgess , Mike Laffan , Amy M. Mason , Martin Dichgans , Dipender Gill and Susanna C. Larsson
Published in: Journal of the American Heart Association, 2021, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.120.019644

Generalizability of randomized controlled trials in heart failure with reduced ejection fraction

Author(s): Yvonne Mei Fong Lim, Megan Molnar, Ilonca Vaartjes, Gianluigi Savarese, Marinus J C Eijkemans, Alicia Uijl, Eleni Vradi, Kiliana Suzart-Woischnik, Jasper J Brugts, Hans-Peter Brunner-La Rocca, Vanessa Blanc-Guillemaud, Fabrice Couvelard, Claire Baudier, Tomasz Dyszynski, Sandra Waechter, Lars H Lund, Arno W Hoes, Benoit Tyl, Folkert W Asselbergs, Christoph Gerlinger, Diederick E G
Published in: European Heart Journal, 2021, ISSN 2047-2404
Publisher: Oxford University Press
DOI: 10.1093/ehjqcco/qcab070

Genetically personalised organ-specific metabolic models in health and disease

Author(s): Carles Foguet, Yu Xu, Scott C. Ritchie, Samuel A. Lambert, Elodie Persyn, Artika P. Nath, Emma E. Davenport, David J. Roberts, Dirk S. Paul, Emanuele Di Angelantonio, John Danesh, Adam S. Butterworth, Christopher Yau & Michael Inouye
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-35017-7

Supervised Analysis for Phenotype Identification: The Case of Heart Failure Ejection Fraction Class

Author(s): Cristina Lopez, Jose Luis Holgado, Raquel Cortes, Inma Sauri, Antonio Fernandez, Jose Miguel Calderon, Julio Nuñez and Josep Redon
Published in: Bioengineering, 2021, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/bioengineering8060085

Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements

Author(s): Qianrui Li, Xiaodan Li, Jing Wang, Hongdie Liu, Joey Sum-Wing Kwong, Hao Chen, Ling Li, Sheng-Chia Chung, Anoop Shah, Yaolong Chen, Zhenmei An, Xin Sun, Harry Hemingway, Haoming Tian, Sheyu Li
Published in: BMJ Open., 2019, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2018-026677

Sleep duration and risk of overall and 22 site‐specific cancers: A Mendelian randomization study

Author(s): Olga E. Titova, Karl Michaëlsson, Mathew Vithayathil, Amy M. Mason, Siddhartha Kar, Stephen Burgess, Susanna C. Larsson
Published in: International Journal of Cancer, Issue 148/4, 2021, Page(s) 914-920, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.33286

Assessing the feasibility of a web-based outcome measurement system in child and adolescent mental health services – myHealthE a randomised controlled feasibility pilot study

Author(s): Anna C. Morris, Zina Ibrahim, Margaret Heslin, Omer S. Moghraby, Argyris Stringaris, Ian M. Grant, Lukasz Zalewski, Megan Pritchard, Robert Stewart, Matthew Hotopf, Andrew Pickles, Richard J. B. Dobson, Emily Simonoff, Johnny Downs
Published in: Child and Adolescent Mental Health, 2022, ISSN 1475-357X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/camh.12571

Acute kidney injury in heart failure: a population study

Author(s): Jose Luis Holgado, Cristina Lopez, Antonio Fernandez, Inmaculada Sauri, Ruth Uso, Jose Luis Trillo, Sara Vela, Julio Nuñez, Josep Redon, Adrian Ruiz
Published in: ESC Heart Failure, Issue 7/2, 2020, Page(s) 415-422, ISSN 2055-5822
Publisher: Wiley Online Library
DOI: 10.1002/ehf2.12595

Artificial intelligence to enhance clinical value across the spectrum of cardiovascular healthcare

Author(s): Simrat K Gill, Andreas Karwath, Hae-Won Uh, Victor Roth Cardoso, Zhujie Gu, Andrey Barsky, Luke Slater, Animesh Acharjee, Jinming Duan, Lorenzo Dall'Olio, Said el Bouhaddani, Saisakul Chernbumroong, Mary Stanbury, Sandra Haynes, Folkert W Asselbergs, Diederick E Grobbee, Marinus J C Eijkemans, Georgios V Gkoutos, Dipak Kotecha, BigData@Heart Consortium and the cardAIc group
Published in: European Heart Journal, 2023, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac758

The genomics of heart failure: design and rationale of the HERMES consortium

Author(s): R. Thomas Lumbers, Sonia Shah, Honghuang Lin, Tomasz Czuba, Albert Henry, Daniel I. Swerdlow, Anders Mälarstig, Charlotte Andersson, Niek Verweij, Michael V. Holmes, Johan Ärnlöv, Per Svensson, Harry Hemingway, Neneh Sallah, Peter Almgren, Krishna G. Aragam, Geraldine Asselin, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Eric Boersma, Jeffrey Brandimarto, Michael R. Brown, Hans-Peter Bru
Published in: ESC Heart Failure, 2021, ISSN 2055-5822
Publisher: John Wiley & Sons
DOI: 10.1002/ehf2.13517

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition

Author(s): Johannes Kettunen, Michael V Holmes, Elias Allara, Olga Anufrieva, Pauli Ohukainen, Clare Oliver-Williams, Qin Wang, Therese Tillin, Alun D Hughes, Mika Kähönen, Terho Lehtimäki, Jorma Viikari, Olli T Raitakari, Veikko Salomaa, Marjo-Riitta Järvelin, Markus Perola, George Davey Smith, Nish Chaturvedi, John Danesh, Emanuele Di Angelantonio, Adam S Butterworth, Mika Ala-Korpela
Published in: PLOS BIOLOGY, 2019, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3000572

A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

Author(s): Steven Bell, Andreas S. Rigas, Magnus K. Magnusson, Egil Ferkingstad, Elias Allara, Gyda Bjornsdottir, Anna Ramond, Erik Sørensen, Gisli H. Halldorsson, Dirk S. Paul, Kristoffer S. Burgdorf, Hannes P. Eggertsson, Joanna M. M. Howson, Lise W. Thørner, Snaedis Kristmundsdottir, William J. Astle, Christian Erikstrup, Jon K. Sigurdsson, Dragana Vuckovic, Khoa M. Dinh, Vinicius Tragante, Praveen Sure
Published in: communications biology, 2021, ISSN 2399-3642
Publisher: Nature Research
DOI: 10.1038/s42003-020-01575-z

Estimating the Population Benefits of Blood Pressure Lowering: A Wide‐Angled Mendelian Randomization Study in UK Biobank

Author(s): Hannah Higgins , Amy M. Mason , Susanna C. Larsson , Dipender Gill , Claudia Langenberg and Stephen Burgess
Published in: Journal of the American Heart Association, 2021, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.121.021098

Association between renin–angiotensin–aldosterone system inhibitor use and COVID‐19 hospitalization and death: a 1.4 million patient nationwide registry analysis

Author(s): Gianluigi Savarese, Lina Benson, Johan Sundström, Lars H. Lund
Published in: European Journal of Heart Failure, Issue 23/3, 2021, Page(s) 476-485, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.2060

An agenda-setting paper on data sharing platforms: euCanSHare workshop

Author(s): Thijs Devriendt; Clemens Ammann; Folkert W. Asselberghs; Alexander Bernier; Rodrigo Costas; Matthias G. Friedrich; Josep Lluís Gelpí; Josep Lluís Gelpí; Marjo-Riitta Järvelin; Kari Kuulasmaa; Karim Lekadir; Michaela Th. Mayrhofer; Vaclav Papez; Gerard Pasterkamp; Steffen E. Petersen; Carsten Oliver Schmidt; Jeanette Schulz-Menger; Jeanette Schulz-Menger; Stefan Söderberg; Mahsa Shabani; Giov
Published in: Open Research Europe, Issue 38, 2021, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.12688/openreseurope.13860.1

Accurate detection of atrial fibrillation using a smartphone remains uncertain: a systematic review and meta-analysis

Author(s): Gill, S ; Sartini, C ; Uh, H.W ; Ghoreishi, N ; Cardoso, V ; Bunting, K.V ; Gkoutos, G ; Suzart-Woischnik, K ; Asselbergs, F.W ; Eijkemans, M.J.C ; Kotecha, D
Published in: European Heart Journal, 2020, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/ehjci/ehaa946.3505

Prediction of vascular aging based on smartphone acquired PPG signals

Author(s): Lorenzo Dall’Olio, Nico Curti, Daniel Remondini, Yosef Safi Harb, Folkert W. Asselbergs, Gastone Castellani, Hae-Won Uh
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-76816-6

Clinical characteristics, causes and predictors of outcomes in patients with in-hospital cardiac arrest: results from the SURVIVE-ARREST study

Author(s): Laura Erika Maria Hannen, Betül Toprak, Jessica Weimann, Bahara Mahmoodi, Nina Fluschnik, Benedikt Schrage, Kevin Roedl, Gerold Söffker, Stefan Kluge, Malte Issleib, Stefan Blankenberg, Paulus Kirchhof, Peter Clemmensen, Christoph Sinning, Elvin Zengin-Sahm & Peter Moritz Becher
Published in: Clinical Research in Cardiology, 2022, ISSN 1861-0692
Publisher: D. Steinkopff-Verlag
DOI: 10.1007/s00392-022-02084-1

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

Author(s): Dipender Gill , Marios Arvanitis , Paul Carter , Ana I. Hernández Cordero , Brian Jo , Ville Karhunen , Susanna C. Larsson , Xuan Li , Sam M. Lockhart , Amy Mason , Evanthia Pashos , Ashis Saha , Vanessa Y. Tan , Verena Zuber , Yohan Bossé , Sarah Fahle , Ke Hao , Tao Jiang , Philippe Joubert , Alan C. Lunt† , Willem Hendrik Ouwehand , David J. Roberts , Wim Timens , Maarten van den Berge , Ni
Published in: Royal Society Open Science, 2020, ISSN 2054-5703
Publisher: Royal Society
DOI: 10.1098/rsos.200958

Patient profile and outcomes associated with follow-up in specialty vs. primary care in heart failure

Author(s): Felix Lindberg, Lars H. Lund, Lina Benson, Benedikt Schrage, Magnus Edner, Ulf Dahlström, Cecilia Linde, Giuseppe Rosano, Gianluigi Savarese
Published in: ESC Heart Failure, 2022, Page(s) 822-833, ISSN 2055-5822
Publisher: Wiley
DOI: 10.1002/ehf2.13848

Patients’ and Publics’ Preferences for Data-Intensive Health Research Governance: Survey Study

Author(s): Sam H A Muller, Ghislaine J M W van Thiel, Marilena Vrana, Menno Mostert, Johannes J M van Delden
Published in: JMIR Human Factors, 2022, ISSN 2292-9495
Publisher: JMIR Publications Inc.
DOI: 10.2196/36797

Aortic root dimensions as a correlate for aortic regurgitation’s severity

Author(s): Jan-Per Wenzel, Elina Petersen, Julius Nikorowitsch, Jessica Müller, Tilo Kölbel, Hermann Reichenspurner, Stefan Blankenberg & Evaldas Girdauskas
Published in: The International Journal of Cardiovascular Imaging, 2021, ISSN 1875-8312
Publisher: Springer Netherlands
DOI: 10.1007/s10554-021-02337-6

Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study

Author(s): Amitava Banerjee, Laura Pasea, Steve Harris, Arturo Gonzalez-Izquierdo, Ana Torralbo, Laura Shallcross, Mahdad Noursadeghi, Deenan Pillay, Neil Sebire, Chris Holmes, Christina Pagel, Wai Keong Wong, Claudia Langenberg, Bryan Williams, Spiros Denaxas, Harry Hemingway
Published in: Lancet, 2020, Page(s) 1715-1725, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(20)30854-0

A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential

Author(s): Amitava Banerjee, Laura Pasea, Sheng-Chia Chung, Kenan Direk, Folkert Asselbergs, Diederick E. Grobbee, Dipak Kotecha, Stefan D. Anker, Tomasz Dyszynski, Benoît Tyl, Spiros Denaxas, R. Thomas Lumbers, Harry Hemingway
Published in: European Heart Journal of Heart Failure, 2021, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.2417

Excess deaths in people with cardiovascular diseases during the COVID-19 pandemic

Author(s): Amitava Banerjee, Suliang Chen, Laura Pasea, Alvina G Lai, Michail Katsoulis, Spiros Denaxas, Vahe Nafilyan, Bryan Williams, Wai Keong Wong, Ameet Bakhai, Kamlesh Khunti, Deenan Pillay, Mahdad Noursadeghi, Honghan Wu, Nilesh Pareek, Daniel Bromage, Theresa A McDonagh, Jonathan Byrne, James T H Teo, Ajay M Shah, Ben Humberstone, Liang V Tang, Anoop S V Shah, Andrea Rubboli, Yutao Guo, Yu Hu, Cathie
Published in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4881
Publisher: Oxford University Press (OUP)
DOI: 10.1093/eurjpc/zwaa155

Transforming and evaluating the UK Biobank to the OMOP Common Data Model for COVID-19 research and beyond

Author(s): Vaclav Papez, Maxim Moinat, Erica A Voss, Sofia Bazakou, Anne Van Winzum, Alessia Peviani, Stefan Payralbe, Elena Garcia Lara, Michael Kallfelz, Folkert W Asselbergs, Daniel Prieto-Alhambra, Richard J B Dobson, Spiros Denaxas
Published in: Journal of the American Medical Informatics Association, 2023, ISSN 1527-974X
Publisher: Zenodo
DOI: 10.1093/jamia/ocac203

Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

Author(s): Jasmeet S. Reyat, Winnie Chua, Victor R. Cardoso, Anika Witten, Peter M. Kastner, S. Nashitha Kabir, Moritz F. Sinner, Robin Wesselink, Andrew P. Holmes, Davor Pavlovic, Monika Stoll, Stefan Kaeaeb, Georgios Gkoutos, Joris R. de Groot, Paulus Kirchhof, Larissa Fabritz
Published in: JCI INSIGHT, 2020, ISSN 2379-3708
Publisher: American Society for Clinical investigation
DOI: 10.1172/jci.insight.139179

Predictors of primary prevention implantable cardioverter-defibrillator use in heart failure with reduced ejection fraction: impact of the predicted risk of sudden cardiac death and all-cause mortality

Author(s): Benedikt Schrage, Lars H. Lund, Lina Benson, Ulf Dahlström, Ramin Shadman, Cecilia Linde, Frieder Braunschweig, Wayne C. Levy, Gianluigi Savarese
Published in: European Journal of Heart Failure, 2022, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.2530

CODE-EHR best-practice framework for the use of structured electronic health-care records in clinical research

Author(s): Dipak Kotecha, Folkert W Asselbergs, Stephan Achenbach, Stefan D Anker, Dan Atar, Colin Baigent, Amitava Banerjee, Birgit Beger, Gunnar Brobert, Barbara Casadei, Cinzia Ceccarelli, Martin R Cowie, Filippo Crea, Maureen Cronin, Spiros Denaxas, Andrea Derix, Donna Fitzsimons, Martin Fredriksson, Chris P Gale, Georgios V Gkoutos, Wim Goettsch, Harry Hemingway, Martin Ingvar, Adrian Jonas, Robert Kazm
Published in: The Lancet, 2022, ISSN 2589-7500
Publisher: Elsevier
DOI: 10.1016/s2589-7500(22)00151-0

Natural language processing for disease phenotyping in UK primary care records for research: a pilot study in myocardial infarction and death

Author(s): Anoop D. Shah, Emily Bailey, Tim Williams, Spiros Denaxas, Richard Dobson, Harry Hemingway
Published in: Journal of Biomedical Semantics, 2019, ISSN 2041-1480
Publisher: BMC
DOI: 10.1186/s13326-019-0214-4

Identification and Mapping Real-World Data Sources for Heart Failure, Acute Coronary Syndrome, and Atrial Fibrillation

Author(s): Studer R.a · Sartini C.b · Suzart-Woischnik K.b · Agrawal R.c · Natani H.c · Gill S.K.d · Wirta S.B.a · Asselbergs F.W.e,f · Dobson R.e · Denaxas S.e · Kotecha D.d,f,g
Published in: Cardiology, 2021, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1159/000520674

Machine learning: a long way from implementation in cardiovascular disease

Author(s): Suliang Chen, Amitava Banerjee
Published in: Heart, Issue 106/5, 2020, Page(s) 318-320, ISSN 1355-6037
Publisher: BMJ Publishing Group
DOI: 10.1136/heartjnl-2019-316030

Transthoracic echocardiographic reference values of the aortic root: results from the Hamburg City Health Study

Author(s): Jan-Per Wenzel, Elina Petersen, Julius Nikorowitsch, Juliana Senftinger, Christoph Sinning, Matthias Theissen, Johannes Petersen, Hermann Reichenspurner & Evaldas Girdauskas
Published in: The International Journal of Cardiovascular Imaging, 2021, ISSN 1875-8312
Publisher: Springer Netherlands
DOI: 10.1007/s10554-021-02354-5

Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study

Author(s): Shuai Yuan, Amy M. Mason, Stephen Burgess & Susanna C. Larsson
Published in: European Journal of Epidemiology, 2021, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-021-00737-5

Estimating the Effect of Reduced Attendance at Emergency Departments for Suspected Cardiac Conditions on Cardiac Mortality During the COVID-19 Pandemic

Author(s): Michail Katsoulis , Manuel Gomes , Alvina G. Lai , Albert Henry , Spiros Denaxas , Pagona Lagiou , Vahe Nafilyan , Ben Humberstone , Amitava Banerjee , Harry Hemingway and R. Thomas Lumbers
Published in: Circulation: Cardiovascular Quality and Outcomes, 2021, ISSN 1941-7713
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circoutcomes.120.007085

Post-mortem examination of high mortality in patients with heart failure and atrial fibrillation

Author(s): Otilia Țica, Ovidiu Țica, Karina V. Bunting, Joseph deBono, Georgios V. Gkoutos, Mircea I. Popescu & Dipak Kotecha
Published in: BMC Medicine, 2022, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-022-02533-8

Association between dosing and combination use of medications and outcomes in heart failure with reduced ejection fraction: data from the Swedish Heart Failure Registry

Author(s): Domenico D'Amario, Daniele Rodolico, Giuseppe M.C. Rosano, Ulf Dahlström, Filippo Crea, Lars H. Lund, Gianluigi Savarese
Published in: European Journal of Heart Failure, 2022, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.2477

Million Migrants study of healthcare and mortality outcomes in non-EU migrants and refugees to England: Analysis protocol for a linked population-based cohort study of 1.5 million migrants

Author(s): Rachel Burns, Neha Pathak, Ines Campos-Matos, Dominik Zenner, Srinivasa Vittal Katikireddi, Morris C. Muzyamba, J. Jaime Miranda, Ruth Gilbert, Harry Rutter, Lucy Jones, Elizabeth J. Williamson, Andrew C. Hayward, Liam Smeeth, Ibrahim Abubakar, Harry Hemingway, Robert W. Aldridge
Published in: Wellcome Open Research, 2019, ISSN 2398-502X
Publisher: F1000Research
DOI: 10.12688/wellcomeopenres.15007.1

Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19

Author(s): Kevin O’Gallagher, Anthony Shek, Daniel M. Bean, Rebecca Bendayan, Alexandros Papachristidis, James T. H. Teo, Richard J. B. Dobson, Ajay M. Shah, Rosita Zakeri
Published in: BMC Cardiovascular Disorders, 2021, ISSN 1471-2261
Publisher: BioMed Central
DOI: 10.1186/s12872-021-02137-9

Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study

Author(s): Shuai Yuan, Paul Carter, Amy M. Mason, Stephen Burgess and Susanna C. Larsson
Published in: Nutrients, 2021, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13072218

CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research

Author(s): Dipak Kotecha, Folkert W Asselbergs, Stephan Achenbach, Stefan D Anker, Dan Atar, Colin Baigent, Amitava Banerjee, Birgit Beger, Gunnar Brobert, Barbara Casadei, Cinzia Ceccarelli, Martin R Cowie, Filippo Crea, Maureen Cronin, Spiros Denaxas, Andrea Derix, Donna Fitzsimons, Martin Fredriksson, Chris P Gale, Georgios V Gkoutos, Wim Goettsch, Harry Hemingway, Martin Ingvar, Adrian Jonas, Robert Kazm
Published in: European Heart Journal, 2022, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac426

Anticoagulation for atrial fibrillation in people with serious mental illness in the general hospital setting

Author(s): Dina Farran, Daniel Bean, Tao Wang, Yamiko Msosa, Cecilia Casetta, Richard Dobson, James Teo, Paul Andrew Scott, Fiona Gaughran
Published in: Journal of psychiatric research, 2022, ISSN 1879-1379
Publisher: Elsevier
DOI: 10.1016/j.jpsychires.2022.06.044

Association between heart failure quality of care and mortality: a population-based cohort study using nationwide registries

Author(s): Gorav Batra, Suleman Aktaa, Lina Benson, Ulf Dahlström, Camilla Hage, Gianluigi Savarese, Peter Vasko, Chris P. Gale, Lars H. Lund
Published in: European Journal of Heart Failure, 2022, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.2725

Cabins, castles, and constant hearts: rhythm control therapy in patients with atrial fibrillation

Author(s): Stephan Willems, Christian Meyer, Joseph de Bono, Axel Brandes, Lars Eckardt, Arif Elvan, Isabelle van Gelder, Andreas Goette, Michele Gulizia, Laurent Haegeli, Hein Heidbuchel, Karl Georg Haeusler, Josef Kautzner, Lluis Mont, G Andre Ng, Lukasz Szumowski, Sakis Themistoclakis, Karl Wegscheider, Paulus Kirchhof
Published in: European Heart Journal, 2019, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehz782

A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems

Author(s): Spiros Denaxas, Anoop D Shah, Bilal A Mateen, Valerie Kuan, Jennifer K Quint, Natalie Fitzpatrick, Ana Torralbo, Ghazaleh Fatemifar, Harry Hemingway
Published in: JAMIA Open, Issue 3/4, 2020, Page(s) 545-556, ISSN 2574-2531
Publisher: Oxford Academic
DOI: 10.1093/jamiaopen/ooaa047

Electrocardiogram-based mortality prediction in patients with COVID-19 using machine learning

Author(s): R. R. van de Leur, H. Bleijendaal, K. Taha, T. Mast, J. M. I. H. Gho, M. Linschoten, B. van Rees, M. T. H. M. Henkens, S. Heymans, N. Sturkenboom, R. A. Tio, J. A. Offerhaus, W. L. Bor, M. Maarse, H. E. Haerkens-Arends, M. Z. H. Kolk, A. C. J. van der Lingen, J. J. Selder, E. E. Wierda, P. F. M. M. van Bergen, M. M. Winter, A. H. Zwinderman, P. A. Doevendans, P. van der Harst, Y. M. Pinto, F. W. A
Published in: Netherlands Heart Journal, 2022, ISSN 1876-6250
Publisher: Bohn Stafleu Van Loghum B.V.
DOI: 10.1007/s12471-022-01670-2

Diastolic dysfunction in individuals with and without heart failure with preserved ejection fraction

Author(s): Jan-Per Wenzel, Ramona Bei der Kellen, Christina Magnussen, Stefan Blankenberg, Benedikt Schrage, Renate Schnabel & Julius Nikorowitsch
Published in: Clinical Research in Cardiology, 2021, ISSN 1861-0692
Publisher: D. Steinkopff-Verlag
DOI: 10.1007/s00392-021-01907-x

An agenda-setting paper on data sharing platforms : euCanSHare workshop

Author(s): Devriendt, Thijs; Ammann, Clemens; W. Asselbergs, Folkert; Bernier, Alexander; Costas, Rodrigo; Friedrich, Matthias G.; Gelpi, Josep L.; Jarvelin, Marjo-Riitta; Kuulasmaa, Kari; Lekadir, Karim; Mayrhofer, Michaela Th.; Papez, Vaclav; Pasterkamp, Gerard; Petersen, Steffen E.; Schmidt, Carsten Oliver; Schulz-Menger, Jeanette; Söderberg, Stefan; Shabani, Mahsa; Veronesi, Giovanni; Viezzer, Darian St
Published in: Open Res Europe, Issue 1, 2021, ISSN 2732-5121
Publisher: Open Res Europe
DOI: 10.12688/openreseurope.13860.2

Systematic approach to outcome assessment from coded electronic healthcare records in the DaRe2THINK NHS-embedded randomized trial

Author(s): Xiaoxia Wang, Alastair R Mobley, Otilia Tica, Kelvin Okoth, Rebecca E Ghosh, Puja Myles, Tim Williams, Sandra Haynes, Krishnarajah Nirantharakumar, David Shukla, Dipak Kotecha, the DaRe2THINK Trial Committees
Published in: European Heart Journal - Digital Health, 2022, ISSN 2634-3916
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ehjdh/ztac046

COVID-19 infection and attributable mortality in UK care homes: Cohort study using active surveillance and electronic records (March-June 2020)

Author(s): Peter F Dutey-Magni, Haydn Williams, Arnoupe Jhass, Greta Rait, Fabiana Lorencatto, Harry Hemingway, Andrew Hayward, Laura Shallcross
Published in: Age and Ageing, 2021, ISSN 0002-0729
Publisher: Oxford University Press
DOI: 10.1093/ageing/afab060

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Author(s): Liam Gaziano, Claudia Giambartolomei, Alexandre C. Pereira, Anna Gaulton, Daniel C. Posner, Sonja A. Swanson, Yuk-Lam Ho, Sudha K. Iyengar, Nicole M. Kosik, Marijana Vujkovic, David R. Gagnon, A. Patrícia Bento, Inigo Barrio-Hernandez, Lars Rönnblom, Niklas Hagberg, Christian Lundtoft, Claudia Langenberg, Maik Pietzner, Dennis Valentine, Stefano Gustincich, Gian Gaetano Tartaglia, Elias Allara,
Published in: Nature Medicine, 2021, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-021-01310-z

Fit for the future: empowering clinical trials with digital technology

Author(s): Dipak Kotecha, Adam D DeVore, Folkert W Asselbergs
Published in: European Heart Journal, 2022, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehac650

Morning chronotype and digestive tract cancers: Mendelian randomization study

Author(s): Shuai Yuan, Amy M. Mason, Olga E. Titova, Mathew Vithayathil, Siddhartha Kar, Jie Chen, Xue Li, Stephen Burgess, Susanna C. Larsson
Published in: International Journal of Cancer, 2022, ISSN 0020-7136
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ijc.34284

Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study

Author(s): Shuai Yuan, Amy M. Mason, Paul Carter, Stephen Burgess & Susanna C. Larsson
Published in: BMC Medicine, 2021, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-021-01977-8

Effects of tumour necrosis factor on cardiovascular disease and cancer: A two-sample Mendelian randomization study

Author(s): Shuai Yuana, Paul Carter, Maria Bruzelius, Mathew Vithayathil, Siddhartha Karg, Amy M. Mason, Ang Lin, Stephen Burgess, Susanna C. Larsson
Published in: eBioMedicine, 2020, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102956

Machine learning for subtype definition and risk prediction in heart failure, acute coronary syndromes and atrial fibrillation: systematic review of validity and clinical utility

Author(s): Amitava Banerjee, Suliang Chen, Ghazaleh Fatemifar, Mohamad Zeina, R. Thomas Lumbers, Johanna Mielke, Simrat Gill, Dipak Kotecha, Daniel F. Freitag, Spiros Denaxas, Harry Hemingway
Published in: BMC Medicine, Issue 19/1, 2021, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-021-01940-7

Heart rate in patients with atrial fibrillation and heart failure with preserved ejection fraction: a prognosticator like in sinus rhythm?

Author(s): Michiel Rienstra, Dipak Kotecha, Dirk J. van Veldhuisen
Published in: European Journal of Heart Failure, Issue 21/4, 2019, Page(s) 480-481, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.1425

Big Data in Cardiovascular Disease

Author(s): Stefan Anker, Folkert Wouter Asselbergs, Gunnar Brobert, Panos Vardas, Diederick E Grobbee, Maureen Cronin
Published in: European Heart Journal, Issue 38/24, 2017, Page(s) 1863-1865, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehx283

Big data from electronic health records for early and late translational cardiovascular research: challenges and potential

Author(s): Harry Hemingway, Folkert W Asselbergs, John Danesh, Richard Dobson, Nikolaos Maniadakis, Aldo Maggioni, Ghislaine JM van Thiel, Maureen Cronin, Gunnar Brobert, Panos Vardas, Stefan D Anker, Diederick E Grobbee, Spiros Denaxas, Diederick E Grobbee, Folkert Asselbergs, Arno Hoes, Ghislaine van Thiel, Hans van Delden, René Eijkemans, Rolf Groenwold, Pieter Stolk, Olaf Klungel, Stefan D Anker, Gerd P
Published in: European Heart Journal, 2017, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehx487

From lipid locus to drug target through human genomics

Author(s): Sander W van der Laan, Eric L Harshfield, Daiane Hemerich, David Stacey, Angela M Wood, Folkert W Asselbergs
Published in: Cardiovascular Research, 2018, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvy120

Responsible data sharing in international health research: a systematic review of principles and norms

Author(s): Shona Kalkman, Menno Mostert, Christoph Gerlinger, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel
Published in: BMC Medical Ethics, Issue 20/1, 2019, ISSN 1472-6939
Publisher: BioMed Central
DOI: 10.1186/s12910-019-0359-9

Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records

Author(s): Alicia Uijl, Stefan Koudstaal, Kenan Direk, Spiros Denaxas, Rolf H. H. Groenwold, Amitava Banerjee, Arno W. Hoes, Harry Hemingway, Folkert W. Asselbergs
Published in: European Journal of Heart Failure, 2019, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.1350

An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors

Author(s): Johannes M I H Gho, Amand F Schmidt, Laura Pasea, Stefan Koudstaal, Mar Pujades-Rodriguez, Spiros Denaxas, Anoop D Shah, Riyaz S Patel, Chris P Gale, Arno W Hoes, John G Cleland, Harry Hemingway, Folkert W Asselbergs
Published in: BMJ Open, Issue 8/3, 2018, Page(s) e018331, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2017-018331

UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER

Author(s): Spiros Denaxas, Arturo Gonzalez-Izquierdo, Kenan Direk, Natalie K Fitzpatrick, Ghazaleh Fatemifar, Amitava Banerjee, Richard J B Dobson, Laurence J Howe, Valerie Kuan, R Tom Lumbers, Laura Pasea, Riyaz S Patel, Anoop D Shah, Aroon D Hingorani, Cathie Sudlow, Harry Hemingway
Published in: Journal of the American Medical Informatics Association, Issue 26/12, 2019, Page(s) 1545-1559, ISSN 1527-974X
Publisher: Oxford Academic
DOI: 10.1093/jamia/ocz105

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

Author(s): Laura Pasea, Sheng-Chia Chung, Mar Pujades-Rodriguez, Anoop D. Shah, Samantha Alvarez-Madrazo, Victoria Allan, James T. Teo, Daniel Bean, Reecha Sofat, Richard Dobson, Amitava Banerjee, Riyaz S. Patel, Adam Timmis, Spiros Denaxas, Harry Hemingway
Published in: BMC Medicine, Issue 17/1, 2019, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-019-1438-y

Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis

Author(s): Amitava Banerjee, Victoria Allan, Spiros Denaxas, Anoop Shah, Dipak Kotecha, Pier D Lambiase, Jacob Joseph, Lars H Lund, Harry Hemingway
Published in: EP Europace, Issue 21/12, 2019, Page(s) 1776-1784, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euz220

Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data

Author(s): Daniel M. Bean, James Teo, Honghan Wu, Ricardo Oliveira, Raj Patel, Rebecca Bendayan, Ajay M. Shah, Richard J. B. Dobson, Paul A. Scott
Published in: PLOS ONE, Issue 14/11, 2019, Page(s) e0225625, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0225625

Genetic determinants of lipids and cardiovascular disease outcomes: a wide-angled Mendelian randomization investigation​

Author(s): Elias Allara, Gabriele Morani, Paul Carter, Apostolos Gkatzionis, Verena Zuber, Christopher N Foley, Jessica MB Rees, Amy M Mason, Steven Bell, Dipender Gill, Adam S Butterworth, Emanuele Di Angelantonio, James Peters, Stephen Burgess
Published in: Circ Genom Precis Med, 2019, ISSN 2574-8300
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1101/668970

Responsible data sharing in a big data-driven translational research platform: lessons learned

Author(s): S. Kalkman, M. Mostert, N. Udo-Beauvisage, J. J. van Delden, G. J. van Thiel
Published in: BMC Medical Informatics and Decision Making, Issue 19/1, 2019, ISSN 1472-6947
Publisher: BioMed Central
DOI: 10.1186/s12911-019-1001-y

Association between beta‐blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score‐matched analysis from the Swedish Heart Failure Registry

Author(s): Davide Stolfo, Alicia Uijl, Lina Benson, Benedikt Schrage, Marat Fudim, Folkert W. Asselbergs, Stefan Koudstaal, Gianfranco Sinagra, Ulf Dahlström, Giuseppe Rosano, Gianluigi Savarese
Published in: European Journal of Heart Failure, Issue 22/1, 2019, Page(s) 103-112, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.1615

Patients’ and public views and attitudes towards the sharing of health data for research: a narrative review of the empirical evidence

Author(s): Shona Kalkman, Johannes van Delden, Amitava Banerjee, Benoît Tyl, Menno Mostert, Ghislaine van Thiel
Published in: Journal of Medical Ethics, 2019, Page(s) medethics-2019-105651, ISSN 0306-6800
Publisher: BMJ Publishing Group
DOI: 10.1136/medethics-2019-105651

Association Between Use of Primary-Prevention Implantable Cardioverter-Defibrillators and Mortality in Patients With Heart Failure

Author(s): Benedikt Schrage, Alicia Uijl, Lina Benson, Dirk Westermann, Marcus Ståhlberg, Davide Stolfo, Ulf Dahlström, Cecilia Linde, Frieder Braunschweig, Gianluigi Savarese
Published in: Circulation, Issue 140/19, 2019, Page(s) 1530-1539, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.119.043012

Development of an international standard set of outcome measures for patients with atrial fibrillation: a report of the International Consortium for Health Outcomes Measurement (ICHOM) atrial fibrillation working group

Author(s): William H Seligman, Zofia Das-Gupta, Adedayo O Jobi-Odeneye, Elena Arbelo, Amitava Banerjee, Andreas Bollmann, Bridget Caffrey-Armstrong, Daniel A Cehic, Ramon Corbalan, Michael Collins, Gopi Dandamudi, Prabhakaran Dorairaj, Matthew Fay, Isabelle C Van Gelder, Shinya Goto, Christopher B Granger, Bathory Gyorgy, Jeff S Healey, Jeroen M Hendriks, Mellanie True Hills, F D Richard Hobbs, Menno V Huism
Published in: European Heart Journal, Issue 41/10, 2020, Page(s) 1132-1140, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehz871

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Author(s): Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa K. Hedman, Jemma B. Wilk, Michael P. Morley, Mark D. Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Andersson, Krishna G. Aragam, Johan Ärnlöv, Joshua D. Backman, Mary L. Biggs, Heather L. Bloom, Jeffrey Brandimarto, Michael R. Brown, Leonard Buckbinder,
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-13690-5

Comorbidities and cause-specific outcomes in heart failure across the ejection fraction spectrum: A blueprint for clinical trial design

Author(s): Gianluigi Savarese, Camilla Settergren, Benedikt Schrage, Tonje Thorvaldsen, Ida Löfman, Ulrik Sartipy, Linda Mellbin, Andrea Meyers, Soulmaz Fazeli Farsani, Martina Brueckmann, Kimberly G. Brodovicz, Ola Vedin, Folkert W. Asselbergs, Ulf Dahlström, Francesco Cosentino, Lars H. Lund
Published in: International Journal of Cardiology, Issue 313, 2020, Page(s) 76-82, ISSN 0167-5273
Publisher: Elsevier BV
DOI: 10.1016/j.ijcard.2020.04.068

Impact of Acute Hemoglobin Falls in Heart Failure Patients: A Population Study

Author(s): Cristina Lopez, Jose Luis Holgado, Antonio Fernandez, Inmaculada Sauri, Ruth Uso, Jose Luis Trillo, Sara Vela, Carlos Bea, Julio Nuñez, Ana Ferrer, Javier Gamez, Adrian Ruiz, Josep Redon
Published in: Journal of Clinical Medicine, Issue 9/6, 2020, Page(s) 1869, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9061869

A registry‐based algorithm to predict ejection fraction in patients with heart failure

Author(s): Alicia Uijl, Lars H. Lund, Ilonca Vaartjes, Jasper J. Brugts, Gerard C. Linssen, Folkert W. Asselbergs, Arno W. Hoes, Ulf Dahlström, Stefan Koudstaal, Gianluigi Savarese
Published in: ESC Heart Failure, 2020, ISSN 2055-5822
Publisher: Wiley Online Library
DOI: 10.1002/ehf2.12779

Genetic drug target validation using Mendelian randomisation

Author(s): Amand F. Schmidt, Chris Finan, Maria Gordillo-Marañón, Folkert W. Asselbergs, Daniel F. Freitag, Riyaz S. Patel, Benoît Tyl, Sandesh Chopade, Rupert Faraway, Magdalena Zwierzyna, Aroon D. Hingorani
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16969-0

Genetically predicted circulating vitamin C in relation to cardiovascular disease

Author(s): Shuai Yuan, Ju-Sheng Zheng, Amy M Mason, Stephen Burgess, Susanna C Larsson
Published in: European Journal of Preventive Cardiology, 2021, ISSN 2047-4873
Publisher: SAGE Publications Ltd
DOI: 10.1093/eurjpc/zwab081

Genetically predicted circulating B vitamins in relation to digestive system cancers

Author(s): Shuai Yuan, Paul Carter, Mathew Vithayathil, Siddhartha Kar, Amy M. Mason, Stephen Burgess & Susanna C. Larsson
Published in: british journal of cancer, 2021, ISSN 0007-0920
Publisher: Nature Publishing Group
DOI: 10.1038/s41416-021-01383-0

The social licence for data-intensive health research: towards co-creation, public value and trust

Author(s): Muller SHA, Kalkman S, van Thiel GJMW, Mostert M, van Delden JJM.
Published in: BMC Medicine Ethics, 2021, ISSN 1472-6939
Publisher: BioMed Central
DOI: 10.1186/s12910-021-00677-5

Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis

Author(s): Shuai Yuan, Mathew Vithayathil, Siddhartha Kar, Paul Carter, Amy M. Mason, Shao-Hua Xie, Stephen Burgess, Susanna C. Larsson
Published in: Allergy, 2020, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.14616

Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource

Author(s): Wood, Angela; Denholm, Rachel; Hollings, Sam; Cooper, Jennifer; Ip, Samantha; Walker, Venexia; Denaxas, Spiros; Akbari, Ashley; Banerjee, Amitava; Whiteley, William; Lai, Alvina; Sterne, Jonathan; Sudlow, Cathie.
Published in: BMJ, 2021, ISSN 0959-8138
Publisher: British Medical Association
DOI: 10.1136/bmj.n826

Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension

Author(s): Daiane Hemerich, Jessica van Setten, Vinicius Tragante, Folkert W Asselbergs
Published in: Frontiers in Cardiovascular Medicine, 2018, ISSN 2297-055X
Publisher: Frontiers Media
DOI: 10.3389/fcvm.2018.00025

Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study

Author(s): Daniel Bromage, Tom R Godec, Mar Pujades-Rodriguez, Arturo Gonzalez-Izquierdo, S Denaxas, Harry Hemingway, Derek M Yellon
Published in: Cardiovascular Diabetology, 2019, ISSN 1475-2840
Publisher: BioMed Central
DOI: 10.1186/s12933-019-0972-4

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide

Author(s): Molly O’Reilly, Laura C Sommerfeld, C O’Shea, S Broadway-Stringer, S Andaleeb, J S Reyat, S N Kabir, D Stastny, A Malinova, D Delbue, L Fortmueller, K Gehmlich, D Pavlovic, B V Skryabin, A P Holmes, P Kirchhof, L Fabritz
Published in: EP Europace, 2022, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euac218

Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis

Author(s): Segun Fatumo , Ville Karhunen , Tinashe Chikowore , Toure Sounkou , Brenda Udosen , Chisom Ezenwa , Mariam Nakabuye , Opeyemi Soremekun , Iyas Daghlas , David K. Ryan , Amybel Taylor , Amy M. Mason , Scott M. Damrauer , Marijana Vujkovic , Keith L. Keene , Myriam Fornage , Marjo-Riitta Järvelin , Stephen Burgess and Dipender Gill
Published in: Stroke, 2021, ISSN 0039-2499
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/strokeaha.121.034747

Smartphone detection of atrial fibrillation using photoplethysmography: a systematic review and meta-analysis

Author(s): Simrat Gill, Karina Bunting, Claudio Sartini, Victor Roth Cardoso, Narges Ghoreishi, Hae-Won Uh, John Williams, Kiliana Suzart-Woischnik, Amitava Banerjee, Folkert Asselbergs, MJC Eijkemans, Georgios Gkoutos, Dipak Kotecha
Published in: Heart (British Cardiac Society), 2021, ISSN 1468-201X
Publisher: BMG and BCS publishing
DOI: 10.1136/heartjnl-2021-320417

Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study.

Author(s): Winnie Chua, Jonathan P Law, Victor R Cardoso, Yanish Purmah, Georgiana Neculau, Muhammad Jawad-Ul-Qamar, Kalisha Russell, Ashley Turner, Samantha P Tull, Frantisek Nehaj, Paul Brady, Peter Kastner, André Ziegler, Georgios V Gkoutos, Davor Pavlovic, Charles J Ferro, Paulus Kirchhof, Larissa Fabritz
Published in: PLoS Medicine, 2021, ISSN 1549-1277
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1003405

Long COVID: mechanisms, risk factors and recovery

Author(s): Astin, Rónan, Banerjee, Amitaya, Baker, Mark R, Lim, Phang Boon, Dani, Melanie, Ford, Elizabeth, Hull, James H, McNarry, Melitta, Morten, Karl, O’Sullivan, Oliver, Pretorius, Etheresia, Raman, Betty, Soteropoulos, Demetris S, Taquet, Maxime, Hall, Catherine
Published in: Experimental Physiology, 2022, ISSN 0958-0670
Publisher: Blackwell Publishing Inc.
DOI: 10.1113/ep090802

Identification of distinct phenotypic clusters in heart failure with preserved ejection fraction

Author(s): Alicia Uijl, Gianluigi Savarese, Ilonca Vaartjes, Ulf Dahlström, Jasper J. Brugts, Gerard C.M. Linssen, Vanessa Empel, Hans‐Peter Brunner‐La Rocca, Folkert W. Asselbergs, Lars H. Lund, Arno W. Hoes, Stefan Koudstaal
Published in: European Journal of Heart Failure, Issue 23/6, 2021, Page(s) 973-982, ISSN 1388-9842
Publisher: Elsevier BV
DOI: 10.1002/ejhf.2169

Redefining β-blocker response in heart failure patients with sinus rhythm and atrial fibrillation: a machine learning cluster analysis

Author(s): Karwath A, Bunting KV, Gill SK, Tica O, Pendleton S, Aziz F, Barsky AD, Chernbumroong S, Duan J, Mobley AR, Cardoso VR, Slater L, Williams JA, Bruce EJ, Wang X, Flather MD, Coats AJS, Gkoutos GV, Kotecha D
Published in: Lancet, 2021, ISSN 0140-6736
Publisher: The Lancet Publishing Group
DOI: 10.1016/s0140-6736(21)01638-x

Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial

Author(s): Andreas Metzner, Anna Suling, Axel Brandes, , Günter Breithardt, A John Camm, Harry J G M Crijns, , Lars Eckardt, , Arif Elvan, , Andreas Goette, , Laurent M Haegeli, , Hein Heidbuchel, , Josef Kautzner, , Karl-Heinz Kuck, , Luis Mont, G Andre Ng, , Lukasz Szumowski, , Sakis Themistoclakis, , Isabelle C van Gelder, , Panos Vardas, , Karl Wegscheider, , Stephan Willems, Paulus Kirchhof
Published in: EP Europace, 2021, ISSN 1532-2092
Publisher: Oxford University Press
DOI: 10.1093/europace/euab200

Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study

Author(s): Susanna C. Larsson, Amy M. Mason, Siddhartha Kar, Mathew Vithayathil, Paul Carter, John A. Baron, Karl Michaëlsson, Stephen Burgess
Published in: BMC Medicine, 2020, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-020-01839-9

CODE-EHR best practice framework for the use of structured electronic healthcare records in clinical research

Author(s): Dipak Kotecha, Folkert W Asselbergs, Stephan Achenbach, Stefan D Anker, Dan Atar, Colin Baigent, Amitava Banerjee, Birgit Beger, Gunnar Brobert, Barbara Casadei, Cinzia Ceccarelli, Martin R Cowie, Filippo Crea, Maureen Cronin, Spiros Denaxas, Andrea Derix, Donna Fitzsimons, Martin Fredriksson, Chris P Gale, Georgios V Gkoutos, Wim Goettsch, Harry Hemingway, Martin Ingvar, Adrian Jonas, Robert Kazm
Published in: BMJ, 2022, ISSN 1756-1833
Publisher: BMJ Publishing Group
DOI: 10.1136/bmj-2021-069048

Self-palpation for detection of paroxysmal atrial fibrillation: Much noise with little signal

Author(s): Kazem Rahimi,Paulus Kirchhof
Published in: PLOS Medicine, 2020, ISSN 1549-1277
Publisher: Public Library of Science
DOI: 10.1371/journal.pmed.1003098

Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: The Hamburg City Health Study COVID programme

Author(s): Elina Larissa Petersen, Alina Goßling, Gerhard Adam, Martin Aepfelbacher, Christian-Alexander Behrendt, Ersin Cavus, Bastian Cheng, Nicole Fischer, Jürgen Gallinat, Simone Kühn, Christian Gerloff, Uwe Koch-Gromus, Martin Härter, Uta Hanning, Tobias B. Huber, Stefan Kluge, Johannes K. Knobloch, Piotr Kuta, Christian Schmidt-Lauber, Marc Lütgehetmann, Christina Magnussen, Carola Mayer, Kai Muel
Published in: European Heart Journal, 2022, ISSN 0195-668X
Publisher: Oxford University Press
DOI: 10.1093/eurheartj/ehab914