Objective This proposal aims at the development and application of an innovative single molecule workstation, enabling advances in the research happening throughout Europe and the rest of the world around the investigation of living cells. By combining three most advanced microscopic techniques into a single workstation, we aim at reaching a new quality level in the study of the molecular biology of living cells. The proposed single molecule workstation will be composed of three key elements: (i) inverted light microscope (ILM); (ii) atomic force microscope (AFM); and (iii) optical tweezers (OT). A true virtue of this initiative is that by combining several ultra-sensitive microscopy techniques into a single workstation completely new horizons for molecular biology related studies are opened. The aim of this combined ILM-AFM-OT setup is to look at the surface topography using high-resolution AFM, to study the distribution of cellular molecules using high sensitive fluorescence and contrast enhanced light microscopy (ILM), and to measure molecular interaction forces with ultra-sensitive optical tweezers. As a complementary method, photo-thermal nano-spectroscopy (PTNS) will be used to investigate spectroscopic properties of cellular material with a spatial resolution down to sub-100 nm which will enable chemical analysis of sub-cellular components. The combined setup will provide a qualitatively new level in microscopic studies, giving unprecedented versatility in the detection and monitoring of cellular events with highest spatial and temporal resolution. The proposed single workstation will be used for the study of the correlation between structure and function of living cells with applications in immunology and cancer research. Fields of science natural sciencesphysical sciencesopticsmicroscopymedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesmolecular biology Keywords AFM ILM Inverted Light Microscope Nanotechnology OT Optical Trap PTNS advanced microscopic techniques photo-thermal nano-spectroscopy single molecule workstation Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-1.2-2 - Analysis of the ethical, regulatory, social and economic environment of nanomedicine Call for proposal FP7-NMP-2007-SME-1 See other projects for this call Funding Scheme CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinator TILL I.D. GMBH EU contribution € 413 600,00 Address BAHNHOFSTRASSE 89 82166 GRAFELFING Germany See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stefanie Graf (Dr.) Links Contact the organisation Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all ANASYS INSTRUMENTS LIMITED United Kingdom EU contribution € 191 500,00 Address LOVELSTAITHE 7 NR1 1LW NORWICH See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Roshan Shetty Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MULTIPLE IMAGE TOOLS GMBH Participation ended Germany EU contribution € 141 600,00 Address SCHWAANSCHE STRASSE 1 18055 ROSTOCK See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Raik Madla (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGILENT TECHNOLOGIES OSTERREICH GMBH Austria EU contribution € 292 698,00 Address MOOSLACKENGASSE 17 1190 WIEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ferry Kienberger (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS, POLISH ACADEMY OF SCIENCES Poland EU contribution € 139 500,00 Address RADZIKOWSKIEGO 152 31 342 Krakow See on map Region Makroregion południowy Małopolskie Miasto Kraków Activity type Research Organisations Administrative Contact Magdalena Zawora (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HOLOEYE PHOTONICS AG Germany EU contribution € 324 600,00 Address VOLMERSTRASSE 1 12489 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mika Gornig (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT LINZ Austria EU contribution € 366 700,00 Address ALTENBERGER STRASSE 69 4040 Linz See on map Region Westösterreich Oberösterreich Linz-Wels Activity type Higher or Secondary Education Establishments Administrative Contact Peter Hinterdorfer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TILL Photonics GmbH Participation ended Germany EU contribution € 31 272,00 Address Lochhamer Schlag 19 82166 GRAFELFING See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Seele (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TILL PHOTONICS GMBH Germany EU contribution € 146 680,00 Address LOCHHAMER SCHLAG 21 82166 GRAFELFING See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Seele (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARIVIS GMBH Germany EU contribution € 18 000,00 Address KROPELINER STRASSE 54 18055 ROSTOCK See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christian Götze (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
