Objective The HYPERImage project will develop a novel hybrid system for simultaneous whole-body PET/MR imaging for humans. It will advance the required Time-of-Flight (ToF) PET technology, and the software for MR mediated compensation of motion artefacts. The hybrid system will be validated in pre-clinical and initial clinical studies, for exemplary applications in cardiovascular diseases, and in breast cancer as one of the most relevant applications in oncology. For latter application, the concept will be extended from pure imaging towards image-guided therapy. Positron Emission Tomography (PET) is the most sensitive molecular imaging modality. Hybrid PET/CT systems using Computer Tomography (CT) to provide the anatomical reference for lesion localization have evolved to be the best choice for a number of applications in cardiology and oncology. However, PET/CT has drawbacks and limitations: CT is associated with radiation dose and lacks soft tissue contrast, and PET suffers from restrictions in small lesion detectability, both due to motion artefacts during the scan, and due to detector limitations. A hybrid combination of ToF-PET with a 3T MR has the potential to overcome these shortcomings, by fully exploiting the superior soft-tissue contrast of MR in combination with a new MR-compatible solid-state PET detector technology, and a sophisticated motion compensation enabled by concurrent acquisition of both MR and time-stamped PET data. In addition, the versatility of MR allows imaging of supplementary functional parameters like temperature, elasticity, and diffusion, enabling this new hybrid imaging concept to open up new fields of applications in therapy guidance and therapy response monitoring. The consortium consists of one large company, one SME, three academic partners and two research institutes from five different EU countries. It combines leadership in technology with pioneer experience in using biomedical imaging for diagnosis and therapy monitoring. Fields of science natural sciencescomputer and information sciencessoftwaremedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesclinical medicinecardiologycardiovascular diseases Keywords CVD MRI PET attenuation correction cancer compensation attenuation concurrent imaging correction early detection cancer CVD early detection hybrid hybrid imaging imaging PET MRI silicon imaging concurrent motion compensation photomultiplier motion silicon silicon photomultiplier Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.2-1 - Development of a hybrid imaging system Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator PHILIPS TECHNOLOGIE GMBH Address Luebeckertordamm 5 20099 Hamburg Germany See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Keur (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 299 559,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all KING'S COLLEGE LONDON United Kingdom EU contribution € 658 254,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) Spain EU contribution € 249 202,00 Address Calle melchor fernandez almagro 3 28029 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Julia Redondo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands EU contribution € 663 840,00 Address Plesmanlaan 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri Van Luenen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Germany EU contribution € 220 480,00 Address Martinistrasse 52 20251 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Administrative Contact Michael Kaul (Mr.) Links Contact the organisation Opens in new window Website Opens in new window RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Germany EU contribution € 645 185,00 Address Seminarstrasse 2 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Norbert Huber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window IMINDS VZW Belgium EU contribution € 301 288,00 Address Gaston crommenlaan 8/102 9050 Gent See on map Activity type Research Organisations Administrative Contact Steven Staelens (Dr.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE BRUNO KESSLER Italy EU contribution € 902 192,00 Address Via santa croce 77 38122 Trento See on map Region Nord-Est Provincia Autonoma di Trento Trento Activity type Research Organisations Administrative Contact Umberto Silvestri (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
