Objective
This project is aimed at a better understanding, diagnosis and treatment orientation of allergy, a disease undergoing explosive and worrisome progress. The team will design a new, miniature and automated multicriteria platform for separating allergens from food and/or environmental samples, and for detecting their allergenic activities on patient antibodies immobilised on anti-IgE and anti IgG4 strips. The project proposes a dramatic renewal of protein separation conventional schemes, by combining isoelectr ic focusing with a novel second dimension electrophoresis preserving the native, active structure of the proteins. This paradigmatic change will be associated with the power of newly developed microfluidic (lab-on-chip) systems, and with a new sensitive el ectrochemical method for the measurement of label free affinity sensograms, to allow automated and quantitative multicriteria screening. In contrast with current screening methods for allergy, which search for the response of a patient's serum to a limite d predefined set of known allergens, the approach developed in this project aims at screening the COMPLETE SET of potential allergens contained in a whole food extract (or more generally in any sample relevant to the patient's environment) against the pati ent's IgE and IgG4, WITHOUT ANY A PRIORI LIMITATION, and to identify the nature of the captured immunogens. Thus, besides strong innovation in the methodology of protein separation, the project proposes a radical enhancement in the power of allergen screen ing, with considerable potential for research, diagnosis and treatment follow-up of allergy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology other engineering and technologies microtechnology lab on a chip
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine allergology
- natural sciences chemical sciences electrochemistry electrophoresis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-NEST-B-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.