Objective
Understanding parasite virulence is a challenge for evolutionary biology. Intuitively, parasites that rely on their hosts for their fitness should be benign, yet many parasites cause harm (virulence). Two main theories exist to explain parasite virulence. First, it is believed that virulence is an unavoidable consequence of a parasite maximising its fitness: in order to obtain transmission to the next host, it needs to exploit its current host, at the same time causing damage. Second, within-host competition between parasite strains infecting the same host could select for higher levels of virulence, because selfish competition will favour those strains that exploit their hosts more rapidly than competitors. Although many theoreticians have addressed these theories, there is hardly any experimental evidence to confirm them, severely limiting a proper understanding of the ecological processes (and human interventions) that shape parasite virulence evolution. I propose to study these two theories experimentally , using Ophryocystis parasites in monarch butterflies (Emory University) and malaria parasites in mosquitoes (University of Edinburgh). Carrying out laboratory and field studies on monarch parasites at Emory University, I will obtain expertise in studying naturally occurring insect-parasite systems, which I will transfer to studying malaria parasites in mosquitoes upon my return to Edinburgh. Carrying out laboratory studies on mosquitoes first, I have a long-term vision of taking these studies further to study malaria virulence evolution in the field; with human interventions already well under way, experimental studies on parasite virulence are long overdue. Combining the knowledge of two different systems and the infrastructure at two different institutes will not only enhance our understanding of parasite virulence, but also greatly contribute to my scientific maturation and my career in evolutionary biology of disease, which I wish to realise in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases malaria
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences zoology invertebrate zoology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.