Objectif The multidisciplinary research teams in this consortium have played lead roles in establishing that fetal and childhood periods are vulnerable to environmental disruption leading to common reproductive disorders. This proposal will investigate: (1) connections between normal/abnormal perinatal reproductive development and maturation of reproductive function at puberty and in adulthood; (2) systemic gene-environment interactions underlying reproductive disorders taking account of genetic susceptibility, multiple exposures (e.g. mixtures of environmental chemicals) and their timing (perinatal, peripubertal, adult); (3) connection between perinatal reproductive development and later obesity/metabolic disorders. To achieve this we will utilize large cohorts generated in previous EU projects and collect new data from these on reproductive maturation and adult function. Existing genomic and proteomics data, exposure data for >100 potentially toxic environmental chemicals, lifestyle, dietary and medical history information will be analysed using integrative systems biology approaches to pinpoint critical (interacting) factors influencing development. Established animal models will be used to test putative mechanisms by analysing the roles of neuroendocrine regulation, intrauterine growth, time windows of reproductive development, metabolic balance and xenobiotic metabolism. Toxicogenomics, proteomics and metabolomics results from these studies will identify pathways for study in the human cohorts. The overall aim is to create new cause-effect frameworks and knowledge networks to refine research in this critical area and to identify novel biomarkers of exposure and disease. The proposed studies will facilitate prediction and prevention of reproductive disorders and provide large new datasets and exposure-outcome information to improve environmental risk assessment and risk management. Champ scientifique sciences naturellessciences biologiquesbiochimiebiomoléculeprotéinesprotéomiquesciences médicales et de la santésciences de la santésciences biomédicales socialessanté sexuelle Mots‑clés development endocrine disruption environment gene-environment interaction metabolomics proteomics reproductive health toxicogenomics Programme(s) FP7-ENVIRONMENT - Specific Programme "Cooperation": Environment (including Climate Change) Thème(s) ENV.2007.1.2.1.2. - Environmental factors and their impact on reproduction and development Appel à propositions FP7-ENV-2007-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur TURUN YLIOPISTO Adresse Yliopistonmaki 20014 Turku Finlande Voir sur la carte Région Manner-Suomi Etelä-Suomi Varsinais-Suomi Type d’activité Higher or Secondary Education Establishments Contact administratif Eliisa Särkilahti (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Contribution de l’UE Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire RIGSHOSPITALET Danemark Contribution de l’UE € 961 703,00 Adresse Blegdamsvej 9 2100 Koepenhagen Voir sur la carte Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Joergen Joergensen (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée MEDICAL RESEARCH COUNCIL Royaume-Uni Contribution de l’UE € 448 272,00 Adresse 20 park crescent W1B 1AL London Voir sur la carte Type d’activité Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contact administratif Patricia Young (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée UNIVERSIDAD DE CORDOBA Espagne Contribution de l’UE € 349 711,00 Adresse Avenida de medina azahara 5 14005 Cordoba Voir sur la carte Région Sur Andalucía Córdoba Type d’activité Higher or Secondary Education Establishments Contact administratif Enrique Aguilar Benitez De Lugo (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée UNIVERSITE DE RENNES I France Contribution de l’UE € 348 894,00 Adresse Rue du thabor 2 35065 Rennes cedex Voir sur la carte Région Bretagne Bretagne Ille-et-Vilaine Type d’activité Higher or Secondary Education Establishments Contact administratif Yolaine Bompays (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée INSTITUTE OF EXPERIMENTAL MORPHOLOGY AND ANTHROPOLOGY WITH MUSEUM- BAS Bulgarie Contribution de l’UE € 77 714,00 Adresse Akad g bonchev street, block 25 1113 Sofia Voir sur la carte Type d’activité Research Organisations Contact administratif Yordan Yordanov (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée DANMARKS TEKNISKE UNIVERSITET Danemark Contribution de l’UE € 310 771,00 Adresse Anker engelunds vej 101 2800 Kongens lyngby Voir sur la carte Région Danmark Hovedstaden Københavns omegn Type d’activité Higher or Secondary Education Establishments Contact administratif Karen Bue Bitsch (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée UNIVERSITY OF ROCHESTER États-Unis Contribution de l’UE € 99 999,00 Adresse Elmwood avenue, box ehsc 601 14642 Rochester ny Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Marlene Boutet (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée ECOLE NATIONALE VETERINAIRE, AGROALIMENTAIRE ET DE L'ALIMENTATION NANTES ATLANTIQUE France Contribution de l’UE € 406 540,00 Adresse Site de la chantrerie, route de gachet 44307 Nantes Voir sur la carte Région Pays de la Loire Pays de la Loire Loire-Atlantique Type d’activité Higher or Secondary Education Establishments Contact administratif Celine Raoul (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Autres sources de financement Aucune donnée
