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Single Molecule Workstation

Objective

This proposal aims at the development and application of an innovative single molecule workstation, enabling advances in the research happening throughout Europe and the rest of the world around the investigation of living cells. By combining three most advanced microscopic techniques into a single workstation, we aim at reaching a new quality level in the study of the molecular biology of living cells. The proposed single molecule workstation will be composed of three key elements: (i) inverted light microscope (ILM); (ii) atomic force microscope (AFM); and (iii) optical tweezers (OT). A true virtue of this initiative is that by combining several ultra-sensitive microscopy techniques into a single workstation completely new horizons for molecular biology related studies are opened. The aim of this combined ILM-AFM-OT setup is to look at the surface topography using high-resolution AFM, to study the distribution of cellular molecules using high sensitive fluorescence and contrast enhanced light microscopy (ILM), and to measure molecular interaction forces with ultra-sensitive optical tweezers. As a complementary method, photo-thermal nano-spectroscopy (PTNS) will be used to investigate spectroscopic properties of cellular material with a spatial resolution down to sub-100 nm which will enable chemical analysis of sub-cellular components. The combined setup will provide a qualitatively new level in microscopic studies, giving unprecedented versatility in the detection and monitoring of cellular events with highest spatial and temporal resolution. The proposed single workstation will be used for the study of the correlation between structure and function of living cells with applications in immunology and cancer research.

Call for proposal

FP7-NMP-2007-SME-1
See other projects for this call

Coordinator

TILL I.D. GMBH
Address
Bahnhofstrasse 89
82166 Grafelfing
Germany
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 413 600
Administrative Contact
Stefanie Graf (Dr.)

Participants (9)

ANASYS INSTRUMENTS LIMITED
United Kingdom
EU contribution
€ 191 500
Address
Lovelstaithe 7
NR1 1LW Norwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roshan Shetty
MULTIPLE IMAGE TOOLS GMBH

Participation ended

Germany
EU contribution
€ 141 600
Address
Schwaansche Strasse 1
18055 Rostock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Raik Madla (Mr.)
AGILENT TECHNOLOGIES OSTERREICH GMBH
Austria
EU contribution
€ 292 698
Address
Mooslackengasse 17
1190 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ferry Kienberger (Dr.)
THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS, POLISH ACADEMY OF SCIENCES
Poland
EU contribution
€ 139 500
Address
Radzikowskiego 152
31 342 Krakow
Activity type
Research Organisations
Administrative Contact
Magdalena Zawora (Ms.)
HOLOEYE PHOTONICS AG
Germany
EU contribution
€ 324 600
Address
Volmerstrasse 1
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mika Gornig (Mr.)
UNIVERSITAT LINZ
Austria
EU contribution
€ 366 700
Address
Altenberger Strasse 69
4040 Linz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hinterdorfer (Prof.)
TILL Photonics GmbH

Participation ended

Germany
EU contribution
€ 31 272
Address
Lochhamer Schlag 19
82166 Grafelfing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Seele (Dr.)
TILL PHOTONICS GMBH
Germany
EU contribution
€ 146 680
Address
Lochhamer Schlag 21
82166 Grafelfing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Seele (Dr.)
ARIVIS GMBH
Germany
EU contribution
€ 18 000
Address
Kropeliner Strasse 54
18055 Rostock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christian Götze (Mr.)