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Translational Research in Europe – Applied Technologies for Osteoarthritis

Objetivo

TREAT-OA will address the need for better treatment and diagnostics for osteoarthritis (OA) - the most common cause of disability in Europe. Currently there are no drugs that can cure, reverse or halt the disease. Nor are there yet reliable clinical biochemical markers for diagnosis or prognosis which is an impediment to the management of OA, costs of therapeutic trials and the development of disease modifying drugs. TREAT-OA represents a large-scale collaborative, integrated, trans-disciplinary project utilising a resource of 28,000 OA phenotyped subjects with available genome-wide association scan data as well as leading basic science laboratories and technologies. This is the largest study of its kind that will address the generalisability and utility of genetic and biochemical risk factors throughout the EU. The key objectives of TREAT-OA are to: 1 Identify genes and biochemical markers consistently associated with risk and progression of OA 2 Use such genes to further our understanding of the molecular pathways involved in disease aetiology 3 Analyze pathways to identify targets for pharmacological intervention 4 Develop transgenic animal laboratory OA model systems . 5 Develop a panel of genetic and biochemical diagnostics for risk and progression of OA 6 Disseminate results from this extensive research at large and use results and technologies for training within the EU TREAT-OA will help develop European clinical and scientific excellence in the diagnosis and treatment of OA. The novel pathways in disease aetiology discovered will translate into novel drug targets and protein therapeutics for OA. The development of in vitro and in vivo assays will provide a comprehensive technology platform enabling the discovery and development of disease modifying drugs for OA. TREAT-OA will also make a major impact on the disease via a diagnostic panel of genes and biochemical markers for selecting severe cases and rapidly progressing individuals.

Convocatoria de propuestas

FP7-HEALTH-2007-A
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Coordinador

KING'S COLLEGE LONDON
Dirección
Strand
WC2R 2LS London
United Kingdom
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 3 113 787,90
Contacto administrativo
Paul Labbett (Mr.)

Participantes (10)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Aportación de la UE
€ 1 635 910,40
Dirección
Wellington Square University Offices
OX1 2JD Oxford
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Edward Gibbs (Mr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Países Bajos
Aportación de la UE
€ 513 900
Dirección
Dr Molewaterplein 40
3015 GD Rotterdam
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Jan Willem Te Ronde (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Países Bajos
Aportación de la UE
€ 821 946,75
Dirección
Albinusdreef 2
2333 ZA Leiden
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Liesbeth Dorama (Ms.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Bélgica
Aportación de la UE
€ 1 673 700
Dirección
Oude Markt 13
3000 Leuven
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Maria Vereeken (Ms.)
SYNARC SAS
Francia
Aportación de la UE
€ 999 275
Dirección
Rue De Montbrillant 16
69003 Lyon
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Patrick Garnero (Dr.)
TIGENIX NV

La participación finalizó

Bélgica
Aportación de la UE
€ 628 036,95
Dirección
Romeinse Straat 12/2 Research Park Haasrode 1724
3001 Leuven
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Luc Dochez (Mr.)
PANEPISTIMIO IOANNINON
Greece
Aportación de la UE
€ 474 780
Dirección
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
George Papageorgiou (Prof.)
ISLENSK ERFDAGREINING EHF
Islandia
Aportación de la UE
€ 935 720
Dirección
Sturlugotu 8
101 Reykjavik
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Gudmundur Einarsson (Mr.)
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Países Bajos
Aportación de la UE
€ 539 740
Dirección
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Tipo de actividad
Other
Contacto administrativo
Don Van Velzen (Mr.)
ARCARIOS
Bélgica
Aportación de la UE
€ 587 863
Dirección
Agoralaan A Bis
3590 Diepenbeek
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Guido Maertens (Mr.)