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Understanding computational roles of new neurons generated in the adult hippocampus

Objective

New neurons are continuously generated in certain regions of adult mammalian brain. One of those regions is the dentate gyrus, a subregion of hippocampus, which is essential for memory formation. Although these new neurons in the adult dentate gyrus are thought to have an important role in learning and memory, it is largely unclear how new neurons are involved in information processing and storage underlying memory. Because new neurons constitute a minor portion of intermingled local neuronal population, simple application of conventional techniques such as multi-unit extracellular recording and pharmacological lesion are not suitable for the functional analysis of new neurons. In this proposed research program, I will combine multi-unit recording and behavioral analysis with virus mediated, cell-type-specific genetic manipulation of neuronal activity, to investigate computational roles of new neurons in learning and memory. Specifically, I will determine: 1) specific memory processes that require new neurons, 2) dynamic patterns of activity that new neurons express during memory-related behavior, 3) influence of new neurons on their downstream structure. Further, based on the information obtained by these three lines of studies, we will establish causal relationship between specific memory-related behavior and specific pattern of activity in new neurons. Solving these issues will cooperatively provide important insight into the understanding of computational roles performed by adult neurogenesis. The information on the function of new neurons in normal brain could contribute to future development of efficient therapeutic strategy for a variety of brain disorders.

Field of science

  • /natural sciences/computer and information sciences/data science/data processing

Call for proposal

ERC-2007-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Address
Hogskoleringen 1
7491 Trondheim
Norway
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 673 743
Principal investigator
Ayumu Tashiro (Ph.D.)
Administrative Contact
Stig Slordahl (Prof.)

Beneficiaries (2)

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 1 673 743
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments
Principal investigator
Ayumu Tashiro (Ph.D.)
Administrative Contact
Stig Slordahl (Prof.)
NANYANG TECHNOLOGICAL UNIVERSITY
Singapore
EU contribution
€ 318 000
Address
Nanyang Avenue 50
639798 Singapore
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mei Fong Loong (Ms.)