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Developmental effects of environment on reproductive health

Objective

The multidisciplinary research teams in this consortium have played lead roles in establishing that fetal and childhood periods are vulnerable to environmental disruption leading to common reproductive disorders. This proposal will investigate: (1) connections between normal/abnormal perinatal reproductive development and maturation of reproductive function at puberty and in adulthood; (2) systemic gene-environment interactions underlying reproductive disorders taking account of genetic susceptibility, multiple exposures (e.g. mixtures of environmental chemicals) and their timing (perinatal, peripubertal, adult); (3) connection between perinatal reproductive development and later obesity/metabolic disorders. To achieve this we will utilize large cohorts generated in previous EU projects and collect new data from these on reproductive maturation and adult function. Existing genomic and proteomics data, exposure data for >100 potentially toxic environmental chemicals, lifestyle, dietary and medical history information will be analysed using integrative systems biology approaches to pinpoint critical (interacting) factors influencing development. Established animal models will be used to test putative mechanisms by analysing the roles of neuroendocrine regulation, intrauterine growth, time windows of reproductive development, metabolic balance and xenobiotic metabolism. Toxicogenomics, proteomics and metabolomics results from these studies will identify pathways for study in the human cohorts. The overall aim is to create new cause-effect frameworks and knowledge networks to refine research in this critical area and to identify novel biomarkers of exposure and disease. The proposed studies will facilitate prediction and prevention of reproductive disorders and provide large new datasets and exposure-outcome information to improve environmental risk assessment and risk management.

Call for proposal

FP7-ENV-2007-1
See other projects for this call

Coordinator

TURUN YLIOPISTO
Address
Yliopistonmaki
20014 Turku
Finland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 495 424
Administrative Contact
Eliisa Särkilahti (Dr.)

Participants (8)

RIGSHOSPITALET
Denmark
EU contribution
€ 961 703
Address
Blegdamsvej 9
2100 Koepenhagen
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Joergen Joergensen (Mr.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 448 272
Address
North Star Avenue Polaris House
SN2 1FL Swindon
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Patricia Young (Ms.)
UNIVERSIDAD DE CORDOBA
Spain
EU contribution
€ 349 711
Address
Avenida De Medina Azahara 5
14005 Cordoba
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enrique Aguilar Benitez De Lugo (Prof.)
UNIVERSITE DE RENNES I
France
EU contribution
€ 348 894
Address
Rue Du Thabor 2
35065 Rennes Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yolaine Bompays (Ms.)
INSTITUTE OF EXPERIMENTAL MORPHOLOGY AND ANTHROPOLOGY WITH MUSEUM- BAS
Bulgaria
EU contribution
€ 77 714
Address
Akad G Bonchev Street, Block 25
1113 Sofia
Activity type
Research Organisations
Administrative Contact
Yordan Yordanov (Prof.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 310 771
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karen Bue Bitsch (Ms.)
UNIVERSITY OF ROCHESTER
United States
EU contribution
€ 99 999
Address
Elmwood Avenue, Box Ehsc 601
14642 Rochester Ny
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marlene Boutet (Ms.)
ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE
France
EU contribution
€ 406 540
Address
Site De La Chantrerie, Route De Gachet
44307 Nantes
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Raoul (Ms.)