Objective
Recent technological advances have greatly increased the capability to investigate complex molecular interactions that occur in the onset of disease in order to identify genetic alterations and to screen new drugs.The first critical step of the drug deve lopment process is the identification and the validation of drug targets for the therapeutic application. At present about 500 molecular targets have been identified and validated.This is the basis of putative drug molecules that are able to interact wit h such targets.Recent advances have greatly speeded up the screening of the new drugs, however the number of resulting molecules which are not pharmacologically active is still extremely large. The optimisation of screening depends on the integration of in silico and in vitro analyses. The screening of targets is extreme difficult for multifactorial diseases, which are characterized by complex synergies between genetic and environmental factors.Cardiovascular diseases (CAD) are one of the major group of multifactorial diseases and are one the main causes of mortality and morbidity in most developed countries. The aim of this project is to discover new factors involved in atherogenesis and their related CAD and set up systems to select and test molecules that are pharmacologically active for the treatment of CAD.The project combines the computational (bioinformatics,cheminformatics and bioengineering) and the experimental (clinical medicine and biology) expertise.Clinical information drives bioinformati cs analysis.The results are the basic knowledge for cheminformatic analysis. Subsequently putative targets will be synthetised by industrial partner and tested on specific experimental models. These information,combined with physiological parameters, are used for the development of an in silico disease. A GRID infrastructure will be used to screen potential drug candidates. In addition,the project will provide a specialized portal for CAD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- social sciences sociology demography mortality
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GENOVA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.