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The mechanisms of cardiovascular risks after low radiation doses

Objective

Recent epidemiologic evidence suggests that moderate and low radiation doses to the heart may result in a moderate, but significant increase in cardiovascular mortality. So far, the pathogenesis of radiation induced heart disease has not been studied in detail. Pathohistologic studies suggest that microvascular damage plays a crucial role in the development of radiation induced cardiovascular disease. In addition, radiation may increase atherosclerotic lesions in the coronary arteries. The aim of this collaborative research project is to elucidate the pathogenesis of early and late alteration in the microcirculation of the heart and of atherosclerotic lesions in arteries after exposure to low radiation doses in comparison to high radiation doses. A major goal will be the investigation of early molecular, proinflammatory and prothrombotic changes as well as perfusion alteration, cardiac cell integrity and immunologic influences. To achieve this goal, in vivo as well as ex vivo and in vitro studies will be performed. A central component of the project will be the local irradiation of the heart with subsequent isolation of cardiomyocytes and cardiac endothelial cells to provide all participating groups with the same biological material for further study. In addition, structural, morphological and molecular studies will be complemented by functional assays and imaging methods.

Call for proposal

FP7-Fission-2007
See other projects for this call

Coordinator

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Address
Ismaninger Strasse 22
81675 Muenchen
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 437 794
Administrative Contact
Claudia Speiser (Ms.)

Participants (12)

TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 439 410
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wolfgang Dörr (Prof.)
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 239 843
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
Administrative Contact
Henri Van Luenen (Dr.)
INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIRE
France
EU contribution
€ 234 919
Address
Av De La Division Leclerc 31
92260 Fontenay Aux Roses
Activity type
Research Organisations
Administrative Contact
Marie-Catherine Vozenin-Brotons (Dr.)
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 162 941
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colleen Spence (Ms.)
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 196 484
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gill Wells (Ms.)
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
Poland
EU contribution
€ 102 000
Address
Ul. W K Roentgena 5
02781 Warszawa
Activity type
Research Organisations
Administrative Contact
Piotr Widlak (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 196 912
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 196 219
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrich Roessler (Mr.)
SATEILYTURVAKESKUS
Finland
EU contribution
€ 200 150
Address
Laippatie 4
00880 Helsinki
Activity type
Research Organisations
Administrative Contact
Jaana Mannonen (Ms.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 291 636
Address
Minderbroedersberg 4
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rob Van Der Zander (Mr.)
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG
Germany
EU contribution
€ 112 400
Address
Oskar Von Miller Ring 29
80333 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Fuchs (Ms.)
UNIVERSITAET ROSTOCK
Germany
EU contribution
€ 49 189
Address
Universitatsplatz 1
18055 Rostock
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margitta Paucker (Ms.)