Objective
Malaria in pregnancy has been recently prioritised by the EC 7th Framework Program. In response, we propose to carry out a cohort observational study in pregnant women in 5 P. vivax endemic countries, broadly representing most of the world's infections. The Indian and Papua New Guinean endemic sites are included because of their important contribution to the global burden of vivax malaria; PNG has a high prevalence of asymptomatic P. vivax infections resembling P. falciparum infection in sub-Saharan Africa, and India contributes to nearly 80% of malaria cases in Southeast Asia. In Latin America, 3 countries are selected, Guatemala, Colombia and Brazil. In Guatemala P vivax is responsible for almost all malaria cases, in Colombia and Brazil it co-exists in different proportions with falciparum. Pregnant women will be enrolled at each site during routine antenatal care visits (ANC) and followed-up at the health facility until delivery or end of pregnancy. P. vivax malaria parasitaemia will be assessed at enrolment, at every contact with the health facility and at delivery. In a sub-sample of women, peripheral blood will be taken for immunological/molecular studies, and placental samples will be collected. To assess with precision the prevalence of infection (estimated to be around 4% on average) and to obtain sufficient number of pregnant women with P vivax infection to determine the impact on birthweight, 2000 pregnant women per site will be enrolled. Due to the likely low prevalence of infection in pregnancy, the number of pregnant women with P. vivax per site will probably not be enough to assess specific impact for each site, thus a multicentric study design will be used. Immunological analysis will be performed to unveil whether there are pregnancy-specific immune responses. Phenotypic and genotypic analyses of parasites from the placenta should reveal their adhesive properties and whether the accumulation of infected erythrocytes unique parasite population.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine obstetrics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2007-A
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08036 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.