Objective PENTA-LABNET(PL) is a coordination action aimed at improving the range of products and clinical use of antiretrovirals(ARVs) in HIV-infected children in resource-rich and resource-limited countries. This will be achieved through building capacity of laboratories to undertake co-ordinated studies on pharmacokinetics, pharmacodynamics and pharmacogenetics of new formulations and dosing and studies of viral and immune responses to novel regimens and strategies for using ARVs in children. PL forms a logical, necessary and cost-effective addition to the clinical-trial-focused research activities of the longstanding PENTA network, building on its existing operational infrastructures and expertise. To respond to emerging needs identified by EU as priority areas, the aim of PL is the development of a “drug centred” research platform, which will provide a complimentary range of activities focussed on supporting the rational selection of optimal dosage and delivery forms of ARVs, and providing the lab basis for evaluating new ARVs strategies in children. The definition, organisation and management of integrated pharmacological and viro/immunological studies to better characterise the concentration-exposure-effect relationship will be a central activity of PL. In support of these studies, standardised data collection systems will be established enabling linkage of clinical and laboratory data. In addition a central biobank will be set up to provide rapid identification of samples to be used for research. The laboratory and paediatric expertise generated in PL will support rapid assessment of new and existing individual and combined ARVs. The WHO will be a key partner of PL to define research priorities in ARV drug development and (also through PENTA’s extensive international links) to rapidly disseminate results to a range of stakeholders (e.g. EMEA and industries) and support the rapid translation of research findings into guidelines and practice for children in all settings Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicineimmunologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmacokineticsmedical and health sciencesclinical medicinepaediatrics Keywords Coordination HIV/AIDs PENTA Paediatrics Pharamcokinetics Pharmacology Viroimmunology drug formulations formulations Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.3.2-5 - Paediatric formulations of drugs against HIV/AIDS, malaria and tuberculosis Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CSA-CA - Coordination (or networking) actions Coordinator FONDAZIONE PENTA ETS Address Corso stati uniti 4 35127 Padova Italy See on map Region Nord-Est Veneto Padova Activity type Research Organisations Administrative Contact Silvia Faggion (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 316 230,00 Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 58 620,00 Address 20 park crescent W1B 1AL London See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Richard Frost (Mr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 21 310,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Audrey Laurent (Ms.) Links Contact the organisation Opens in new window Website Opens in new window STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 73 780,00 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Wim W.A. Bruinenberg Mba (Mr.) Links Contact the organisation Opens in new window Website Opens in new window THE UNIVERSITY OF LIVERPOOL United Kingdom EU contribution € 57 620,00 Address Brownlow hill 765 foundation building L69 7ZX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Colin Cooper (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY COLLEGE LONDON United Kingdom EU contribution € 98 700,00 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Kent Lee (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITEIT LEIDEN Netherlands EU contribution € 87 660,00 Address Rapenburg 70 2311 EZ Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Ton Brouwer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 130 760,00 Address 55 boulevard diderot 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Marie-Anne Fourrier (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI PADOVA Italy EU contribution € 65 480,00 Address Via 8 febbraio 2 35122 Padova See on map Region Nord-Est Veneto Padova Activity type Higher or Secondary Education Establishments Administrative Contact Donato Nitti (Prof.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE IRCCS POLICLINICO SAN MATTEO Italy EU contribution € 37 820,00 Address Viale golgi 19 27100 Pavia See on map Region Nord-Ovest Lombardia Pavia Activity type Research Organisations Administrative Contact Franco Marazza (Dr.) Links Contact the organisation Opens in new window Website Opens in new window INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT France EU contribution € 31 820,00 Address Boulevard de dunkerque 44 cs 90009 13572 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Research Organisations Administrative Contact Hervé Michel (Mr.) Links Contact the organisation Opens in new window Website Opens in new window WORLD HEALTH ORGANIZATION Switzerland EU contribution € 20 200,00 Address Avenue appia 20 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Research Organisations Administrative Contact Anne Marie Worning (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
