Objectif This proposal offers to combine X-ray CT (XCT) and Fluorescence Molecular Tomography (FMT) into a hybrid, quantitative system and method. The project builds on state-of the-art knowledge that only recently became available in different European states as represented by the partners herein. In return it delivers the first such hybrid system worldwide. The system will operate by 1) co-registering XCT images with highly performing FMT images for merging anatomical, functional and molecular contrast and by 2) combining XCT information into the FMT inversion to provide a system with superior imaging performance. XCT-based correction, as explained in this proposal, can improve FMT performance in a more radical way than corresponding “correction methods” used for improving PET or SPECT images. In this way FMT-XCT can reach the imaging accuracy of radio-nuclei-based tomography hybrid systems. By using fluorescence, FMT-XCT can then enable high flexibility in targeting physiology and molecular function, especially in multi-spectral mode, and high dissemination potential because virtually any biomedical laboratory has access to fluorescence reporting, compared to radio-nuclei based research that requires access to radiochemistry and cyclotron facilities. FMT-XCT aims in advancing small animal imaging and drug discovery with a view towards the clinical application on non-invasive breast cancer imaging. For this reason, focus herein is given to imaging breast cancer and response to therapy. Overall the technology is ideally suited for commercial translation and has the potential to become the method of choice for in-vivo imaging in most biomedical laboratories and in select clinical applications. While it appreciates the value of nuclear imaging methods, this proposal will hopefully raise the funding necessary to establish on European ground a new potent paradigm of in-vivo imaging with high dissemination and application potential and large social and health-care impact . Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesphysical sciencestheoretical physicsparticle physicsparticle acceleratornatural scienceschemical sciencesnuclear chemistryradiochemistrymedical and health sciencesclinical medicineoncologybreast cancermedical and health sciencesbasic medicinephysiology Mots‑clés 360-degree Anatomical Functional and Molecular imaging Free-space Free-space 360-degree Fluorescence Tomography Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH-2007-1.2-1 - Development of a hybrid imaging system HEALTH-2007-1.2-2 - Novel optical methodologies for detection, diagnosis and monitoring of disease or disease-related processes Appel à propositions FP7-HEALTH-2007-A Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Contribution de l’UE € 1 294 102,00 Adresse INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg Allemagne Voir sur la carte Région Bayern Oberbayern München, Landkreis Type d’activité Research Organisations Contact administratif Juergen Ertel (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France Contribution de l’UE € 1 212 389,00 Adresse RUE LEBLANC 25 75015 PARIS 15 Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Contact administratif Olivier Leroy (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée IDRYMA TECHNOLOGIAS KAI EREVNAS Grèce Contribution de l’UE € 488 550,00 Adresse N PLASTIRA STR 100 70013 Irakleio Voir sur la carte Région Νησιά Αιγαίου Κρήτη Ηράκλειο Type d’activité Research Organisations Contact administratif Jorge Ripoll (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITY COLLEGE LONDON Contribution de l’UE € 409 600,00 Adresse GOWER STREET WC1E 6BT LONDON Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Kent Lee (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON Participation terminée Espagne Contribution de l’UE € 350 602,56 Adresse CALLE DOCTOR ESQUERDO 46 28007 Madrid Voir sur la carte Région Comunidad de Madrid Comunidad de Madrid Madrid Type d’activité Other Contact administratif Jesús Maria Calavia Balduz (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée University of Zurich Suisse Contribution de l’UE € 365 600,00 Adresse RAMISTRASSE 71 8006 ZURICH Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Markus Rudin (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CT Imaging GmbH Allemagne Contribution de l’UE € 263 500,00 Adresse Henkestrasse, 91 91052 ERLANGEN Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Mandy Landmann (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSIDAD CARLOS III DE MADRID Espagne Contribution de l’UE € 127 797,44 Adresse CALLE MADRID 126 28903 Getafe (Madrid) Voir sur la carte Région Comunidad de Madrid Comunidad de Madrid Madrid Type d’activité Higher or Secondary Education Establishments Contact administratif Regina Garcia Beato (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée