Objective
Considerable effort has been devoted to the development of gene delivery strategies for the treatment of inherited and aquired disorders in humans. Ex vivo gene therapies are based on removing cells from a patient, introducing a therapeutic gene construct into the cells, and implanting the engineered cells back into the patient. Currently, both viral and non-viral methods are used for gene delivery. Viral vectors are efficient in gene transfer, but their use raises serious safety concerns. Non-viral methods are usually safer but less efficient in providing long-term therapeutic transgene expression. Transposable elements can be considered as natural, non-viral delivery vehicles capable of efficient genomic insertion.
In this project, novel gene transfer technologies will be established by developing transposon vectors that mediate efficient and targeted integration of therapeutic genes into the genome. Therapeutic gene constructs will be made in transposon vectors, and delivered into cells ex vivo, using cutting edge non-viral nucleic acid delivery methods. Application of reversible implantation systems (collagen implants, skin biopumps, and encapsulated cells) will be explored. Animal disease models will include copper metabolism diseases, anemia, hypercholesterolemia, bleeding disorders, chronic grnulomatous disease and neurological disorders. Genomic insertion, transgene expression and phenotypic correction will be investigated. Safety issues of transposon vector administration and genomic integration will be addressed. The involvement of three SMEs will mobilise industrial know-how and technology. This project will develop, test and apply new therapeutic tools for somatic gene therapy as an alternative to currently used viral and non-viral technologies, and will have the potential to offer new solutions for diseases that impose significant impairment to citizens' quality of life, as well as burdens on health care services in Europe...
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences clinical medicine hematology
- medical and health sciences medical biotechnology implants
- medical and health sciences basic medicine neurology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BERLIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.