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Investigation of the molecular pathogenesis and pathophysiology of Disorders of Sex Development (DSD)

Objective

Disorders of Sex Development (DSD) constitute a group of rare to very rare mostly heritable disorders affecting the genito-urinary tract and in most instances also the endocrine-reproductive system. We hypothesize that stringent and stepwise analysis of cases with DSD will result in a systematic and reliable discovery of DSD-relevant biochemical, genetic and functional profiles, allowing for the detection of new diagnostic markers, both in steroid biosynthesis as well as in genetics to provide the basis for explaining the nature of these disorders. Characterization of the functional aspects of androgen action as the main basis for sex-related phenotype will improve the understanding of the pathophysiology of DSD phenotypes. This will allow for better decision-making in gender assignment and therapeutic approaches to DSD as well as improve gender medicine in general.

Field of science

  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /natural sciences/biological sciences/genetics and heredity

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITAET zu LUEBECK
Address
Ratzeburger Allee 160
23562 Lubeck
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 592 838
Administrative Contact
Christina Catana (Ms.)

Participants (13)

UNIVERSITY OF GLASGOW
United Kingdom
EU contribution
€ 250 392
Address
University Avenue
G12 8QQ Glasgow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joe Galloway (Mr.)
INSTITUT PASTEUR
France
EU contribution
€ 292 865
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 347 718
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dawn Barker (Ms.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 188 232
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Robert Fekete (Mr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 188 546
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
A.A. Steenbergen (Ms.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 72 200
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kent Lee (Mr.)
UNIVERSITA DI PISA
Italy
EU contribution
€ 17 000
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silvano Bertelloni (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 26 400
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Walstam (Mr.)
Westfälische Wilhelms-Universität Münster
Germany
EU contribution
€ 231 200
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karl-Heinz Runde (Mr.)
HOSPICES CIVILS DE LYON
France
EU contribution
€ 26 400
Address
Quai Des Celestins 3
69002 Lyon
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Yves Morel (Mr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG
Germany
EU contribution
€ 257 999
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 476 408
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingmar Schmidt (Dr.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 21 000
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margo Baele (Dr.)