Objective
Cardiac arrhythmia is a major cause of morbidity and mortality in Europe and of growing socio-economic concern. Recent data suggest that novel mechanisms such as HCN channels, mechanical effects on Ca handling and ion flux balances, and cellular heterogeneity may trigger and/or permit the sustenance of arrhythmias. The novelty of our approach is to focus on these potentially crucial, but ill-investigated, mechanisms by uniting 8 leading labs from 5EU countries who focus on individual arrhythmogenic aspects, in a bid to combine their expertise and shed light on how physiological or compensatory mechanisms may turn arrhythmogenic, and how this may be controlled or corrected.
Prime targets are structured along three levels of functional integration:
-Membrane level: Role of HCN channels in the generation of normal and abnormal rhythm
-Cellular level: Role of electro-mechanical interaction in modulating contractile activity and electrophysiology
-Multicellular level: Role of heterogeneity in normal and remodelled tissue on electrical excitation and conduction
Scientific and technological objectives:
-To develop suitable experimental tools, including HCN transgenic mice, novel bradycardic and antiarrhythmic agents, control of mechano-electrical interactions, and the symbiosis of the above
-To acquire new knowledge on molecular mechanisms and pathways controlling generation and spread of excitation in normal and diseased cardiac tissue
-To combine advanced engineering techniques for 'top-down' development of novel experimental tools with mathematical 'bottom-up' integration of data from the molecular level to fundamental and clinical relevance
Based on the combination of skills and techniques not currently available in any single lab worldwide, we will provide novel insight into novel arrhythmogenic mechanisms, quantify their interrelation, target preventive and therapeutic interventions to reduce the societal and economical impact of cardiac arrhythmia
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine cardiology cardiovascular diseases cardiac arrhythmia
- social sciences sociology demography mortality
- natural sciences chemical sciences inorganic chemistry alkali metals
- medical and health sciences basic medicine physiology
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
FIRENZE
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.