Project description
Pet immunotherapy
Due to the adaptation of pets to the human lifestyle, dogs and cats develop diseases similar to those of their owners. These include chronic inflammatory diseases and cancer. Inflammatory bowel disease (IBD) is one of the most devastating and common forms of chronic inflammation. Severe symptoms not only cause great pain to the four-legged patient, but also represent a significant burden for the pet owner. Similar diseases known from humans, such as Crohn's disease and ulcerative colitis, can be treated very efficiently with therapeutic antibodies. The CAESAR IBD Project, funded by the European Innovation Council, is developing species-specific therapeutic antibody solutions for the treatment of IBD in dogs, using the CAESAR proprietary phage display library developed by ADIVO.
Objective
Inflammatory bowel disease (IBD) in dogs is a common but poorly managed chronic condition causing immense emotional and financial distress to pet owners. Based on the positive results of antibodies to treat IBD in humans they have been proposed for dogs. However, instead of investigating a new drug specific for them some antibodies developed for other purposes and species has been adapted (petization), which can trigger immune responses in pets, yielding ineffective therapies and causing further health complications. At Adivo we have developed and validated CAESAR platform, which is the first fully canine phage-display library to generate therapeutic antibodies specific for dogs overcoming the limitations of current petization techniques. Now we aim to use this technology to develop and validate an effective drug to treat IBD in dogs. This project will bring a cumulative profit of 41 M in the first five years of commercialization, an ROI of 14 and to hire over 15 professionals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- agricultural sciences animal and dairy science domestic animals
- medical and health sciences basic medicine immunology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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HORIZON.3.1.2 - The Accelerator
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended Finance
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2021-ACCELERATOROPEN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
82152 Planegg
Germany
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.