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Paediatric European Network Treatment AIDS Laboratory Network (PENTA LABNET)

Objective

PENTA-LABNET(PL) is a coordination action aimed at improving the range of products and clinical use of antiretrovirals(ARVs) in HIV-infected children in resource-rich and resource-limited countries. This will be achieved through building capacity of laboratories to undertake co-ordinated studies on pharmacokinetics, pharmacodynamics and pharmacogenetics of new formulations and dosing and studies of viral and immune responses to novel regimens and strategies for using ARVs in children. PL forms a logical, necessary and cost-effective addition to the clinical-trial-focused research activities of the longstanding PENTA network, building on its existing operational infrastructures and expertise. To respond to emerging needs identified by EU as priority areas, the aim of PL is the development of a “drug centred” research platform, which will provide a complimentary range of activities focussed on supporting the rational selection of optimal dosage and delivery forms of ARVs, and providing the lab basis for evaluating new ARVs strategies in children. The definition, organisation and management of integrated pharmacological and viro/immunological studies to better characterise the concentration-exposure-effect relationship will be a central activity of PL. In support of these studies, standardised data collection systems will be established enabling linkage of clinical and laboratory data. In addition a central biobank will be set up to provide rapid identification of samples to be used for research. The laboratory and paediatric expertise generated in PL will support rapid assessment of new and existing individual and combined ARVs. The WHO will be a key partner of PL to define research priorities in ARV drug development and (also through PENTA’s extensive international links) to rapidly disseminate results to a range of stakeholders (e.g. EMEA and industries) and support the rapid translation of research findings into guidelines and practice for children in all settings

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmacokinetics

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CSA-CA - Coordination (or networking) actions

Coordinator

FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS
Address
Corso Stati Uniti 4
35127 Padova
Italy
Activity type
Research Organisations
EU contribution
€ 316 230
Administrative Contact
Silvia Faggion (Dr.)

Participants (11)

MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 58 620
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Richard Frost (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 21 310
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Audrey Laurent (Ms.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 73 780
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim W.A. Bruinenberg Mba (Mr.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 57 620
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colin Cooper (Mr.)
University College London
United Kingdom
EU contribution
€ 98 700
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kent Lee (Mr.)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 87 660
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ton Brouwer (Mr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 130 760
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Marie-Anne Fourrier (Ms.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 65 480
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donato Nitti (Prof.)
FONDAZIONE IRCCS POLICLINICO SAN MATTEO
Italy
EU contribution
€ 37 820
Address
Viale Golgi 19
27100 Pavia
Activity type
Research Organisations
Administrative Contact
Franco Marazza (Dr.)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
France
EU contribution
€ 31 820
Address
Boulevard De Dunkerque 44 Cs 90009
13572 Marseille
Activity type
Research Organisations
Administrative Contact
Hervé Michel (Mr.)
WORLD HEALTH ORGANIZATION
Switzerland
EU contribution
€ 20 200
Address
Avenue Appia 20
1211 Geneve
Activity type
Research Organisations
Administrative Contact
Anne Marie Worning (Dr.)