Fighting Large-Scale Untreated Infectious Diseases with Innovative Treatments

Informations projet

FLUIDITY

N° de convention de subvention: 190144923

DOI

10.3030/190144923

Projet clôturé

Date de signature de la CE 20 Decembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2024

Financé au titre de

• The European Innovation Council (EIC)

Coût total

€ 4 582 237,50

Contribution de l’UE

€ 2 500 000,00

Coordonné par

MELETIOS THERAPEUTICS
France

Periodic Reporting for period 2 - FLUIDITY (Fighting Large-Scale Untreated Infectious Diseases with Innovative Treatments)

Période du rapport: 2024-01-01 au 2024-12-31

Résumé du contexte et des objectifs généraux du projet

The COVID-19 pandemic highlighted the unmet medical need for new antivirals that can help tackle existing and emerging viral infections. Funded by the European Innovation Council, the FLUIDITY project proposed to develop an innovative oral small molecule that limit internalisation and intracellular trafficking of viruses. The underlying concept is based on interfering with host membrane fluidity, which is beneficial as it has a broad-spectrum effect against multiple viruses. The molecule has also demonstrated an immunomodulatory effect, avoiding the immune system to react excessively after infection. As human safety is validated, the project was to perform a human proof of concept.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

Work on Fluidity is now stopped. The API batch for the clinical trial is available, the clinical trial design is defined, first contacts with potential partners have begun.
Next main part of the project was to run the clinical trial and generate the first results in humans. Unfortunately, due to lack of funding, the project is discontinued

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

Results of the clinical trial are not available yet as clinical trial is not completed