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Electrically modified biomaterials surface

Objective

According to the World Health Organisation (WHO), cardiovascular diseases cause half the deaths in the EU. It is also the main cause of years of life lost (over 30 per cent) in early death thus causing huge pressure on the labour force and family earnings. The problem is becoming more acute in Central and Eastern European countries. Due to the ageing population in the EU, osteoporosis related bone fractures have almost doubled in the last decade. It is estimated that 40 percent of women over 50 years in age will suffer from fractures due to low density bone. The European Commission considers the application of nanotechnology an important research strategy to address these problems. For this, design and control of biomaterial at the nanometer scale is set as a strategic research priority. Europe is, however, seriously under-represented in the global market for nanotherapeutics, where the United States dominates with three-quarter of the market share. While the drive for nanoscale understanding of biological interaction can be high, the application of this knowledge in marketable devices should also be prioritised. Here, we propose electrical modification of biomaterials surface to manipulate surface charge that will mediate bio/non bio interactions in vivo. We propose novel nanoscale techniques to probe this surface charge at the nanometer scale so that we have a quantitative insight to biological interaction at the biomedical device surfaces. Such an approach will help us to scale up electrical modification in cardiovascular stents, urological stents, orthopedic implants and photosterilisation devices. The research proposed here will not only provide nanoscale understanding of biological interactions on biomaterials surface but also result in novel applications and devices, which will penetrate into the market in short to medium term.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/biological sciences/biological behavioural sciences/ethology/biological interaction
  • /engineering and technology/nanotechnology
  • /engineering and technology/industrial biotechnology/biomaterials
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

FP7-NMP-2007-SMALL-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITY OF LIMERICK
Address
National Technological Park, Plassey
- Limerick
Ireland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 994 400
Administrative Contact
Syed A. M. Tofail (Dr.)

Participants (12)

POLITECHNIKA WROCLAWSKA
Poland
EU contribution
€ 355 600
Address
Wybrzeze Wyspianskiego 27
50-370 Wroclaw
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Halina Podbielska (Prof.)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 466 560
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sven Kreigenfeld (Mr.)
TEKNOLOGISK INSTITUT
Denmark
EU contribution
€ 470 719
Address
Gregersensvej 1
2630 Taastrup
Activity type
Research Organisations
Administrative Contact
Naseem Theilgaard
UNIVERZITA KOMENSKEHO V BRATISLAVE
Slovakia
EU contribution
€ 226 640
Address
Safarikovo Nam 6
814 99 Bratislava
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrej Plecenik (Prof.)
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Romania
EU contribution
€ 132 844
Address
Splaiul Independentei 313 Sect 6
060042 Bucharest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
George Stanciu (Prof.)
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 178 240
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sidney Lang (Prof.)
PETER BREHM
Germany
EU contribution
€ 154 080
Address
Am Muhlberg 30
91085 Weisendorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bernhard Kleffner (Dr.)
COOK IRELAND LIMITED
Ireland
EU contribution
€ 112 280
Address
O Halloran Road
n/a Limerick
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Shay Lavelle (Mr.)
UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU
Poland
EU contribution
€ 258 120
Address
Ul Pasteura 1
50 367 Wroclaw
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Walentyna Mazurek (Prof.)
BALTON SPOLKA ZOO
Poland
EU contribution
€ 99 960
Address
Nowy Swiat 7 M 14
00 496 Warszawa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Leszek Hurkala (Mr.)
BeoCare Limited

Participation ended

Ireland
Address
Park Road
N/A Killarney
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eoin Collins (Mr.)
NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 91 200
Address
University Road
H91 Galway
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerard Wall (Dr.)