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TARGETING HIV INTEGRATION CO-FACTORS, TARGETING CELLULAR PROTEINS DURING NUCLEAR IMPORT OR INTEGRATION OF HIV

Objective

Standard therapy of infection with the human immunodeficiency virus type 1 (HIV-1) is based on potent cocktails of drugs targeting viral proteins. This treatment is associated with severe side effects and is almost unaffordable for the patients living in sub-Saharan Africa. Incomplete suppression of HIV replication results in drug-resistance. Therefore, a continued research effort is required to develop more potent, cheaper and less toxic antivirals. The insight has grown that HIV requires cellular proteins to serve as co-factors for viral replication. Our over-all objective is to develop novel drugs by targeting co-factors required for HIV replication. The virus will find it difficult to develop antiviral resistance against drugs targeting interaction between invariable cellular proteins and conserved viral protein domains. We will focus on the cellular proteins that mediate HIV trafficking, nuclear import and integration, such as Lens Epithelium Derived Growth Factor (LEDGF/p75), a novel cofactor of HIV-1 integration. THINC is composed of 3 virologists, 2 medicinal chemists, 1 virologist from South Africa, 1 structural biologist, 1 pharmaceutical company. Our first objective is to identify and validate novel co-factors of HIV trafficking, nuclear import and integration as novel targets for anti-HIV therapy. The second objective is to develop new drugs against the validated cellular target LEDGF/p75. The third objective is to perform this work in the perspective of those who will benefit most: the HIV infected people all over the world. The initial steps of target validation and hit identification will mainly be taken by academic groups, while optimization and (pre)clinical development of drugs requires the participation of Tibotec, a European company devoted to the development of antiviral drugs. The project will also increase our generic understanding of protein-protein interactions (PPI).

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 894 733,72
Administrative Contact
Marleen Verlinden (Ms.)

Participants (10)

SCUOLA NORMALE SUPERIORE

Participation ended

Italy
EU contribution
€ 228 549,95
Address
Piazza Dei Cavalieri 7
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beatrice Semzaconi (Dr.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 352 002
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Massimo Ferri (Prof.)
UNIVERSITA DEGLI STUDI DI MESSINA
Italy
EU contribution
€ 285 200
Address
Piazza Pugliatti 1
98122 Messina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Antonella Cocchiara (Prof.)
TIBOTECH PHARMACEUTICALS LTD

Participation ended

Ireland
Address
East Gate Village
- Little Island - Cork
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Leo Versteynen (Ms.)
UNIVERSITY OF KWAZULU-NATAL
South Africa
EU contribution
€ 226 505
Address
University Road, Chiltern Hills
3630 Westville
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paulina Motshehoa Mokotedi (Prof.)
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
Czechia
EU contribution
€ 227 600
Address
Flemingovo Nam. 542/2
16610 Praha 6
Activity type
Research Organisations
Administrative Contact
Renata Sroglova (Ms.)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 404 600
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alex Waehry (Ms.)
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
EU contribution
€ 66 000
Address
Piazza Dell Universita 1
06123 Perugia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Bistoni (Prof.)
JANSSEN INFECTIOUS DISEASES DIAGNOSTICS BVBA

Participation ended

Belgium
EU contribution
€ 72 881,44
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Leo Versteynen (Ms.)
UNIVERSITA DEGLI STUDI DI TRENTO
Italy
EU contribution
€ 181 599,89
Address
Via Calepina 14
38122 Trento
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vanessa Ravagni (Dr.)