Objective Fighting Aneurysmal Diseases (FAD) is a public health in EU, because of the ageing population. In the absence of intervention, aneurysms evolve towards rupture and death. The translational objectives of the project are to accelerate the acquisition of knowledge, and to develop new diagnostic and therapeutic tools for FAD in humans. The project innovates by integrating two different localizations differing in their initial etiologies but similar in their evolution. FAD will be built by pooling existing and new clinical & biological databases in EU. Tissue and cell banks will be constituted. The deliverables will be the standardization of clinical and biological procedures and the recording of all the material available in the consortium. These databases will provide a basis for genetic studies. Pathophysiology of aneurysms will be explored through human tissue and experimental models in transgenic animals, focusing on the role of proteases and their source within diseased tissues. Human databases, genetic & pathophysiological concepts will provide basis for the development of new diagnostic tools: genetic screening, identification of new surrogate markers, validation of candidate markers and discovery of new ones by proteomic approaches; and functional imaging, visualizing in situ various biological activities. These new molecules/cells of interest will be targeted in preclinical therapeutic approaches, using animal models, and by developing clinical trials. The objective of FAD will be achieved through the organization of a consortium, grouping 15 partners, integrating numerous medical and scientific disciplines. The consortium includes academic partners from 10 different EU countries, a Turkish research team, and 3 industrial partners. The acquired scientific and technological knowledges will be disseminated through training sessions, participation in European meetings, communication toward industry, and direct relationships with patient associations. Fields of science medical and health scienceshealth sciencespublic healthnatural sciencescomputer and information sciencesdatabasesmedical and health sciencesclinical medicineangiologyvascular diseasesmedical and health sciencesbasic medicinephysiologypathophysiology Keywords aorta diagnosis experimental model genomic human database proteomic therapeutic Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.2-2 - Vascular remodelling in aneurysmal disease Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Address Rue de tolbiac 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Dina Ramamonjisoa (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 900 960,00 Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all ST GEORGE'S HOSPITAL MEDICAL SCHOOL United Kingdom EU contribution € 582 000,00 Address Cranmer terrace SW17 0RE London See on map Region London Inner London — West Wandsworth Activity type Higher or Secondary Education Establishments Administrative Contact Susan Mcpheat (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITEIT GENT Belgium EU contribution € 703 000,00 Address Sint pietersnieuwstraat 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Administrative Contact Saskia Vanden Broeck (Ms.) Links Contact the organisation Opens in new window Website Opens in new window KAROLINSKA INSTITUTET Sweden EU contribution € 1 354 000,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Christina Hadders-Medin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 562 000,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fräessdorf (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE Belgium EU contribution € 773 000,00 Address Avenue de l hopital 1 4000 Liege See on map Region Région wallonne Prov. Liège Arr. Liège Activity type Research Organisations Administrative Contact Pol Louis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDAD AUTONOMA DE MADRID Spain EU contribution € 372 000,00 Address Calle einstein 3 ciudad univ cantoblanco rectorado 28049 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Administrative Contact Mª Carmen Puerta (Ms.) Links Contact the organisation Opens in new window Website Opens in new window REGION MIDTJYLLAND Denmark EU contribution € 1 003 000,00 Address Skottenborg 26 8800 Viborg See on map Region Danmark Midtjylland Vestjylland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Bent Christensen (Mr.) Links Contact the organisation Opens in new window CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 652 000,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Louis Avigdor (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERZITA KARLOVA Czechia EU contribution € 352 000,00 Address Ovocny trh 560/5 116 36 Praha 1 See on map Region Česko Praha Hlavní město Praha Activity type Higher or Secondary Education Establishments Administrative Contact Vladislav Treska (Prof.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 251 000,00 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Lieve Peeters (Ms.) Links Contact the organisation Opens in new window Website Opens in new window PHARMALEADS SAS France EU contribution € 878 976,00 Address Rue watt, immeuble paris biopark 11 75013 Paris See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jean-Pierre Rogala (Mr.) Links Contact the organisation Opens in new window Website Opens in new window TECHNOCLONE HERSTELLUNG DIAGNOSTIKAUND ARZNEIMITTELN GMBH Austria EU contribution € 372 000,00 Address Brunnerstrasse 59/5 1230 Wien See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Veronika Binder (Ms.) Links Contact the organisation Opens in new window Website Opens in new window ISLENSK ERFDAGREINING EHF Iceland EU contribution € 953 000,00 Address Sturlugotu 8 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gudmundur Einarsson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU Türkiye EU contribution € 291 000,00 Address Ataturk bulvari 221 06100 Ankara See on map Activity type Research Organisations Administrative Contact Kemal Baysal (Prof.) Links Contact the organisation Opens in new window Website Opens in new window
