Fighting Large-Scale Untreated Infectious Diseases with Innovative Treatments

Projektinformationen

FLUIDITY

ID Finanzhilfevereinbarung: 190144923

DOI

10.3030/190144923

Projekt abgeschlossen

EK-Unterschriftsdatum 20 Dezember 2022

Startdatum 1 Januar 2023

Enddatum 31 Dezember 2024

Finanziert unter

• The European Innovation Council (EIC)

Gesamtkosten

€ 4 582 237,50

EU-Beitrag

€ 2 500 000,00

Koordiniert durch

MELETIOS THERAPEUTICS
France

Periodic Reporting for period 2 - FLUIDITY (Fighting Large-Scale Untreated Infectious Diseases with Innovative Treatments)

Berichtszeitraum: 2024-01-01 bis 2024-12-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

The COVID-19 pandemic highlighted the unmet medical need for new antivirals that can help tackle existing and emerging viral infections. Funded by the European Innovation Council, the FLUIDITY project proposed to develop an innovative oral small molecule that limit internalisation and intracellular trafficking of viruses. The underlying concept is based on interfering with host membrane fluidity, which is beneficial as it has a broad-spectrum effect against multiple viruses. The molecule has also demonstrated an immunomodulatory effect, avoiding the immune system to react excessively after infection. As human safety is validated, the project was to perform a human proof of concept.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

Work on Fluidity is now stopped. The API batch for the clinical trial is available, the clinical trial design is defined, first contacts with potential partners have begun.
Next main part of the project was to run the clinical trial and generate the first results in humans. Unfortunately, due to lack of funding, the project is discontinued

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

Results of the clinical trial are not available yet as clinical trial is not completed