Cel
The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project participants. Bioinformatics will be used in order to extract a robust set of biomarkers of human ageing from the large amounts of data to be generated and to derive a model for healthy ageing.
Słowa kluczowe
Zaproszenie do składania wniosków
FP7-HEALTH-2007-A
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
CP-IP - Large-scale integrating projectKoordynator
78464 Konstanz
Niemcy
Zobacz na mapie
Uczestnicy (27)
73728 ESSLINGEN
Zobacz na mapie
28029 Madrid
Zobacz na mapie
Zakończenie uczestnictwa
2333CR LEIDEN
Zobacz na mapie
3015 GD Rotterdam
Zobacz na mapie
5000 Namur
Zobacz na mapie
Zakończenie uczestnictwa
SW7 2AZ LONDON
Zobacz na mapie
1010 Wien
Zobacz na mapie
60124 Ancona
Zobacz na mapie
1800 VEVEY
Zobacz na mapie
11635 Athina
Zobacz na mapie
02 093 Warszawa
Zobacz na mapie
11241 BUCHAREST
Zobacz na mapie
3721 MA Bilthoven
Zobacz na mapie
5032 Gembloux Les Isnes
Zobacz na mapie
8000 Aarhus C
Zobacz na mapie
B4 7ET Birmingham
Zobacz na mapie
9052 ZWIJNAARDE - GENT
Zobacz na mapie
70599 Stuttgart
Zobacz na mapie
6108 Halle
Zobacz na mapie
40126 Bologna
Zobacz na mapie
EC4Y 0DY LONDON
Zobacz na mapie
00185 Roma
Zobacz na mapie
75252 PARIS
Zobacz na mapie
2333 ZA Leiden
Zobacz na mapie
33014 TAMPERE
Zobacz na mapie
MK43 0AL Cranfield - Bedfordshire
Zobacz na mapie
6020 Innsbruck
Zobacz na mapie