Project description
Innovative heart valve replacement
Millions worldwide suffer from mitral valve regurgitation, where blood leaks back into the heart's left atrium. Untreated, this valve dysfunction leads to heart failure and death. Due to the invasiveness of current therapies, fewer than 5 % of seriously ill patients receive treatment, underscoring the need for improved therapeutic strategies. Funded by the European Innovation Council, the Angelvalve Project AVVie has developed the Mitral Butterfly (MB) system, an innovative solution designed to restore proper valve function. The flexible hemi-valve MB, as a minimally invasive procedure, can be delivered through a catheter. A unique passive stabilisation concept without active trauma to the myocardium prevents the MB stent from migrating. Enhanced material memory allows the MB to self-expand upon release, requiring minimal manipulation during placement.
Objective
The Mitral butterfly implant is a posterior leaflet augmentation device which functions to prevent excessive posterior leaflet motion. The implant comprises a)a Nitinol frame designed to sit comfortably within the anatomy of the heart and to provide the overall structure of the implant,b)an artificial leaflet, in the form of a flexible mesh which serves to restrict the prolapsing leaflet and provide a surface for adequate coaptation, and c)a method of anchoring. The implant can be folded into a catheter to facilitate delivery and be deployed in the target region with minimal actuation. The shape memory capabilities of nitinol allow the implant to self-expand when released, and the design of the frame ensures the correct orientation within the valve, consequently, the procedure involves minimal actuated steps with the main mechanical complexity arising from the anchorage. The anchorage itself is achieved with a secondary self-expanding nitinol mechanism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesbasic medicineanatomy and morphology
- medical and health sciencesmedical biotechnologyimplants
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Programme(s)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Funding Scheme
HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended FinanceCoordinator
1090 Wien
Austria
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.