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Investigation of the molecular pathogenesis and pathophysiology of Disorders of Sex Development (DSD)

Objective

Disorders of Sex Development (DSD) constitute a group of rare to very rare mostly heritable disorders affecting the genito-urinary tract and in most instances also the endocrine-reproductive system. We hypothesize that stringent and stepwise analysis of cases with DSD will result in a systematic and reliable discovery of DSD-relevant biochemical, genetic and functional profiles, allowing for the detection of new diagnostic markers, both in steroid biosynthesis as well as in genetics to provide the basis for explaining the nature of these disorders. Characterization of the functional aspects of androgen action as the main basis for sex-related phenotype will improve the understanding of the pathophysiology of DSD phenotypes. This will allow for better decision-making in gender assignment and therapeutic approaches to DSD as well as improve gender medicine in general.

Call for proposal

FP7-HEALTH-2007-A
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Coordinator

UNIVERSITAET zu LUEBECK
Address
Ratzeburger allee 160
23562 Lubeck
Germany

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Region
Schleswig-Holstein Schleswig-Holstein Lübeck, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christina Catana (Ms.)
Links
EU contribution
No data

Participants (13)