Objectif The aim of this project is to develop a method for characterization of the structure and dynamics of polycrystals on length scales from the atomic-level to that of the sample. The method, TotalCryst, determines the atomic arrangement within each grain as w ell as the 3D position and morphology of the grains.The structure of each grain can be solved and refined with accuracy presently obtainable only by studies of large single crystals. The method applies to inorganic structures as well as macromolecules and probes grains on all length scales from 100 nm to 1 mm. In this project it will be applied to studies within:Chemistry: TotalCryst will enable the identification and structural quantification of numerous complex or dilute structures which cannot be characterized by present methods. The method may find a widespread use in the pharmaceutical industry.Firstly, it accelerates the process of structure determination, a bottleneck in the process of registration of a new drug. Secondly, it enables characterization of drug content, polymorphism and homogeneity in tablets. Structural biology: Attempting to solve ever-larger structures, crystal quality and radiation sensitivity are major concerns. TotalCryst is a novel strategy for overcoming these issues.Time-resolved studies: TotalCryst offers a number of attractive and unique properties making it highly suitable for time-resolved studies. This includes conventional dynamic studies with time constants of the order of seconds as well as studies in the nano- to femt o-second regime based on stroboscopic methods involving a laser pump / X-ray probe scheme.An example is the possibility to, for the first time, study photo-sensitive materials, e.g. photoactive switches for photovoltaic devices and pigments. The consortium comprises a group of crystallographers, X-ray physicists and computer scientists as well as experts in pharmacy, structural biology and time-resolved studies. Champ scientifique agricultural sciencesagriculture, forestry, and fisheriesagriculturegrains and oilseedsnatural sciencesearth and related environmental sciencesgeologymineralogycrystallographymedical and health sciencesbasic medicinepharmacology and pharmacynatural sciencesbiological sciencesmolecular biologystructural biologynatural sciencesphysical sciencesopticslaser physics Mots‑clés Structural biology photochemistry time-resolved diffraction Programme(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) NEST-2003-1 - Adventure activities Appel à propositions FP6-2003-NEST-B-3 Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur DANMARKS TEKNISKE UNIVERSITET (TECHNICAL UNIVERSITY OF DENMARK) Contribution de l’UE Aucune donnée Adresse Anker Engelunds Vej 1 KGS. LYNGBY Danemark Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire FORSKNINGSCENTER RISØ - RISØ NATIONAL LABORATORY Danemark Contribution de l’UE Aucune donnée Adresse Frederiksborgvej 399 ROSKILDE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée FYZIKALNIUSTAV AV CR Tchéquie Contribution de l’UE Aucune donnée Adresse Na Slovance 2 PRAGUE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée INSTALLATION EUROPÉENNE DE RAYONNEMENT SYNCHROTRON France Contribution de l’UE Aucune donnée Adresse 6, rue Jules Horowitz GRENOBLE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Allemagne Contribution de l’UE Aucune donnée Adresse Hofgartenstrasse 8 MUENCHEN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée NOVO NORDISK A/S Danemark Contribution de l’UE Aucune donnée Adresse Novo Alle 1 BAGSVÆRD Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Royaume-Uni Contribution de l’UE Aucune donnée Adresse University Offices, Wellington Square OXFORD Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée THE GRADUATE CENTER OF THE CITY UNIVERSITY OF NEW YORK États-Unis Contribution de l’UE Aucune donnée Adresse 365 Fifth Avenue NEW YORK, NY Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée
