Objectif
The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.
Mots‑clés
Appel à propositions
FP7-HEALTH-2007-A
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Régime de financement
CP-IP - Large-scale integrating projectCoordinateur
78464 Konstanz
Allemagne
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Participants (27)
73728 ESSLINGEN
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28029 Madrid
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Participation terminée
2333CR LEIDEN
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3015 GD Rotterdam
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5000 Namur
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Participation terminée
SW7 2AZ LONDON
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1010 Wien
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60124 Ancona
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1800 VEVEY
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11635 Athina
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02 093 Warszawa
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11241 BUCHAREST
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3721 MA Bilthoven
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5032 Gembloux Les Isnes
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8000 Aarhus C
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B4 7ET Birmingham
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9052 ZWIJNAARDE - GENT
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70599 Stuttgart
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6108 Halle
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40126 Bologna
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EC4Y 0DY LONDON
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00185 Roma
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75252 PARIS
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2333 ZA Leiden
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33014 TAMPERE
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MK43 0AL Cranfield - Bedfordshire
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6020 Innsbruck
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