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Neurobiological Mechanisms of Memory Loss in Alzheimer's Disease

Objetivo

The MEMOLOAD project will focus on the molecular and biological mechanisms underlying memory loss that occurs in Alzheimer’s disease, the leading cause of dementia and an enormous medical, social and economic challenge to Europe. Several lines of evidence point to accumulation of beta-amyloid peptide (Aß) in the brain as the key pathologic event in the disease. There is growing evidence that Aß causes memory loss by directly or directly interacting with the known key signalling pathways involved in memory consolidation. However, at present the data is fragmentary and consists mainly of single observations in particular models (cell culture, brain slice, in vivo). In most cases, we still lack the evidence that a clear molecular level interaction translates into memory impairment in vivo. The objective of this proposal is to elucidate the molecular level mechanisms by which accumulation of Aß in the brain results in impaired synaptic plasticity and memory loss. The MEMOLOAD consortium consists of a well-balanced mixture of the seven best available European research groups in terms of research experience on both the mechanisms of memory consolidation and the pathophysiology of Alzheimer’s disease. The current research topic is thus the primary research interest of all partners. MEMOLOAD will significantly contribute to a better understanding of brain memory mechanisms at the behavioural, network, synaptic and molecular levels and of dysfunction at all these levels in Alzheimer’s disease (AD). The knowledge acquired during the course of MEMOLOAD will translate into new validated in vitro and in vivo models for the memory impairing effect of Aß and will feed into industrial development leading to new therapies. The output of MEMOLOAD will include both identification of new drug targets and development of novel peptidomimetic compounds that neutralize the deleterious effects of most harmful Aß species.

Convocatoria de propuestas

FP7-HEALTH-2007-A
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Coordinador

ITA-SUOMEN YLIOPISTO
Dirección
Yliopistonranta 1 E
70211 Kuopio
Finlandia

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Heikki Tanila (Prof.)
Aportación de la UE
€ 593 356

Participantes (6)

SZEGEDI TUDOMANYEGYETEM
Hungría
Aportación de la UE
€ 396 358
Dirección
Dugonics Ter 13
6720 Szeged

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Botond Penke (Prof.)
KAROLINSKA INSTITUTET
Suecia
Aportación de la UE
€ 395 676
Dirección
Nobels Vag 5
17177 Stockholm

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Jill Blomstrand (Ms.)
RUHR-UNIVERSITAET BOCHUM
Alemania
Aportación de la UE
€ 396 358
Dirección
Universitaetsstrasse 150
44801 Bochum

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Melanie Brüngel-Dittrich (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Francia
Aportación de la UE
€ 424 352
Dirección
Rue Michel Ange 3
75794 Paris

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Tipo de actividad
Research Organisations
Contacto administrativo
Michèle Saumon (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
Aportación de la UE
€ 396 252
Dirección
Old College, South Bridge
EH8 9YL Edinburgh

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Angela Noble (Ms.)
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Irlanda
Aportación de la UE
€ 396 360
Dirección
College Green Trinity College
D02 CX56 Dublin 2

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Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Michael Rowan (Prof.)