Objective
Mobile DNA provides a major contribution to the spread of antimicrobial resistance, by recruiting new resistance genes in bacterial pathogens and facilitating their horizontal spread. While much is known about individual resistance genes and mechanisms, the nature of the mobile elements and their transfer mechanisms have been clarified only in few cases, and very little is known about their molecular epidemiology. A comprehensive understanding of these aspects could provide a significant breakthrough toward combating dissemination of resistance determinants.
The DRESP project aims at investigating these aspects, focussing on few major families of genetic elements that carry a number of important and emerging resistance determinants: i) the double resolvase elements (DR-elements) of gram-positive cocci, involved in spread of mefA genes; ii) the related DR-elements in Gram-negative cocci, an entirely novel type of mobile element; iii) the vanA and mefE conjugative transposons; iv) the integrons; and (v) resistance plasmids.
The GENERAL OBJECTIVES of DRESP are: a) to investigate the molecular epidemiology and metagenomics of selected families of mobile elements in clinical strain collections and environmental samples; b) to carry out structural and functional analysis of these genetic elements to elucidate transfer mechanisms and their regulation, and to identify possible common molecular themes underlying these functions; c) to promote Information-Sharing and dialogue to stakeholders as to increase the social value and impact on pubic health of the knowledge gained.
EXPECTED DELIVERABLES of this project are: (i) new information on the spread of mobile elements carrying resistance genes, and mechanisms thereof; (ii) new techniques for molecular epidemiology studies; (iii) novel diagnostic tools; (iv) theoretical schemes for prediction of the potential spread of resistance to specific drugs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences health sciences public health epidemiology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SIENA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.