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Fighting Aneurysmal Diseases

Objective

Fighting Aneurysmal Diseases (FAD) is a public health in EU, because of the ageing population. In the absence of intervention, aneurysms evolve towards rupture and death. The translational objectives of the project are to accelerate the acquisition of knowledge, and to develop new diagnostic and therapeutic tools for FAD in humans. The project innovates by integrating two different localizations differing in their initial etiologies but similar in their evolution. FAD will be built by pooling existing and new clinical & biological databases in EU. Tissue and cell banks will be constituted. The deliverables will be the standardization of clinical and biological procedures and the recording of all the material available in the consortium. These databases will provide a basis for genetic studies. Pathophysiology of aneurysms will be explored through human tissue and experimental models in transgenic animals, focusing on the role of proteases and their source within diseased tissues. Human databases, genetic & pathophysiological concepts will provide basis for the development of new diagnostic tools: genetic screening, identification of new surrogate markers, validation of candidate markers and discovery of new ones by proteomic approaches; and functional imaging, visualizing in situ various biological activities. These new molecules/cells of interest will be targeted in preclinical therapeutic approaches, using animal models, and by developing clinical trials. The objective of FAD will be achieved through the organization of a consortium, grouping 15 partners, integrating numerous medical and scientific disciplines. The consortium includes academic partners from 10 different EU countries, a Turkish research team, and 3 industrial partners. The acquired scientific and technological knowledges will be disseminated through training sessions, participation in European meetings, communication toward industry, and direct relationships with patient associations.

Field of science

  • /natural sciences/computer and information sciences/databases
  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/basic medicine/physiology/pathophysiology

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 900 960
Administrative Contact
Dina Ramamonjisoa (Ms.)

Participants (14)

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 582 000
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susan Mcpheat (Ms.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 703 000
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Saskia Vanden Broeck (Ms.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 1 354 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christina Hadders-Medin (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 562 000
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräessdorf (Ms.)
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Belgium
EU contribution
€ 773 000
Address
Sart Tilman B35
4000 Liege
Activity type
Research Organisations
Administrative Contact
Pol Louis (Mr.)
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 372 000
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mª Carmen Puerta (Ms.)
REGION MIDTJYLLAND
Denmark
EU contribution
€ 1 003 000
Address
Skottenborg 26
8800 Viborg
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Bent Christensen (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 652 000
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Louis Avigdor (Mr.)
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 352 000
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vladislav Treska (Prof.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 251 000
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lieve Peeters (Ms.)
PHARMALEADS SAS
France
EU contribution
€ 878 976
Address
Rue Watt, Immeuble Paris Biopark 11
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Pierre Rogala (Mr.)
TECHNOCLONE HERSTELLUNG DIAGNOSTIKAUND ARZNEIMITTELN GMBH
Austria
EU contribution
€ 372 000
Address
Brunnerstrasse 59/5
1230 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Veronika Binder (Ms.)
ISLENSK ERFDAGREINING EHF
Iceland
EU contribution
€ 953 000
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gudmundur Einarsson (Mr.)
TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU
Turkey
EU contribution
€ 291 000
Address
Ataturk Bulvari 221
06100 Ankara
Activity type
Research Organisations
Administrative Contact
Kemal Baysal (Prof.)