Objective The demographic changes in Europe towards an aging society will coincide with increasing morbidity of the population. European citizens need improved access to state-of-the-art medical care especially in oncology and cardiology, while keeping expenditures on healthcare affordable. New therapeutic options such as externally triggered local drug release at the diseased area hold promise to solve urgent medical needs: improved treatment with reduced side effects, fewer burdens to the patient and faster recovery after intervention. Nanomedicine, the application of nanomaterials and nanotechnology to healthcare, will enable breakthroughs in clinical practice. SONODRUGS addresses clinical needs by developing novel drug delivery technologies for localised treatment of cardiovascular disease and cancer. SONODRUGS develops drug delivery concepts where drug release can be triggered by focused ultrasound induced pressure or temperature stimuli within the diseased tissue. New drug loaded nanocarriers will be designed for tailored drug delivery systems that respond to either of the two stimuli. Medical imaging, i.e. magnetic resonance imaging and ultrasound imaging, will be used to guide, follow and quantify the drug delivery process. Therapy efficacy using different drug delivery systems will be assessed in vitro and subsequently in preclinical studies. Starting form research on a broad range of materials and drugs, two nanocarriers will be finally selected, optimized and produced on a pilot scale in combination with image-guided delivery tools and methods. SONODRUGS binds expertise in materials research (Philips, TUE, GhentRGN, HBBG); material production (Nanobiotix, Lipoid); clinical knowledge in oncology (UTours, HBBG) and cardiology (UKB); in vitro and preclinical validation (UTours, ErasmusMC, UKB); research on imaging techniques (UCY, Philips, IMF); pharmacokinetics, toxicology and biodistribution (ULSOP, IPT). Fields of science medical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesclinical medicineoncologyengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingnatural sciencesphysical sciencesacousticsultrasound Keywords Local delivery nanomedicine nanocarriers oncology cardiology drug Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-4.0-4 - Substantial innovation in the European medical industry: development of nanotechnology-based systems for in-vivo diagnosis and therapy (in coordination with topic HEALTH-2007-2.4.1-7 and HEALTH-2007-1.2-3 in Theme 1 "Health") Call for proposal FP7-NMP-2007-LARGE-1 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator PHILIPS ELECTRONICS NEDERLAND BV EU contribution € 2 669 228,40 Address HIGH TECH CAMPUS 52 5656 AG Eindhoven Netherlands See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Keur (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all PHILIPS TECHNOLOGIE GMBH Germany EU contribution € 339 503,00 Address LUEBECKERTORDAMM 5 20099 HAMBURG See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Keur (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LIPOID GMBH Germany EU contribution € 115 200,00 Address FRIGENSTRASSE 4 67065 LUDWIGSHAFEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Katharina Sauter (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NANOBIOTIX SA France EU contribution € 738 000,00 Address RUE DE WATTIGNIES, BATIMENT B 60 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kader Boussaha (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF CYPRUS Cyprus EU contribution € 404 910,00 Address AVENUE PANEPISTIMIOU 2109 AGLANTZI 1678 Nicosia See on map Region Κύπρος Κύπρος Κύπρος Activity type Higher or Secondary Education Establishments Administrative Contact Antreas Christofides (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT GENT Belgium EU contribution € 839 952,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Administrative Contact Nathalie Vandepitte (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELSINGIN YLIOPISTO Participation ended Finland EU contribution € 383 608,00 Address YLIOPISTONKATU 3 00014 Helsingin Yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Administrative Contact Katariina Vainio-Mattila (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution No data Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kostas Kostarelos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITEIT EINDHOVEN Netherlands EU contribution € 887 840,00 Address GROENE LOPER 3 5612 AE Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Higher or Secondary Education Establishments Administrative Contact Rob Debeij (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE DE TOURS France EU contribution € 472 353,60 Address RUE DU PLAT D ETAIN 60 37020 Tours See on map Region Centre — Val de Loire Centre — Val de Loire Indre-et-Loire Activity type Higher or Secondary Education Establishments Administrative Contact Marie Bechtet (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE VICTOR SEGALEN BORDEAUX II Participation ended France EU contribution € 426 778,00 Address RUE LEO SAIGNAT 146 33076 BORDEAUX CEDEX See on map Activity type Higher or Secondary Education Establishments Administrative Contact Chrit Moonen (Dr.) Links Contact the organisation Opens in new window Total cost No data PHILIPS OY Finland EU contribution € 239 000,00 Address AYRITIE 4 01511 VANTAA See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Panu Kauppila (Mr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI UDINE Participation ended Italy EU contribution € 38 115,00 Address VIA PALLADIO 8 33100 Udine See on map Region Nord-Est Friuli-Venezia Giulia Udine Activity type Higher or Secondary Education Establishments Administrative Contact Mario Furnalut (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 681 092,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Nico De Jong (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Westfälische Wilhelms-Universität Münster Germany EU contribution € 790 911,00 Address SCHLOSSPLATZ 2 48149 MUENSTER See on map Region Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Karl-Heinz Runde (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AALTO KORKEAKOULUSAATIO SR Finland EU contribution € 307 416,00 Address OTAKAARI 1 02150 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Administrative Contact Paavo Kinnunen (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 476 066,00 Address HEIDELBERGLAAN 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Marieke Krispijn (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON Participation ended United Kingdom EU contribution € 973 927,00 Address Brunswick Square 29-39 WC1N 1AX LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kostas Kostarelos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data