Objective This proposal offers to combine X-ray CT (XCT) and Fluorescence Molecular Tomography (FMT) into a hybrid, quantitative system and method. The project builds on state-of the-art knowledge that only recently became available in different European states as represented by the partners herein. In return it delivers the first such hybrid system worldwide. The system will operate by 1) co-registering XCT images with highly performing FMT images for merging anatomical, functional and molecular contrast and by 2) combining XCT information into the FMT inversion to provide a system with superior imaging performance. XCT-based correction, as explained in this proposal, can improve FMT performance in a more radical way than corresponding “correction methods” used for improving PET or SPECT images. In this way FMT-XCT can reach the imaging accuracy of radio-nuclei-based tomography hybrid systems. By using fluorescence, FMT-XCT can then enable high flexibility in targeting physiology and molecular function, especially in multi-spectral mode, and high dissemination potential because virtually any biomedical laboratory has access to fluorescence reporting, compared to radio-nuclei based research that requires access to radiochemistry and cyclotron facilities. FMT-XCT aims in advancing small animal imaging and drug discovery with a view towards the clinical application on non-invasive breast cancer imaging. For this reason, focus herein is given to imaging breast cancer and response to therapy. Overall the technology is ideally suited for commercial translation and has the potential to become the method of choice for in-vivo imaging in most biomedical laboratories and in select clinical applications. While it appreciates the value of nuclear imaging methods, this proposal will hopefully raise the funding necessary to establish on European ground a new potent paradigm of in-vivo imaging with high dissemination and application potential and large social and health-care impact . Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesphysical sciencestheoretical physicsparticle physicsparticle acceleratornatural scienceschemical sciencesnuclear chemistryradiochemistrymedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesbasic medicinephysiology Keywords 360-degree Anatomical Functional and Molecular imaging Free-space Free-space 360-degree Fluorescence Tomography Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.2-1 - Development of a hybrid imaging system HEALTH-2007-1.2-2 - Novel optical methodologies for detection, diagnosis and monitoring of disease or disease-related processes Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH EU contribution € 1 294 102,00 Address INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg Germany See on map Region Bayern Oberbayern München, Landkreis Activity type Research Organisations Administrative Contact Juergen Ertel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 1 212 389,00 Address RUE LEBLANC 25 75015 PARIS 15 See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Olivier Leroy (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IDRYMA TECHNOLOGIAS KAI EREVNAS Greece EU contribution € 488 550,00 Address N PLASTIRA STR 100 70013 Irakleio See on map Region Νησιά Αιγαίου Κρήτη Ηράκλειο Activity type Research Organisations Administrative Contact Jorge Ripoll (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 409 600,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kent Lee (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON Participation ended Spain EU contribution € 350 602,56 Address CALLE DOCTOR ESQUERDO 46 28007 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Other Administrative Contact Jesús Maria Calavia Balduz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data University of Zurich Switzerland EU contribution € 365 600,00 Address RAMISTRASSE 71 8006 ZURICH See on map Activity type Higher or Secondary Education Establishments Administrative Contact Markus Rudin (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CT Imaging GmbH Germany EU contribution € 263 500,00 Address Henkestrasse, 91 91052 ERLANGEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mandy Landmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD CARLOS III DE MADRID Spain EU contribution € 127 797,44 Address CALLE MADRID 126 28903 Getafe (Madrid) See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Administrative Contact Regina Garcia Beato (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data