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Hybrid Fluorescence Molecular Tomography and X-ray Computed Tomography system and method

Objectif

This proposal offers to combine X-ray CT (XCT) and Fluorescence Molecular Tomography (FMT) into a hybrid, quantitative system and method. The project builds on state-of the-art knowledge that only recently became available in different European states as represented by the partners herein. In return it delivers the first such hybrid system worldwide. The system will operate by 1) co-registering XCT images with highly performing FMT images for merging anatomical, functional and molecular contrast and by 2) combining XCT information into the FMT inversion to provide a system with superior imaging performance. XCT-based correction, as explained in this proposal, can improve FMT performance in a more radical way than corresponding “correction methods” used for improving PET or SPECT images. In this way FMT-XCT can reach the imaging accuracy of radio-nuclei-based tomography hybrid systems. By using fluorescence, FMT-XCT can then enable high flexibility in targeting physiology and molecular function, especially in multi-spectral mode, and high dissemination potential because virtually any biomedical laboratory has access to fluorescence reporting, compared to radio-nuclei based research that requires access to radiochemistry and cyclotron facilities. FMT-XCT aims in advancing small animal imaging and drug discovery with a view towards the clinical application on non-invasive breast cancer imaging. For this reason, focus herein is given to imaging breast cancer and response to therapy. Overall the technology is ideally suited for commercial translation and has the potential to become the method of choice for in-vivo imaging in most biomedical laboratories and in select clinical applications. While it appreciates the value of nuclear imaging methods, this proposal will hopefully raise the funding necessary to establish on European ground a new potent paradigm of in-vivo imaging with high dissemination and application potential and large social and health-care impact .

Appel à propositions

FP7-HEALTH-2007-A
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Régime de financement

CP-FP - Small or medium-scale focused research project

Coordinateur

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Adresse
Ingolstadter Landstrasse 1
85764 Neuherberg
Allemagne
Type d’activité
Research Organisations
Contribution de l’UE
€ 1 294 102
Contact administratif
Juergen Ertel (Dr.)

Participants (7)

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Contribution de l’UE
€ 1 212 389
Adresse
Rue Leblanc 25
75015 Paris 15
Type d’activité
Research Organisations
Contact administratif
Olivier Leroy (Mr.)
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
Contribution de l’UE
€ 488 550
Adresse
N Plastira Str 100
70013 Irakleio
Type d’activité
Research Organisations
Contact administratif
Jorge Ripoll (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Contribution de l’UE
€ 409 600
Adresse
Gower Street
WC1E 6BT London
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Kent Lee (Mr.)
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON

Participation terminée

Espagne
Contribution de l’UE
€ 350 602,56
Adresse
Calle Doctor Esquerdo 46
28007 Madrid
Type d’activité
Other
Contact administratif
Jesús Maria Calavia Balduz (Mr.)
University of Zurich
Suisse
Contribution de l’UE
€ 365 600
Adresse
Ramistrasse 71
8006 Zurich
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Markus Rudin (Prof.)
CT Imaging GmbH
Allemagne
Contribution de l’UE
€ 263 500
Adresse
Henkestrasse, 91
91052 Erlangen
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Mandy Landmann (Ms.)
UNIVERSIDAD CARLOS III DE MADRID
Espagne
Contribution de l’UE
€ 127 797,44
Adresse
Calle Madrid 126
28903 Getafe (Madrid)
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Regina Garcia Beato (Ms.)