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DIAbetes type 1 PRediction, Early Pathogenesis and Prevention

Objectif

The earliest currently identifiable process in the pathogenesis of type 1 diabetes (T1D) is the development of autoimmunity to islet beta cells in the form of autoantibodies. Hindering attempts to prevent autoimmune T1D, the aetiology and pathogenesis of the islet auto-immunization, including whether it is preceded by metabolic abnormalities and cell-mediated autoimmunity, is still poorly understood. To overcome this, DIAPREPP will focus on the early auto-immunization against islet antigens, in particular to disclose events preceding current autoantibody markers. The concept is that events prior to auto-immunization govern the likelihood and ‘signature’ of immunization, which in turn determines progression to disease. The overall objective is to determine mechanisms of islet autoantigen immunization. In a truly collaborative manner, and through five S/T workpackages plus three dedicated to dissemination, training, and management, DIAPREPP will 1. provide a unique set of clinical material that includes a case-control cohort representative of the world’s largest studies of pre-T1D, with follow-up and samples from birth, and pancreatic islets and lymph nodes from patients; 2. investigate the effects of environmental exposure to infections on islet cells and immune cells; 3. perform extensive metabolomic analysis of pre-autoimmune samples and in relevant animal models to test mechanistic hypotheses of auto-immunization; 4. carry out detailed analyses of early autoimmune responses with a special focus on autoreactive CD8+ T cells; and 5. apply findings to ongoing prevention studies. The expected impact of DIAPREPP is new fundamental knowledge regarding how 1. immunization against islet autoantigens can occur; 2. signs of self-immunization can be exploited for prediction and monitoring of disease; and 3. the immunization or its progression to islet beta cell destruction and T1D development can be prevented.

Appel à propositions

FP7-HEALTH-2007-A
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Coordinateur

TECHNISCHE UNIVERSITAET DRESDEN
Adresse
Helmholtzstrasse 10
01069 Dresden
Allemagne

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Sven Kreigenfeld (Mr.)
Contribution de l’UE
€ 909 751

Participants (11)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Contribution de l’UE
€ 600 956
Adresse
Rue De Tolbiac 101
75654 Paris

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Type d’activité
Research Organisations
Contact administratif
Annick Bertault (Ms.)
MAX IV Laboratory, Lund University
Suède
Contribution de l’UE
€ 501 993
Adresse
Paradisgatan 5c
22100 Lund

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Andreas Andersson (Dr.)
FORSCHERGRUPPE DIABETES E. V. - INSTITUT FUER DIABETESFORSCHUNG
Allemagne
Contribution de l’UE
€ 523 600
Adresse
Ingolstadter Landstrasse 1
85764 Oberschleissheim Neuherberg

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Type d’activité
Research Organisations
Contact administratif
Anette-G. Ziegler (Prof.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Finlande
Contribution de l’UE
€ 808 444
Adresse
Tekniikantie 4 A
02044 VTT Espoo

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Type d’activité
Research Organisations
Contact administratif
Katri Kokkila (Ms.)
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italie
Contribution de l’UE
€ 460 400
Adresse
Via Olgettina 60
20132 Milano

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Type d’activité
Research Organisations
Contact administratif
Maria Rosa Pedrazzi (Dr.)
UPPSALA UNIVERSITET
Suède
Contribution de l’UE
€ 481 212
Adresse
Von Kraemers Alle 4
751 05 Uppsala

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Olle Korsgren (Prof.)
UNIVERSITAT DE BARCELONA
Espagne
Contribution de l’UE
€ 219 200
Adresse
Gran Via De Les Corts Catalanes 585
08007 Barcelona

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Marta Cascante (Prof.)
ZORA BIOSCIENCES OY
Finlande
Contribution de l’UE
€ 205 344
Adresse
Tietotie 2 C
02150 Espoo

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Reini Hurme (Dr.)
RSR LIMITED
United Kingdom
Contribution de l’UE
€ 175 500
Adresse
Avenue Park, Pantwyn
CF23 8HE Cardiff

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Bernard Rees Smith (Dr.)
VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finlande
Contribution de l’UE
€ 523 400
Adresse
Kiinamyllynkatu 4-8
20520 Turku

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Type d’activité
Research Organisations
Contact administratif
Risto Laalo (Mr.)
TERVEYDEN JA HYVINVOINNIN LAITOS
Finlande
Contribution de l’UE
€ 589 400
Adresse
Mannerheimintie 166
00271 Helsinki

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Type d’activité
Research Organisations
Contact administratif
Jaakko Penttinen (Mr.)