Skip to main content

Understanding interactions between cells and nanopatterned surfaces

Objective

The study of biological processes occurring at the nanoscale is becoming a new discipline at the border between Physics and Biology with major scientific challenges and new technological applications. In fact, interactions at the nanoscale between cells/neurons and surfaces with specific nanopatterns appear to control several major biological processes, such as cell proliferation and differentiation. The aim of the present NanoScale proposal is therefore to explore interactions between stem cells, neurons, neuronal networks and surfaces with specific geometrical nanopatterns and nanoprints of specific proteins and molecules. In order to do so, we have formed an interdisciplinary consortium consisting of five major European research centres (SISSA, TASC-INFM, DTU, NMI and ENS) with two SMEs (MCS, Promoscience) gathering biological knowledge and expertise in the fabrication of nanostructures and of their manipulation. The NanoScale proposal will produce and develop a variety of nanodevices for growing, guiding, manipulating cells, neurons and neuronal cultures. It is composed of two major ingredients: i - the combination of a MicroElectrode Arrays (MEAs) with chemical and topographic micro/nanosubstrates controlling the network growth; ii – the coupling with external measuring and/or manipulating devices such as Electron Microscopes and Optical Tweezers. We expect to provide an answer to new scientific issues and therefore achieving major scientific breakthroughs. In addition, our proposal will produce new knowledge and know-how enabling the development of new marketable products that will be commercialised by MCS.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

FP7-NMP-2007-SMALL-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
Address
Via Bonomea 265
34136 Trieste
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 353 952
Administrative Contact
Giuliana Zotta (Ms.)

Participants (7)

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 579 879
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Francesca Fortunati (Dr.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 578 828
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Niels Freese
ECOLE NORMALE SUPERIEURE
France
EU contribution
€ 579 646
Address
45, Rue D'ulm
75230 Paris Cedex 05
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yong Chen (Prof.)
NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 309 700
Address
Markwiesenstrasse 55
72770 Reutlingen
Activity type
Research Organisations
Administrative Contact
Günter Beck (Mr.)
MULTI CHANNEL SYSTEMS MCS GMBH
Germany
EU contribution
€ 316 520
Address
Aspenhaustrasse 21
72770 Reutlingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karl-Heinz Boven (Mr.)
Promoscience srl
Italy
EU contribution
€ 151 080
Address
Localita Padriciano 99
34012 Trieste
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Manuela Schipizza (Ms.)
Glance Vision Technologies s.r.l.
Italy
EU contribution
€ 160 800
Address
Via Giovanni Segantini 1/1
34100 Trieste
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Walter Vanzella (Dr.)