Objective According to the World Health Organisation (WHO), cardiovascular diseases cause half the deaths in the EU. It is also the main cause of years of life lost (over 30 per cent) in early death thus causing huge pressure on the labour force and family earnings. The problem is becoming more acute in Central and Eastern European countries. Due to the ageing population in the EU, osteoporosis related bone fractures have almost doubled in the last decade. It is estimated that 40 percent of women over 50 years in age will suffer from fractures due to low density bone. The European Commission considers the application of nanotechnology an important research strategy to address these problems. For this, design and control of biomaterial at the nanometer scale is set as a strategic research priority. Europe is, however, seriously under-represented in the global market for nanotherapeutics, where the United States dominates with three-quarter of the market share. While the drive for nanoscale understanding of biological interaction can be high, the application of this knowledge in marketable devices should also be prioritised. Here, we propose electrical modification of biomaterials surface to manipulate surface charge that will mediate bio/non bio interactions in vivo. We propose novel nanoscale techniques to probe this surface charge at the nanometer scale so that we have a quantitative insight to biological interaction at the biomedical device surfaces. Such an approach will help us to scale up electrical modification in cardiovascular stents, urological stents, orthopedic implants and photosterilisation devices. The research proposed here will not only provide nanoscale understanding of biological interactions on biomaterials surface but also result in novel applications and devices, which will penetrate into the market in short to medium term. Fields of science engineering and technologynanotechnologymedical and health sciencesclinical medicinecardiologycardiovascular diseasesnatural sciencesbiological sciencesbiological behavioural sciencesethologybiological interactionsengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesmedical biotechnologyimplants Keywords bio-nonbio interaction biomaterials biomedical device bone implant cells encrustation nanoarray nanomanipulation nanomaterials stents sterilisation surface charge surface modification Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-1.1-1 - Nano-scale mechanisms of bio/non-bio interactions NMP-2007-2.1-2 - Nanostructured coatings and thin films Call for proposal FP7-NMP-2007-SMALL-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITY OF LIMERICK Address National technological park, plassey - Limerick Ireland See on map Region Ireland Northern and Western Border Activity type Higher or Secondary Education Establishments Administrative Contact Syed A. M. Tofail (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 994 400,00 Participants (12) Sort alphabetically Sort by EU Contribution Expand all Collapse all POLITECHNIKA WROCLAWSKA Poland EU contribution € 355 600,00 Address Wybrzeze wyspianskiego 27 50-370 Wroclaw See on map Region Makroregion południowo-zachodni Dolnośląskie Miasto Wrocław Activity type Higher or Secondary Education Establishments Administrative Contact Halina Podbielska (Prof.) Links Contact the organisation Opens in new window Website Opens in new window TECHNISCHE UNIVERSITAET DRESDEN Germany EU contribution € 466 560,00 Address Helmholtzstrasse 10 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Sven Kreigenfeld (Mr.) Links Contact the organisation Opens in new window Website Opens in new window TEKNOLOGISK INSTITUT Denmark EU contribution € 470 719,00 Address Gregersensvej 1 2630 Taastrup See on map Region Danmark Hovedstaden Københavns omegn Activity type Research Organisations Administrative Contact Naseem Theilgaard Links Contact the organisation Opens in new window Website Opens in new window UNIVERZITA KOMENSKEHO V BRATISLAVE Slovakia EU contribution € 226 640,00 Address Safarikovo nam 6 814 99 Bratislava See on map Region Slovensko Bratislavský kraj Bratislavský kraj Activity type Higher or Secondary Education Establishments Administrative Contact Andrej Plecenik (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITATEA POLITEHNICA DIN BUCURESTI Romania EU contribution € 132 844,00 Address Splaiul independentei 313 sect 6 060042 Bucharest See on map Region Macroregiunea Trei Bucureşti-Ilfov Bucureşti Activity type Higher or Secondary Education Establishments Administrative Contact George Stanciu (Prof.) Links Contact the organisation Opens in new window Website Opens in new window BEN-GURION UNIVERSITY OF THE NEGEV Israel EU contribution € 178 240,00 Address . 84105 Beer sheva See on map Activity type Higher or Secondary Education Establishments Administrative Contact Sidney Lang (Prof.) Links Contact the organisation Opens in new window Website Opens in new window PETER BREHM Germany EU contribution € 154 080,00 Address Am muhlberg 30 91085 Weisendorf See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bernhard Kleffner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window COOK IRELAND LIMITED Ireland EU contribution € 112 280,00 Address O halloran road n/a Limerick See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Shay Lavelle (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU Poland EU contribution € 258 120,00 Address Ul pasteura 1 50 367 Wroclaw See on map Region Makroregion południowo-zachodni Dolnośląskie Miasto Wrocław Activity type Higher or Secondary Education Establishments Administrative Contact Walentyna Mazurek (Prof.) Links Contact the organisation Opens in new window Website Opens in new window BALTON SPOLKA ZOO Poland EU contribution € 99 960,00 Address Nowy swiat 7 m 14 00 496 Warszawa See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Leszek Hurkala (Mr.) Links Contact the organisation Opens in new window Website Opens in new window BeoCare Limited Participation ended Ireland EU contribution € 0,00 Address Park road N/A Killarney See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eoin Collins (Mr.) Links Contact the organisation Opens in new window Website Opens in new window NATIONAL UNIVERSITY OF IRELAND GALWAY Ireland EU contribution € 91 200,00 Address University road H91 Galway See on map Region Ireland Northern and Western West Activity type Higher or Secondary Education Establishments Administrative Contact Gerard Wall (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
